Ph.D. Chemical Engineering, University of California, Berkeley, CA Management of Technology Certificate, Haas School of Business, University of California, Berkeley, CA B.S. Chemical Engineering, Stanford University, Palo Alto, CA

Synthetic biology, gene therapy, computational and experimental systems biology

Ragan A. Pitner, Andrew H. Scarpelli, Joshua N. Leonard, “Regulation of Bacterial Gene Expression by Protease-Alleviated Spatial Sequestration (PASS)”, ACS Synthetic Biology, (2015) Leonard, Joshua N.; Gy?_rgy, Bence; Hung, Michelle E.; Breakefield, Xandra O., “Therapeutic applications of extracellular vesicles: Clinical promise and open questions”, Annual Review of Pharmacology and Toxicology, (2015) Daringer, Nichole M.; Leonard, Joshua N.; Schwarz, Kelly A., “Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4”, Journal of Biological Chemistry, (2015) Leonard, Joshua N.; Hung, Michelle E., “Stabilization of exosome-targeting peptides via engineered glycosylation”, Journal of Biological Chemistry, (2015) Leonard, Joshua N.; Kath, William L.; Wells, Daniel K.; Chuang, Yishan; Knapp, Louis M., “Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks”, PLoS Computational Biology, (2015) Daringer, Nichole M.; Leonard, Joshua N.; Schwarz, Kelly A.; Dudek, Rachel M., “Modular Extracellular sensor architecture for engineering mammalian cell-based devices”, ACS Synthetic Biology, (2014) Leonard, Joshua N., “The Rise of Mammals”, ACS Synthetic Biology, (2014) Leonard, Joshua N.; Chuang, Yishan; Dudek, Rachel M., “Engineered cell-based therapies: A vanguard of design-driven medicine”, Advances in Experimental Medicine and Biology, (2014) Gower, R. Michael; Boehler, Ryan M.; Azarin, Samira M.; Ricci, Christine F.; Leonard, Joshua N., “Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression”, Biomaterials, (2014) Ivett Jelinek;Joshua N. Leonard;Graeme E. Price;Kevin N. Brown;Anna Meyer-Manlapat;Paul K. Goldsmith;Yan Wang;David Venzon;Suzanne L. Epstein;David M. Segal, “TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection”, Journal of Immunology, (2011) S Samuel-Abraham;JN Leonard, “Staying on message: design principles for controlling nonspecific responses to siRNA”, Febs Journal, (2010) Brian R Fritz;Laura E Timmerman;Nichole M Daringer;Joshua N Leonard;Michael C Jewett, “Biology by design: from top to bottom and back”, J Biomed Biotechnol, (2010) JN Leonard, PS Shah, JC Burnett, DV ..., “HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory Mechanism”, Cell Host & Microbe, (2008) JN Leonard, R Ghirlando, J Askins, JK Bell, ..., “The TLR3 signaling complex forms by cooperative receptor dimerization”, Proceedings of the National Academy of Sciences, (2008) JN LEONARD, R GHIRLANDO, J ASKINS, et al., “The TLR3 signaling complex forms by cooperative receptor dimerization”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (2008) L LIU, I BOTOS, Y WANG, et al., “Structural basis of toll-like receptor 3 signaling with double-stranded RNA”, SCIENCE, (2008)