Education Ph.D. in Organic Chemistry. Indiana University, Bloomington, Indiana, 1999 B.S. in Chemistry. University of Notre Dame, Notre Dame, Indiana, 1994 Professional Experience Director, Northwestern Center for Molecular Innovation and Drug Discovery (CMIDD), 2010-present Northwestern University: Professor of Pharmacology, 2015-present Northwestern University: Professor of Chemistry, 2013-present Northwestern University: Associate Professor of Chemistry, 2008-2013 Northwestern University: Assistant Professor of Chemistry, 2002-2008 Research Experience Harvard University: NIH Postdoctoral Fellow with David A. Evans, 1999-2002 Indiana University/University of Michigan: Graduate Research with William R. Roush, 1994-1999 University of Notre Dame: Undergraduate Research with Marvin J. Miller, 1992-1994

Complex Synthesis Our Complex Synthesis platform is where strategic planning meets practical execution. The ability to design and conduct syntheses of architecturally complex and biologically active small molecules is invaluable for both scientific and personal advancement. Catalysis Our Catalysis platform seeks to discover, develop, and apply new catalytic methods for the efficient and selective synthesis of biomedically relevant molecules. Translational Chemistry Our dynamic Translational Chemistry platform focuses on expanding the applications of natural product-inspired compounds and using these unique scaffolds to target biologically relevant systems.

Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma Kim. D. R.; Orr, M. J.; Yu, X.; Munshi, H. H.; Wang, A.; Trudeau, C.; Kwong, A. J.; Cheng, S.-Y.; Scheidt, K. A.* ACS Med. Chem. Lett. 2024, 15, 258-264. A Platform for the Synthesis of Corynantheine-Type Corynanthe Alkaloids Nam, Y.; Tam, A. T.; Miller, E. R.; Scheidt, K. A.* J. Am. Chem. Soc. 2024, 146, 118-124. Photoinduced cerium-catalyzed C–H acylation of unactivated alkanes Cao, J,; Zhu, J. L.; Scheidt, K. A.* Chem. Sci. 2023, 15, 154-159. Cooperative Carbene Photocatalysis for β-Amino Ester Synthesis Tanaka, N.; Zhu, J. L.; Valencia, O. L.; Schull, C. R.; Scheidt, K. A.* J. Am. Chem. Soc. 2023, 145, 24486-24492. Photoredox-Catalyzed Radical–Radical Coupling of Potassium Trifluoroborates with Acyl Azoliums Rourke, M. J.; McGill, M. J.; Yang, D.; Farnam, E.J.; Zhu, J.L.; Scheidt, K. A.* Synlett. 2023, 34, 2175-2180. Light-Driven Enantioselective Carbene-Catalyzed Radical-Radical Coupling Byun, S.; Hwang, M.; Wise, H.; Bay, A.; Cheong, P.; Scheidt, K. A.* Angew. Chem. Int. Ed. 2023, 62, e2023128. Photocatalyzed Direct α-Alkylation of Esters Using Styrenes Wang, P.; Bay, A. V.; Farnam, E. J.; Scheidt, K. A.* Adv. Synth. Catal. 2023, 365, 2361-2366. Visible light-induced coupling of carboxylic acids with alcohols/amines via a phosphorous linchpin strategy Peng, Q.; Gogoi, A. R.; Renteria-Gomez, A.; Gutierrez, O.; Scheidt, K. A.* Chem 2023, 9, 1983-1993. Acyl Azolium–Photoredox-Enabled Synthesis of β-Keto Sulfides Rourke, M.J.; Wang, C.T.; Schull, C.R.; Scheidt, K. A.* ACS Catal. 2023, 13, 7987-7994. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors Kim, D. R; Orr, M. J.; Kwong, A. J.; Deibler, K. K.; Munshi, H. H.; Bridges, C. S; Chen, T. J.; Zhang, X.; Lacorazza, H. D.; Scheidt, K. A.* ACS Med. Chem. Lett. 2023, 14, 606-613. Photoinduced Acylations Via Azolium-Promoted Intermolecular Hydrogen Atom Transfer Zhu, J. L.; Schull, C. R.; Tam, A. T.; Renteria-Gomez, A.; Gogoi, A. R.; Gutierrez, O.; Scheidt, K. A.* J. Am. Chem. Soc. 2023, 145, 1535-1541. Enantioselective Copper-Catalyzed Borylative Amidation of Allenes Byun, S.; Farah, A.O.; Wise, H.R.; Katchmar, A.; Cheong, P.H.-Y; Scheidt, K.A* J. Am. Chem. Soc. 2022, 144, 22850-22857. Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization Liu, Y.; Betori, R. C.; Pagacz, J.; Frost, G. B.; Efimova, E. V.; Wu, D.; Wolfgeher, D. J.; Bryan, T. M.; Cohen, S. B.; Scheidt, K. A.; Kron, S. J.