B.S., M.S., Madras 1973, 1975 Ph.D., Ohio State 1980 Postdoctoral, Stanford 1980 Postdoctoral, Wisconsin 1982

Organic Chemistry

Chelators for Environmental Applications Remediation of transuranic waste (Plutonium processing) Water soluble chelators for soil washing and decontamination Selective extractants for actinides-Calixarenes Polymeric chelators for radioactive waste stream remediation using ultrafiltration Selective separation of cesium and strontium from spent nuclear fuel rods Chelators for use in supercritical carbon dioxide (Argonne National Lab collaboration) ASGwebChelators

Chelators for Biomedical Applications Develop chelators for in-vivo removal of excess Fe3+ for treatment of Cooley’s anemia (therapeutic applications) Understand the mechanism for siderophore mediated transport of Fe3+ across the cell membrane in bacteria and other systems Development of diagnostic agents such as contrast agents for magnetic resonance imaging ASGwebBiomedChelators

Ligand Development Develop convenient methodology for the preparation of useful metal ion binding systems Develop practical tethering technology for attachment of ligands to useful platforms Develop new ligand systems for metal ion binding ASGwebLigands

Synthetic Methodology-Sulfones Methods to prepare chiral amino and hydroxysulfones Investigation of novel cyclization chemistry to prepare heterocycles • Applications to the synthesis of biologically interesting targets

3,2-Hydroxypyridinone (3,2-HOPO) Vinyl Sulfonamide and Acrylamide Linkers: Aza-Michael Addition Reactions and Preparation of Poly-HOPO Chelators Martinez, G.; Arumugam, J.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron Lett. (in press).

Preparation of Bifunctional Isocyanate Hydroxamate Linkers: Synthesis of Carbamate and Urea Tethered Polyhydroxamic Acid Chelators Fernando, R.; Shirley, J. M.; Torres, E.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron Lett. 2012, 53, 6367-6371.

Synthetic Approaches to Mixed Ligand Chelators on T-Butylphenol-Formaldehyde Oligomer (PFO) Platforms Young, J. A.; Karmakar, S.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron, 2012, 68, 10030-10039.

A New Approach to Fused Furan Ring Systems and Benzofurans: Intramolecular Cyclization Reactions of Unsaturated Acyloxy Sulfone Derivatives Liu, Y.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron Lett,. 2011, 52, 2935-2939.

A New Approach to Cyclic Hydroxamic Acids: Intramolecular Cyclization of N-Benzyloxy Carbamates with Carbon Nucleophiles Liu, Y.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron, 2011, 67, 2206-2214. PMCID: 3076681.

Chiral Oxazolidinones as Electrophiles: Intramolecular Cyclization Reactions with Carbanions and Preparation of Functionalized Lactams Gibson, S.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron Lett., 2011 52, 887-890. PMCID: 3084007.

New Synthetic Approach for the Incorporation of 3,2-Hydroxypyridinone (HOPO) Ligands: Synthesis of Structurally Diverse Poly HOPO Chelators Arumugam, J.; Brown, H. A.; Jacobs, H. K.; Gopalan, A. S. Synthesis, 2011, 57-64.

Concurrent Esterification and N-Acetylation of Amino Acids with Orthoesters: A Useful Reaction with interesting Mechanistic Implications Gibson, S.; Romero, D.; Jacobs, H. K.; Gopalan, A. S. Tetrahedron Lett., 2010, 51, 6737-6740. PMCID: 3030124.

Synthesis and Iron Sequestration Equilibria of Novel Exocyclic 3-Hydroxy-2-Pyridinone Donor Group Siderophore Mimics Harrington, J. M.; Chittamuru, S.; Dhungana, S.; Jacobs, H. K.; Gopalan, A. S.; Crumbliss, A. L. Inorganic Chemistry, 2010, 49, 8208-8221.

Reactions of N-Benzyloxycarbamate Derivatives with Stabilized Carbon Nucleophiles-A New Synthetic Approach to Polyhydroxamic Acids and Other Hydroxamate Containing Mixed Ligand Systems Liu, Y.; Jacobs, H. K.; Gopalan, A. S. Journal of Organic Chemistry, 2009, 74, 782-788.

Synthetic Methodology for the Preparation of N-hydroxysulfamides Devanathan, K.; Bell, J.A.; Wilkins, P.C.; Jacobs, H.K.; Gopalan, A.S. Tetrahedron Lett., 2007, 48, 8029-8033

New Methodology for the Preparation of 3-hydroxy-2-pyridinone (3,2-HOPO) Chelators 2. Reactions of Alcohols, Phenols and Thiols with a Novel Electrophilic 3,2-HOPO Precursor Chittamuru, S.; Lambert, T.N.; Martinez, G.; Jacobs, H.K.; Gopalan, A.S. Tetrahedron Lett., 2007, 48, 567-571

Selective Fluorescence Detection of Divlant and Trivalent Metal Ions with Functionalized Lipid Membranes Pincus, J.L.; Jin, C.; Huang, W.; Jacobs, H.K.; Gopalan, A.S.; Song, Y.; Shelnutt, J.A.; Sasaki, D.Y. J. Mater. Chem., 2005, 15, 2938-45

Mechanistic variations in the oxidation of Piloty’s acid by metal complexes Wilkins, P. C.; Jacobs, H. K.; Johnson, M. D.; Gopalan, A. S. Inorganic Chemistry, 2004, 43, 7877-7881

Synthesis of ether-linked fluorocarbon surfactants and their aggregational properties in organic solvents Huang, W.; Jin, C.; Derzon, D. K.; Huber, T. A.; Last, J. A.; Provencio, P. P.; Gopalan, A. S.; Dugger, M.; Sasaki, D. Y. Journal of Colloids and Interface Science, 2004, 272, 457-464.

Synthesis of symmetrical methylenebis(alkyl hydrogen phosphonates) by selective cleavage of methylenebis(dialkyl phosphonates) with morpholine Gantla, V. R.; Jacobs, H.; Gopalan, A. S.; Barrans Jr., R. E.; Dietz, M. L.; Stepinski, D.; Herlinger, A. W. Synthetic Communications, 2004, 34(2), 331-344.

Supercritical Carbon Dioxide-Separations and Processes Gopalan, A.S.; Wai, C. M.; Jacobs, H.K., Eds. ACS Symposium Series (Volume 860), American Chemical Society, Washington, DC; 2003.

“An Introduction to Separations and Processes Using Supercritical Carbon Dioxide” in Supercritical Carbon Dioxide-Separations and Processes” Gopalan, A.S.; Wai, C. M.; Jacobs, H.K., Eds. ACS Symposium Series (Volume 860), American Chemical Society, Washington, DC; 2003, pp. 2–8.

Synthesis of lactams and other nitrogen heterocycles by intramolecular cyclizations of carbamates and acyl derivatives of aminosulfones Hernandez, N.M.; Sedano, M.J.; Jacobs, H.K.; Gopalan*, A.S. Tetrahedron Letters, 2003, 44, 4035-4039.

Synthesis and metal ion complexation properties of a novel polyethyleneimine N-methylhydroxamic acid water soluble polymer Bisset, W.; Jacobs, H.K.; Koshti, N.; Stark, P.; Gopalan*, A.S. Reactive and Functional Polymers, 2003, 55, 109-119.