Organic chemistry

Use of diazo compounds and azomethine imines in asymmetric synthesis Design and development of novel organocatalysts

"Enantioselective Formal Alkenylations of Imines Catalyzed by Axially Chiral Dicarboxylic Acid Using Vinylogous Aza-Enamines" T. Hashimoto, H. Kimura, K. Maruoka, Angew. Chem. Int. Ed. 2010, 49, 6844-6847 . "Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Aldehydes" T. Hashimoto, Y. Maeda, M. Omote, H. Nakatsu, K. Maruoka, J. Am. Chem. Soc. 2010, 132, 4076-4077. "α-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective α Alkylation of α-Alkyl-α-alkynyl Esters" T. Hashimoto, K. Sakata, K. Maruoka, Angew. Chem. Int. Ed. 2009, 48, 5014-5017 . "Stereoselective Synthesis of α-Alkyl-β-keto Imides via Asymmetric Redox C-C Bond Formation between α-Alkyl-α-diazocarbonyl Compounds and Aldehydes" T. Hashimoto, H. Miyamoto, Y. Naganawa, K. Maruoka, J. Am. Chem. Soc. 2009, 131, 11280-11281 . "Stereoselective Construction of Seven-Membered Rings with an All-Carbon Quaternary Center by Direct Tiffeneau-Demjanov-type Ring Expansion" T. Hashimoto, Y. Naganawa, K. Maruoka, J. Am. Chem. Soc. 2009, 131, 6614-6617. "Trans-Selective Asymmetric Aziridination of Diazoacetamides and N-Boc Imines Catalyzed by Axially Chiral Dicarboxylic Acid" T. Hashimoto, N. Uchiyama, K. Maruoka, J. Am. Chem. Soc. 2008, 130, 14380-14381. "Asymmetric Imino Aza-enamine Reaction Catalyzed by Axially Chiral Dicarboxylic Acid: Use of Arylaldehyde N,N-Dialkylhydrazones as Acyl Anion Equivalent" T. Hashimoto, M. Hirose, K.Maruoka, J. Am. Chem. Soc. 2008, 130, 7556-7557 . "Brønsted Acid-Catalyzed Insertion of Aryldiazoacetates to sp2 Carbon-CHO Bond: Facile Construction of Chiral All-Carbon Quaternary Center" T. Hashimoto, Y. Naganawa, K. Maruoka, J. Am. Chem. Soc. 2008, 130, 2434-2435 .

"Design of Axially Chiral Dicarboxylic Acid for Asymmetric Mannich Reaction of Arylaldehyde N-Boc Imines and Diazo Compounds" T. Hashimoto, K. Maruoka, J. Am. Chem. Soc. 2007, 129, 10054-10055.