Structural Biology Protein Crystallography

Mechanisms of biological macromolecular functions Alternation of biological macromolecular functions Development of protein crystallography techniques

"Structural characterization of the molecular events during a slow substrate-product transition in orotidine 5'-monophosphate decarboxylase." Fujihashi, M., Wei, L., Kotra, L.P. & Pai, E.F. (2009) J Mol Biol. 387, 1199-210 "Crystal structure of archaeal photolyase from Sulfolobus tokodaii with two FAD molecules: implication of a novel light-harvesting cofactor." Fujihashi, M., Numoto N, Kobayashi Y, Mizushima A, Tsujimura M, Nakamura A, Kawarabayasi Y, Miki K. (2007) J Mol Biol. 365, 903-10. "An unprecedented twist to ODCase catalytic activity"; Fujihashi, M., Bello, A.M., Poduch, E., Wei, L., Annedi, S.C., Pai, E.F.& Kotra, L.P. (2005). J Am Chem Soc 127, 15048-50. "Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites"; Fujihashi, M., Peapus, D.H., Kamiya, N., Nagata, Y.& Miki, K. (2003). Biochemistry 42, 11093-9. "Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase";

Fujihashi, M., Zhang, Y.W., Higuchi, Y., Li, X.Y., Koyama, T.& Miki, K. (2001). Proc Natl Acad Sci U S A 98, 4337-42.