B. S. in chemistry, Marietta College, Marietta OH, 1975 Ph.D. in organic chemistry, University of Wisconsin, Madison, WI, 1981

Organic Synthesis and Medicinal Chemistry

Development of new tandem reaction methodology for the synthesis of cyclic compounds Synthesis of heterocyclic compounds Synthesis of new medicinal agents Study of organic reaction mechanisms

Bunce, R. A.; Herron, D. M.; Johnson, L. B.; Kotturi, S. V. "Diastereoselective synthesis of substituted tetrahydroquinoline-4-carboxylic esters by a tandem reduction-reductive amination reaction," J. Org. Chem. 2001, 66, 2822-2827.

Bunce, R. A.; Schammerhorn, J. E.; Slaughter, L. M. "Catalyst and pressure dependent reductive cyclizations for the synthesis of hexahydropyrrolo[1,2-a]quinoline-5-carboxylic esters," J. Heterocyclic Chem. 2006, 43, 1505-1511.

Bunce, R. A.; Nago, T. "1-Alkyl-2,3-dihydro-4(1H)-quinolinones by a tandem Michael-SNAr annulation reaction," J. Heterocyclic Chem. 2009, 46, 623-628.

Bunce R. A.; Squires, S. T.; Nammalwar, B. "1-Alkyl- and (±)-1,2-dialkyl-2,3-dihydro-1,8-naphthyridine-4(1H)-ones by a tandem SNAr-Michael addition reactions," J. Org. Chem. 2013, 78, 2144-2148.

Bunce, R. A.; Lee, E. J. "Ester- and ketone-substituted (±)-1-alkyl-6-nitro-1,2,3,4-tetrahydroquinolines by a tandem SNAr-Michael reaction," J. Heterocyclic Chem. 2010, 47, 1176-1182.

Bunce, R. A.; Nammalwar, B. "1,2,3,9-Tetrahydro-4H-carbazol-4-one and 8,9-di-hydropyrido[1,2-a]indol-6(7H)-one from 1H-indole-2-butanoic acid," J. Heterocyclic Chem. 2009, 46, 172-177.

Bunce, R. A.; Lee, E. J.; Grant, M. T. "Ethyl 1,4-dihydro-4-oxo-3-quinoline-carboxylates by a tandem addition-elimination-SNAr reaction," J. Heterocyclic Chem. 2011, 48, 620-625.

Bunce, R. A.; Nammalwar, B. "Ethyl 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylates by a tandem addition-elimination-SNAr reaction," J. Heterocyclic Chem., 2012, 49, 658-663.

Bunce, R. A.; Schammerhorn, J. E. "Substituted 4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate esters by a tandem imine addition-SNAr reaction" J. Heterocyclic Chem. 2013, 50, 373-380.

Bunce, R. A.; Nammalwar, B. "New conditions for synthesis of (±)-2-monosubstituted and (±)-2,2-disubstituted 2,3-dihydro-4(1H)-quinazolinones from 2-nitro- and 2-amino-benzamide," J. Heterocyclic Chem. 2011, 48, 991-997.

Nammalwar, B.; Bunce, R. A.; Benbrook, D. M.; Lu, T.; Li, H.; Chen, Y.; Berlin, K. D. "Synthesis of N-[3,4-dihydro-4-(hydroxymethyl)-2,2,4-trimethyl-2H-1-benzo-thiopyran-6-yl]-N'-(4-nitrophenyl)thiourea, a major metabolite of N-(3,4-dihydro-2,2,4,4-tetramethyl-2H-1-benzothiopyran-6-yl)-N'-(4-nitrophenyl)thiourea, Phosphorus Sulfur Silicon and the Related Elements 2011, 186, 189-204.

Nammalwar, B.; Berlin, K. D.; Bunce, R. A. "SHetA2—A mini-review of a promising anticancer drug," JSM Chem. 2013, 1, 1005.

Bourne, C. R.; Bunce, R. A.; Bourne, P. C.; Berlin, K. D.; Barrow, E. W.; Barrow, W. W. "Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity," Antimicrob. Agents Chemother. 2009, 53, 3065-3073.

Bourne, C. R.; Barrow, E. W.; Bunce, R. A.; Bourne, P. C.; Berlin, K. D.; Barrow, W. W. "Inhibition of antibiotic resistant Staphylococcus aureus by the broad‐spectrum dihydrofolate reductase inhibitor RAB1," Antimicrob. Agents Chemother. 2010, 54, 3825-3833.

Nammalwar, B.; Bunce, R. A.; Berlin, K. D.; Bourne, C. R.; Bourne, P. C.; Barrow, E.W.; Barrow,, W. W. "Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis" Eur. J. Med. Chem. 2012, 52, 387-396.

Bourne, C. R.; Wakeham, N.; Bunce, R. A.; Berlin, K. D.; Barrow, W. W. "Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets," J. Mol. Recognit. 2012, 25, 216-223.

Nammalwar, B.; Bourne, C. R.; Bunce, R. A.; Wakeham, N.; Bourne, P. C.; Ramnarayan, K.; Mylvaganam, S.; Berlin, K. D.; Barrow, E. W.; Barrow, W. W. "Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines," ChemMedChem 2012, 7, 1474-1482.

Bourne, C. R.; Wakeham, N.; Nammalwar, B.; Tseitin, V.; Bourne, P. C.; Barrow, E. W.; Ramnarayan, K.; Bunce, R. A.; Berlin, K. D., Barrow, W. W. "Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase," Biochem Biophys Acta, 2013, 1834, 46-52.