Chemical Biology and Natural Product Chemistry, in particular Marine Natural Products and chemical proteomics. Phage display/yeast surface display in the isolation of small molecule bining proteins (Reverse Chemical Proteomics). Structure and dynamics of biomolecules using high-field NMR spectroscopy.

Peixoto, P. A., Boulange, A., Ball, M., Naudin, B., Alle, T., Cosette, P., Karuso, P. Franck, X. (2014) "Design and Synthesis of Epicocconone Analogues with Improved Fluorescence Properties" J. Am. Chem. Soc., 136, 15248-56 Shengule, S. R., Karuso, Peter "Diastereoselective Pictet-Spengler reactions of a tethered 2-aminoimidazole" (2014) Aust. J. Chem., 67, 184-91. Chatterjee, S., Karuso, P., Boulange, A., Peixoto, P. A., Franck, X., Datta, A. "The Role of Different Structural Motifs in the Ultrafast Dynamics of Second Generation Protein Stains" J. Phys. Chem. B (2013), 117, 14951-9. Shengule, S. R., Karuso, Peter "Three-component Mannich-like reaction of 2-aminoimidazole" Aust. J. Chem. (2011), 64, 1617-20. Shengule, S. R., Loa-Kum-Cheung, W. L., Parish, C. R., Blairvacq, M., Meijer, L., Nakao, Y., Karuso, Peter "A One-Pot Synthesis and Biological Activity of Ageladine A and Analogues" J. Med. Chem. (2011), 54, 2492-503. Bickmeyer, U., Heine, M., Podbielski, I., Muend, D., Köck, M., Karuso, Peter "Tracking of fast moving neuronal vesicles with ageladine A" Biochem. Biophys. Res. Commun. (2010), 402, 489-94. Piggott, A. M., Kriegel, A. M., Willows, R. D., Karuso, Peter "Rapid isolation of novel FK506 binding proteins from multiple organisms using gDNA and cDNA T7 phage display" Bioorg. Med. Chem. (2009), 17, 6841-50. Piggott, A. M. and Karuso, P. (2008) "Rapid identification of a protein binding partner for the marine natural product kahalalide F using reverse chemical proteomics" ChemBioChem, 9, 524-30. Karuso, P., Crawford, A. S., Veal, D. A., Scott, G. B. I. and Choi, Y-H. (2008) "Real-time fluorescence monitoring of proteolysis" J. Proteome Res., 7, 361-6. Ball, M. S. and Karuso, Peter "Mass Spectral Compatibility of Four Proteomics Stains" J. Proteome Res. (2007), 6, 4313-20