The Jaschke lab is currently working to answer three fundamental questions in the field of genome engineering using the model bacteriophage øX174:

(1) What are the essential minimal components of the øX174 genome?

(2) In what ways can we reconfigure the essential øX174 genome components while still maintaining a viable virus?

(3) How can we use evolution to tune our rational øX174 genome designs?

Ariel Hecht*, Jeff Glasgow*, Paul R. Jaschke*, Lukmaan Bawazer*, Matthew S. Munson, Jennifer Cochran, Drew Endy, Marc Salit. (2016). Measurements of translation initiation from all 64 codons in E. coli. Nucleic Acids Research. Under Review. Maxwell Bates, *Aaron Berliner, Joe Lachoff, Paul R. Jaschke, Eli Groban. (2016). Wet Lab Accelerator: A Web-Based Application Democratizing Laboratory Automation for Synthetic Biology. ACS Synthetic Biology. ​Ariel Hecht*, Jeff Glasgow*, Paul R. Jaschke*, Lukmaan Bawazer*, Matthew S. Munson, Jennifer Cochran, Drew Endy, Marc Salit. (2016). Measurements of translation initiation from all 64 codons in E. coli. bioRxiv. Pre-print. Hessel A, Quinn J, Jaschke PR. Sequence of Synthetic øX174 Bacteriophage. Museum of Modern Art (MoMA). Accessioned Item. New York, USA (Invited Exhibit) Hessel A, Quinn J, Jaschke PR. Synthetic øX174 Bacteriophage. Design and Violence Exhibit. Museum of Modern Art (MoMA). New York, USA (Invited Exhibit).