* Cell Chem. Biol. 2022, 29, 1517-1531. Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain McCollum, M. M.; Larmore, M.; Ishihara, S.; Ng, L. C. T.; Kimura, L. F.; Guadarrama, E.; Ta, M. C.; Vien, T. N.; Frost, G. B.; Scheidt, K. A.; Miller, R. E.; DeCaen, P. G.* Cell Rep. 2022, 40, 111248. Synthesis of Cyclohexanones by a Tandem Photocatalyzed Annulation Bay, A. V.; Farnam, E. J.; Scheidt, K. A.* J. Am. Chem. Soc. 2022, 144, 7030-7037. Discovery of Highly Potent Serotonin 5-HT2 Receptor Agonists Inspired by Heteroyohimbine Natural Products Orr, M. J.; Cao, A. B.; Wang, C. T.; Gaisin, A.; Csakai, A.; Friswold, A. P.; Meltzer, H. Y.; McCorvy, J. D.*; Scheidt, K. A.* ACS Med. Chem. Lett. 2022, 13, 648-657. Single-electron carbene catalysis in redox processes Bay, A. V.; Scheidt, K. A.* Trends Chem. 2022, 4, 277-290. Enantioselective Syntheses of Yohimbine Alkaloids: Proving Grounds for New Catalytic Transformations Scheidt, K. A.*; Miller, E. R. Synthesis. 2021, 54, 1217-1230. Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma Kwong, A. J.; Pham, T. N. D.; Oelschlager, H. E.; Munshi, H. G.*; Scheidt, K. A.* ACS Med. Chem. Lett. 2021, 12, 1559-1567. Combined Photoredox and Carbene Catalysis for the Synthesis of γ-Aryloxy Ketones Wang, P.; Fitzpatrick, K. P.; Scheidt, K. A.* Adv. Synth. Catal. 2021, 364, 518-524. Light-Driven Carbene Catalysis for the Synthesis of Aliphatic and α-Amino Ketones Bay, A. V.; Fitzpatrick, K. P.; González-Montiel, G. A.; Farah, A. O.; Cheong, P. H.-Y.*; Scheidt, K. A.* Angew. Chem. Int. Ed. 2021, 60, 17925-17931. Photocatalytic acyl azolium-promoted alkoxycarbonylation of trifluoroborates Zhu, J. L.; Scheidt, K. A.* Tetrahedron 2021, 92, 132288. Computational planning of the synthesis of complex natural products Mikulak-Klucznik, B.; Gołębiowska, P.; Bayly, A. A.; Popik, O.; Klucznik, T.; Szymkuć, S.; Gajewska, E. P.; Dittwald, P.; Staszewska-Krajewska, O.; Beker, W.; Badowski, T.; Scheidt, K. A.; Molga, K.*; Młynarski, J.*; Mrksich, M.*; Grzybowski, B. A.* Mechanism and Origins of Selectivity in the Enantioselective oxa-Pictet-Spengler Reaction: A Cooperative Catalytic Complex from a Hydrogen Bond Donor and Chiral Phosphoric Acid Maskeri, M. A.‡; Brueckner, A. C.‡; Feoktistova, T.; O’Connor, M. J.; Walden, D. M.; Cheong P. H.-Y.*; Scheidt, K. A.*Chem. Sci. 2020, 11, 8736-8743. High-throughput photocapture approach for reaction discovery Bayly, A. A.; McDonald, B. R.; Mrksich, M.*; Scheidt, K. A.*Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 13261-13266. Development of Ferrocene-Based Planar Chiral Imidazopyridinium Salts for Catalysis Fitzpatrick, K. P.; Schwamb, C. B.; Check, C. T.; Jang, K.-P.; Barsoum, D. N.; Scheidt, K. A.*Organometallics 2020, 39, 2705-2712. Radical coupling of β-keto esters and amides promoted by Brønsted/Lewis acids Zhu, J. L.; Laws, S. M.; Rourke, M. J.; Scheidt, K. A.* Green Synth. Catal. 2020, 1, 70-74. Non-classical MEKs: A review of MEK3-7 inhibitors Kwong, A. J.; Scheidt, K. A.*Bioorg. Med. Chem. Lett. 2020, 30, 127203. Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids Bay, A. V.‡; Fitzpatrick, K. P.‡; Betori, R. C.; Scheidt, K. A.*Angew. Chem. Int. Ed. 2020, 59, 9143-9148. A Sequential Umpolung/Enzymatic Dynamic Kinetic Resolution Strategy for the Synthesis of γ-Lactones Maskeri, M. A.; Schrader, M. L.; Scheidt, K. A.*Chem. Eur. J. 2020, 26, 5794-5798. Targeted Covalent Inhibition of Telomerase Betori, R. C.; Liu, Y.; Mishra, R. K.; Cohen, S. B.; Kron, S. J.; Scheidt, K. A.*ACS Chem. Biol. 2020, 15, 706-717. A Concise, Enantioselective Approach for the Synthesis of Yohimbine Alkaloids Miller, E. R.; Hovey, M. T.; Scheidt, K. A.*J. Am. Chem. Soc. 2020, 142, 2187-2192.