Structural Biology, Biochemistry, and Biophysics

The SMC1-SMC3 cohesin heterodimer structures DNA through supercoiling-dependent loop formation. Sun M, Nishino T, and Marko JF. Nucleic Acids Research. 2013 July 8;41(12):6149-6160. ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor, Laboratory of Genetics and Physiology 2 (LGP2). Bruns AM, Pollpeter D, Hadizadeh N, Myong S, Marko JF, and Horvath CM. Journal of Biological Chemistry. 2013 January 11;288(2):938-946. Histone H1 compacts DNA under force and during chromatin assembly. Xiao B, Freedman BS, Miller KE, Heald R, and Marko JF. Molecular Biology of the Cell. 2012 December 15;23(24):4864-4871. Range of Interaction between DNA-Bending Proteins is Controlled by the Second-Longest Correlation Length for Bending Fluctuations. Zhang H and Marko JF. Physical Review Letters. 2012 December 14;109(24):248301. Self-organization of domain structures by DNA-loop-extruding enzymes. Alipour E and Marko JF. Nucleic Acids Research. 2012 December;40(22):11202-11212.