B.S. Fordham University, Bronx, NY 2003 Ph.D. Johns Hopkins University, Baltimore, MD 2008 Postdoctoral, University of Pennsylvania 2010

Organic Chemistry

My research program will focus on the exploration of new chemical space with interests at the interface between chemistry and biology. Through diversity-oriented synthesis, one of our goals is to engineer potential chemotherapeutics and small-molecule inhibitors, with a focus on designing compound libraries inspired by nature. My main research interest entails the development of new synthetic methods with application to short, efficient natural and natural product-like total syntheses. Secondary metabolites, of marine origin, which possess interesting molecular architecture as well as promising biological activity will be our primary targets.

Mehrotra, S.; Duggan, B. M.; Tello-Aburto, R.; Newar, T. D.; Gerwick, W. H.; Murray, T. F.; Maio, W. A. “Detailed Analysis of (−)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists.” J. Nat. Prod. ASAP DOI: 10.1021/np500644k

deGruyter, J. N.; Maio, W. A. “The Taumycin A Macrocycle: Asymmetric Total Synthesis and Revision of Relative Stereochemistry.” Org. Lett. 2014, 16, 5196-5199.

Tello-Aburto, R.; Newar, T.D.; Maio, W.A. “Evolution of a Protecting Group Free Total Synthesis: Studies En Route to the Neuroactive Marine Macrolide (–)-Palmyrolide A.” J. Org. Chem. 2012, 77, 6271.

Tello-Aburto, R.; Johnson, E.M.; Valdez, C.K.; Maio, W.A. “Asymmetric Total Synthesis and Absolute Stereochemistry of the Neuroactive Marine Macrolide Palmyrolide A.” Org. Lett. 2012, 14, 2150. Featured in Synfacts: Ley, S. V.; Browne, D. L. Synfacts 2012, 8, 708.

William Anthony Maio “Inventing New Synthetic Ring Enlargement Methods and Exploring the Use of Novel Trioxanes for the Treatment of Malaria.” The Johns Hopkins University, 2009, 176 pp., Advisor: Gary H. Posner

Posner, G.H.; Maio, W.A.; Kalinda, A.S. “Electronically Stabilized Versions of the Antimalarial Acetal Trioxanes Artemether and Artesunate.” Biorg. Med. Chem. 2008, 16, 5247.

Posner, G.H.; Chang, W.; Hess, L.; Woodard, L.; Sinishtaj, S.; Usera, A.; Maio, W.A.; Rosenthal, A.S.; Kalinda, A.S.; D’Angelo, J.G.; Petersen, K.; Stohler, R.; Chollet, J.; Santo-Thomas, J.; Snyder, C.; Rottman, M.; Wittlin, S.; Brun, R.; Shapiro, T. “Malaria-infected Mice are cured by Oral Administration of New Artemisinin Derivatives.”J. Med. Chem. 2008, 51, 1035.

Maio, W.A.; Posner, G.H. “Cyclopentanone Ring Expansion Leading to Functionalized delta-Lactams: Short Synthesis of Simple Sedum Alkaloids.” Org. Lett. 2007, 9, 2673.

Posner, G.H.; Hatcher, M.A.; Maio, W.A. “New Silicon-Mediated, Sequential Ring Expansions of n-sized 2-Cycloalkenones into Hydroxyolefinic n+m+p Medium-Sized Lactones: Short Synthesis of (-)-Phoracantholide-J.” Org. Lett. 2005, 7, 4301.

Ciaccio, J.A.; Smrtka, M.; Maio, W.A.; Rucando, D. “Synthesis of b-Hydroxy Nitriles and 1,3-Amino Alcohols from Epoxides Using Acetone Cyanohydrin as a LiCN Precursor.” Tetrahedron Lett. 2004, 45, 7201.