Studied chemistry at Darmstadt and Salt Lake City/USA 1991 PhD, Basel/Switzerland 1992-1993 Postdoctoral research, Los Angeles/USA 1997 Habilitation, TU Berlin 1998 Privatdozent, TU Berlin Since 1998 Professor of Organic Chemistry (C3), LMU Münc

Nucleophilic organocatalysis Mechanistic aspects of acyl-transfer reactions Theoretical studies of radicals in enzymatic catalysis

P. Quinio, C. Francois, A. Escribano Cuesta, A. K. Steib, F. Achrainer, H. Zipse, K. Karaghiosoff, P. Knochel, "Preparation of Tri- and Tetrasubstituted Allenes via Regioselective Lateral Metalation of Benzylic (Trimethylsilyl)alkynes Using TMPZnCl·LiCl" Org. Lett. 2015, 17, 1010-1013. [DOI: 10.1021/acs.orglett.5b00114] K. Moriya, D. Didier, M. Simon, J. M. Hammann, G. Berionni, K. Karaghiosoff, H. Zipse, H. Mayr, P. Knochel, "Stereoselektive Synthesis and Reactions of 3-Functionalized Secondary Alkyllithiums" Angew. Chem. Int. Ed. 2015, 54, 2754 - 2757. [DOI: 10.1002/anie.201409165] J. Hioe, D. Sakic, V. Vrcek, H. Zipse, "The Stability of Nitrogen-Centered Radicals" Org. Biomol. Chem. 2015, 13, 157 - 169. [DOI: 10.1039/C4OB01656D] F. Achrainer, H. Zipse, "Transfer Hydrogenation in Open-Shell Nucleotides — A Theoretical Survey" Molecules 2014, 19, 21489 — 21505. [DOI: 10.3390/molecules191221489] X. Guo, H. Zipse, H. Mayr "Mechanisms of Hydride Abstractions by Quinones" J. Am. Chem. Soc. 2014, 136, 13863 - 13873. [DOI: 10.1021/ja507598y] F. Achrainer, V. N. Emel’yanenko, W. Tantawy, S. P. Verevkin, H. Zipse, "Transfer Hydrogenation as a Redox Process in Nucleotides" J. Phys. Chem. B 2014, 118, 10426 – 10429. [ DOI: 10.1021/jp507855k] P. Patschinski, C. Zhang, H. Zipse, "The Lewis Base-Catalyzed Silylation of Alcohols — A Mechanistic Analysis" J. Org. Chem. 2014, 79, 8348 – 8357. [DOI: 10.1021/jo5016568] C. Zhang, P. Patschinski, D. S. Stephenson, R. Panisch, J. H. Wender, M. C. Holthausen, H. Zipse, "The Calculation of 29Si NMR Chemical Shifts of Tetracoordinated Silicon Compounds in the Gas Phase and in Solution" Phys. Chem. Chem. Phys. 2014, 16, 16642 - 16650. [DOI: 10.1039/C4CP01736F] A. Frischmuth, M. Fernandez, N. M. Barl, F. Achrainer, H. Zipse, G. Berionni, H. Mayr, K. Karaghiosoff, P. Knochel, "New In Situ Trapping Metalations of Functionalized Arenes and Heteroarenes with TMPLi in the Presence of ZnCl2 and Other Metal Salts" Angew. Chem. Int. Ed. 2014, 53, 7928 - 7932. [DOI: 10.1002/anie.201403688] P. Hommes, C. Fischer, C. Lindner, H. Zipse, H.-U. Reissig, "Unprecedented Strong Lewis Bases — Synthesis and Methyl Cation Affinities of Dimethylamino-Substituted Terpyridines" Angew. Chem. Int. Ed. 2014, 53, 7647 - 7651. [DOI: 10.1002/anie.201403403] F. Achrainer, F. Barth, C. Draxler, C. Lindner, H. Zipse, "Versuche zur Experimentalvorlesung Organische Chemie", 2. korrigierte Auflage, Shaker Verlag, 2014. [ISBN 978-3-8440-2850-8] H. Zipse, "Grundlagen der Organischen Chemie" Shaker Verlag, 2014, 3. korrigierte Auflage. [ISBN 978-3-8440-2849-2] R. Tandon, T. Nigst, H. Zipse, "Inductive Effects through Alkyl Groups – How Long is Long Enough?" Eur. J. Org. Chem. 2013, 5423 - 5430. [DOI: 10.1002/ejoc.201300486] T. H. Gehrke, U. Lischke, K. L. Gasteiger, S. Schneider, S. Arnold, H. C. Müller, D. S. Stephenson, H. Zipse, T. Carell, "Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions" Nat. Chem. Biol. 2013, 9, 455 - 463. [DOI: 10.1038/nchembio.1254] J. Hioe, M. Mosch, D. M. Smith, H. Zipse, "Dissociation Energies of C(alpha)-H Bonds in Amino Acids - a Reexamination" RSC Advances 2013, 3, 12403 - 12408. [DOI: 10.1039/C3RA42115E] S. Schaffer, R. Tandon, H. Zipse, W. Siess, A. Schmidt, J. Jamasbi, E. Karshovska, W. Steglich, R. Lorenz, "Stereospecific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages" Biochem. Pharm. 2013, 86, 279 - 285. [DOI: 10.1016/j.bcp.2013.04.024] D. Sakic, F. Achrainer, V. Vrcek, H. Zipse, "The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine" Org. Biomol. Chem. 2013, 11, 4232 - 4239. [DOI: 10.1039/C3OB40219C] F. Achrainer, F. Barth, C. Draxler, C. Lindner, H. Zipse, "Versuche zur Experimentalvorlesung Organische Chemie," Shaker Verlag, 2013. [ISBN 978-3-8440-1777-9] H. Zipse, "Grundlagen der Organischen Chemie" Shaker Verlag, 2013, 2. korrigierte Auflage. [ISBN 978-3-8440-1885-1] R. Tandon, T. Unzner, T. A. Nigst, N. De Rycke, P. Mayer, B. Wendt, O. R. P. David, H. Zipse, "Annelated Pyridines as Highly Nucleophilic and Lewis-Basic Catalysts for Acylation Reactions" Chem. Eur. J. 2013, 19, 6435 - 6442. [DOI: 10.1002/chem.201204452]