The up and downside of white blood cells

Professor Michael Hickey says leukocytes, or white blood cells, are both the good and bad guys of our immune system. While these cells are critical to our ability to recognise and fight infections, they are also responsible for some of our most debilitating inflammatory diseases, including rheumatoid arthritis, asthma and multiple sclerosis. Michael is researching how leukocytes enter inflamed tissues, which could lead to a better understanding of inflammatory diseases.

Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus Finsterbusch, M., Hall, P. H., Li, A., Devi, S., Westhorpe, C. L., Kitching, A. R. & Hickey, M. J. 30 Aug 2016 In : Proceedings of the National Academy of Sciences. 113, 35, p. 172 - 181 9 p., E5 Research - peer-review › Article Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury Snelgrove, S. L. L., Lo, C., Hall, P., Lo, C. Y. Y., Alikhan, M. A. A., Coates, T. T., Holdsworth, S. R. R., Hickey, M. J. J. & Kitching, R. R. 5 Aug 2016 In : Transplantation. p. 1 - 40 40 p. Research - peer-review › Article Endogenous toll-like receptor 9 regulates AKI by promoting regulatory T cell recruitment Alikhan, M., Summers, S. A., Gan, P. Y., Chan, A., Khouri, M., Ooi, J., Ghali, J., Odobasic, D., Hickey, M. J., Kitching, A. R. & Holdsworth, S. R. 2016 In : Journal of the American Society of Nephrology. 27, 3, p. 706 - 714 9 p. Research - peer-review › Article CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages Engel, D. R., Krause, T. A., Snelgrove, S. L., Thiebes, S., Hickey, M. J., Boor, P., Kitching, A. R. & Kurts, C. 2015 In : Journal of Immunology. 194, 4, p. 1628 - 1638 11 p. Research - peer-review › Article Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing Chow, Z., Banerjee, A. & Hickey, M. J. 2015 In : Immunology and Cell Biology. 93, 4, p. 355 - 363 9 p. Research - peer-review › Article Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression King, P. T. , O'Sullivan, K. , Selemidis, S. , Lo, C. Y-W. , Farmer, M. , Ngui, J. , Broughton, B. R. S. , Thomas, B. , Hickey, M. J. , Holmes, P. , Bardin, P. G. , Holdsworth, S. R. & 10 others 2015 In : PLoS ONE. 10, 3 (Art. No.: e0120371), p. 1 - 17 17 p. Research - peer-review › Article