Our broadly-based research interests are in developmental neurobiology, neural regeneration, and demyelinating disorders of the nervous system. Our current investigative endeavours are focused on: 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a protein that appears early in CNS development, a determinant of oligodendrocyte differentiation and maturation that entrains early stages of myelinogenesis; we seek to understand how CNP participates in these complex events, and how one might capitalize on this knowledge to enhance therapeutic remyelination in diseased CNS. Molecules associated with myelin that provide a non-permissive environment for nerve re-growth in the injured CNS; therapeutic strategies to overcome these inhibitors. We employ a combination of biochemistry, cellular neurobiology and recombinant DNA technologies to address these interests. Our recently generated transgenic mouse models facilitate these endeavours