Bronowska, Agnieszka 照片

Bronowska, Agnieszka

Dr

所属大学: Newcastle University

所属学院: School of Chemistry

邮箱:
agnieszka.bronowska@ncl.ac.uk

个人主页:
http://www.ncl.ac.uk/chemistry/staff/profile/agnieszkabronowska.html#background

个人简介

1994-1998 - M.Sc. in theoretical chemistry, University of Warsaw, Poland 1998-2001 - Ph.D. in computational medicinal chemistry, University of Warsaw, Poland

近期论文

Peralta D, Bronowska AK, Morgan B, Dóka é, VanLaer K, Nagy P, Gr?ter F, Dick TP. A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nature Chemical Biology 2015, 11, 156-163. Zhou J, Bronowska AK, LeCoq J, Lietha D, Gr?ter F. Allosteric regulation of focal adhesion kinase by PIP? and ATP. Biophysical Journal 2015, 108(3), 698-705. Aponte-Santamaría C, Huck V, Posch S, Bronowska AK, Gr?ssle S, Brehm MA, Obser T, Schneppenheim R, Hinterdorfer P, Schneider SW, Baldauf C, Gr?ter F. Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions. Biophysical Journal 2015, 108(9), 2312-2321. Zhou J, Aponte-Santamaria C, Sturm S, Bullerjahn JT, Bronowska A, Graeter F. Mechanism of Focal Adhesion Kinase Mechanosensing. PLoS Computational Biology 2015, 11(11), e1004593. White SJ, Johnson SD, Sellick MA, Bronowska AK, Stockley PG, W?lti C. The influence of two-dimensional organization on peptide conformation. Angewandte Chemie International Edition 2015, 54(3), 974-978. Go?i GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska AK, Martín MT, Eck MJ, Kremer L, Gr?ter F, Gervasio FL, Perez-Moreno M, Lietha D. Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proceedings of the National Academy of Sciences of the United States of America 2014, 111(31), E3177-E3186. Kolár M, Hobza P, Bronowska AK. Plugging the explicit σ-holes in molecular docking. Chem Commun (Camb) 2013, 49(10), 981-983. Brahmkshatriya PS, Dobes P, Fanfrlik J, Rezá? J, Paruch K, Bronowska AK, Lepsík M, Hobza P. Quantum mechanical scoring: structural and energetic insights into cyclin-dependent kinase 2 inhibition by pyrazolo[1,5-a]pyrimidines. Curr Comput Aided Drug Des 2013, 1, 118-129. White SJ, Morton DW, Cheah BC, Bronowska AK, Davies AG, Stockley PG, W?lti C, Johnson S. On-surface assembly of coiled-coil heterodimers. Langmuir 2012, 28(39), 13877-82. Johnson S, Bronowska AK, Chan J, Evans D, Davies AG, W?lti C. Redox-induced conformational change in mercaptoalkanoic acid multilayer films. Langmuir 2012, 28(16), 6632-7. Xia F, Bronowska AK, Cheng S, Gr?ter F. Base-catalyzed peptide hydrolysis is insensitive to mechanical stress. J Phys Chem B 2011, 115(33), 10126-32. Bronowska AK. Thermodynamics of Ligand-Protein Interactions: Implications for Molecular Design. In: Juan Carlos Moreno-Pirajan, ed. "Thermodynamics - Interaction Studies - Solids, Liquids and Gases". InTech, 2011. Evans DA, Bronowska AK. Implications of fast-time scale dynamics of human DNA/RNA cytosine methyltransferases (DNMTs) for protein function. Theoretical Chemistry Accounts 2010, 125(3), 407-418. Fanfrlík J, Bronowska AK, Rezác J, Prenosil O, Konvalinka J, Hobza P. A Reliable Docking/Scoring Scheme Based on the Semiempirical Quantum Mechanical PM6-DH2 Method Accurately Covering Dispersion and H-Bonding: HIV-1 Protease with 22 Ligands. J Phys Chem B 2010, 114(39), 12666-78. Syme NR, Dennis C, Bronowska A, Paesen GC, Homans SW. Comparison of Entropic Contributions to Binding in a "Hydrophilic" versus "Hydrophobic" Ligand-Protein Interaction. Journal of the American Chemical Society 2010, 132(25), 8682-8689. Merino A, Bronowska AK, Jackson DB, Cahill DJ. Drug profiling: knowing where it hits. Drug Discov Today 2010, 17(18), 749-56. St?ckmann H, Bronowska A, Syme NR, Thompson GS, Kalverda AP, Warriner SL, Homans SW. Residual Ligand Entropy in the Binding of p-Substituted Benzenesulfonamide Ligands to Bovine Carbonic Anhydrase II. Journal of the American Chemical Society 2008, 130(37), 12420-12426. MacRaild CA, Daranas AH, Bronowska A, Homans SW. Global changes in local protein dynamics reduce the entropic cost of carbohydrate binding in the arabinose-binding protein. Journal of Molecular Biology 2007, 368(3), 822-832. Shimokhina N, Bronowska A, Homans SW. Contribution of ligand desolvation to binding thermodynamics in a ligand-protein interaction. Angewandte Chemie: International Edition 2006, 45(38), 6374-6376. Barratt E, Bronowska A, Vondrásek J, Cerny J, Bingham R, Phillips S, Homans SW. Thermodynamic penalty arising from burial of a ligand polar group within a hydrophobic pocket of a protein receptor. Journal of Molecular Biology 2006, 362(5), 994-1003.