2012-2013 Northwestern University Searle Teaching Fellow 2012 Pew Scholar in Biomedical Sciences

Chemical Biology

We are a group of chemical biologists studying protein ubiquitination and protein phosphorylation signaling pathways, and misregulation of these processes in diseases.

Our highly interdisciplinary research group combines techniques of synthetic organic chemistry, biochemistry, cell biology, and protein synthesis.

Park, S.; Krist, D.T.; Statsyuk, A.V., "Protein Ubiquitination and Formation of Polyubiquitin Chains Without ATP, E1 and E2 Enzymes", Chemical Science, 2014, accepted Manuscript.

Kathman, S.; Ziyang, X.; Statsyuk, A.V., "A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases", Journal of Medicinal Chemistry, 2014, 57 (11), 4969-4974.

An, H.; Krist, D.T.; Statsyuk, A.V.,"Crosstalk between Kinases and Nedd4 family Ubiquitin Ligases", Mol. BioSyst, 2014, 10,1643-1657. 2014 Emerging Investigators Edition.

An, H.; Statsyuk, A.V.,"The Development of Activity-Based Probes for Ubiquitin and Ubiquitin-Like Protein Signaling Pathways", J. Am. Chem. Soc. 2013, 135 (45), 16948–16962.

Hong, C.M.; Statsyuk, A.V.,"The Development of a One Pot, Regiocontrolled, Three-Component Reaction for the Synthesis of Thieno[2,3-c]pyrroles", Organic & Biomolecular Chemistry, 2013, 11, 2932-2935.

Park, S.; Ntai, I.; Thomas, P.; Konishcheva, E.; Kelleher, N.; Statsuk, A.V., "Mechanism-Based Small Molecule Cross-Linkers of HECT E3 Ubiquitin Ligase - Substrate Pairs", Biochemistry-Us, 2012, 51 (42), 8327-8329.

Statsuk, A.V.; Shokat, K.M., Methods in Molecular Biology, 2012, 795, 179-190.

Statsuk, A.V.; Maly, D.J.; Seeliger, M.A.; Fabian, M.A.; Biggs, W.H. 3rd; Lockhart, D.J.; Zarrinkar, P.P.; Kuriyan, J.; Shokat, K.M., J. Am. Chem. Soc., 2008, 130, 17568-74.

Statsuk, A.V.; Bai, R.; Baryza, J.L.; Verma, V.A.; Hamel, E.; Wender, P.A.; Kozmin, S.A., Nature Chemical Biology, 2005, 7, 383-388.

Statsuk, A.V.; Liu, D.; Kozmin, S.A., J. Am. Chem. Soc. 2004, 31, 9546-9547.

Nenajdenko V.G.; Statsuk A.V.; Balenkova E.S., Chemistry of Heterocyclic Compounds, 2003, 5, 598-603.

Nenajdenko, V.G.; Statsuk, A.V.; Balenkova, E.S., Tetrahedron, 2000, 35, 6549-6556.