Education Ph.D. Department of Chemistry, KAIST (1996) M.S. Department of Chemistry, KAIST (1992) B.S. Department of Chemistry (Cum Laude), KAIST (1990) Career Assistant & Associate Professor, 2004-present, Department of Chemistry, KAIST Postdoc Associate, 1999-2003, Department of Chemistry, Univ. of Wisconsin, Madison Senior Scientist, 1996-1999, Samsung Fine Chemicals R&D Center Academes and Society Korean chemical society Awards 2011 범부처 국가연구개발사업 우수성과 100선 선정 (국가과학기술위원회) 2011 Sehi Jang Excellent Research Award (Organic Chem. Division, Korean Chemical Society) 2011 Asian Core Program (ACP) Lectureship Award (Thailand) 2010 Best Lecturer Award (College of Natural Science, KAIST) 2010 The 4th KRIBB Poster Festival Innovation Award (KRIBB) 2010 Asian Core Program (ACP) Lectureship Award (Taiwan) 2008 Asian Core Program (ACP) Lectureship Award (Japan) 2008 Best Lecturer Award (Department of Chemistry, KAIST) 2007 Best Lecturer Award (College of Natural Science, KAIST) 2005 Synlett Journal Award (Thieme)

Organic Chemistry

Main research in our group is to create new foldamers (unnatural oligomers) that can mimic structures and functions of biopolymers such as peptides and nucleic acids. Foldamer research is motivated by many different goals ranging from and emerging diseases to the design of new materials for use in bionanotechnology. Research topics * Foldamers and Foldectures (Self-Assembled 3D Molecular Architectures) * Asymmetric Organic Synthesis, Antibiotics and Anticancer Drugs * Molecular Recognition, Noncovalent Interactions, PNA, Biomineralization

Foldecture as a Core Material with Anisotropic Surface Characteristics, Yoo, S.H.; Eom, T.; Kwon, S.; Gong, J.; Kim, J.; Cho, S.J.; Driver, R.W.; Lee, Y.; Kim, H.*; Lee, H.-S.*, J. Am. Chem. Soc., 137 (6), 2159-2162 (IF 11.444) (2015). Microtubes with Rectangular Cross-Section by the Self-Assembly of a short β-Peptide Foldamer, Kim, J.(co-first author); Kwon, S.(co-first author); Kim, S. H.; Lee, C.-K.; Lee, J.-H.; Cho, S. J.; Lee, H.-S*; Ihee, H.*, J. Am. Chem. Soc., 134, 20573-20576 (IF 11.444) (2012). Self-Assembled Peptide Architecture with a Tooth Shape: Folding into Shape, Kwon, S.; Shin, H. S.; Gong, J.; Eom, J. H.; Jeon, A.; Yoo, S. H.; Chung, I. S.; Cho, S.J.*; Lee, H.-S.*, J. Am. Chem. Soc., 133, 17618-17621 (IF 11.444) (2011). Unprecedented Molecular Architectures by the Controlled Self-Assembly of a β-Peptide Foldamer, Kwon, S.; Jeon, A.; Yoo, S. H.; Chung, I. S.; Lee, H.-S.* , Angew. Chem. Int. Ed. , 49, 8232-8236 (IF 11.336) (2010). Foldecture as a Core Material with Anisotropic Surface Characteristics, Yoo, S.H.; Eom, T.; Kwon, S.; Gong, J.; Kim, J.; Cho, S.J.; Driver, R.W.; Lee, Y.; Kim, H.*; Lee, H.-S.*, J. Am. Chem. Soc., 137 (6), 2159-2162 (IF 11.444) (2015). One-Pot Self-Templating Synthesis of Pt Hollow Nanostructures and Their Catalytic Properties for CO Oxidation, Choi, B.-S.; Kim, S. M.; Gong, J.; Lee, Y. W.; Kang, S. W.; Lee, H.-S.; Park, J. Y.*; Han, S. W.*, Chem.- Eur. J., 20(37), 11669-11674 (IF 5.696) (2014). A single-molecule dissection of ligand binding to a protein with intrinsic dynamics, Kim, E.; Lee, S.; Jeon, A.; Choi, J. M.; Lee, H.-S.; Hohng, S.; Kim, H.-S., Nat. Chem. Biol., 9, 313-318 (IF 13.217) (2013). Comparison and Contrast Analysis of Adsorption Geometries of Phenylalanine versus Tyrosine on Ge(100): The Effect of Nucleophilic Group on the Surface, Yang, S.; Lim, H.; Park, E. H.; Kim, Y.; Min, Y. H.; Lee, H.-S.*; Kim, S.*; Lee, H.*, J. Phys. Chem. C, 116(49), 25840-25845 (IF 4.835) (2012). Specific Serum Ig Recognizing Staphylococcal Wall Teichoic Acid Induces Complement-Mediated Opsonophagocytosis against Staphylococcus aureus, Jung, D.-J.; An, J.-H.; Kurokawa, K.; Jung, Y.-C.; Kim, M.-J.; Aoyagi, Y.; Matsushiita, M.; Takahashi, S.; Lee, H.-S.; Takahashi, K.; Lee, B.L., The Journal of Immunology, 189 (10), 4951-4959 (IF 5.362) (2012). A Pyrene-Imidazolium Derivative that Selectively Recognizes G-Quadruplex DNA, Kim, H. N.; Lee, E.-H.; Xu, Z.; Kim, H.-E.; Lee, H.-S.; Lee, H.-S.; Lee, J.-H.*; Yoon, J.*, Biomaterials, 33(7), 2282-2288 (IF 8.312) (2012). Microtubes with Rectangular Cross-Section by the Self-Assembly of a short β-Peptide Foldamer, Kim, J.(co-first author); Kwon, S.(co-first author); Kim, S. H.; Lee, C.-K.; Lee, J.-H.; Cho, S. J.; Lee, H.-S*; Ihee, H.*, J. Am. Chem. Soc., 134, 20573-20576 (IF 11.444) (2012). Evaporation-Induced Self-Assembly of trans-2-Aminocyclopentanecarboxylic Acid Hexamers, Kwon, S.; Kang, K.; Jeon, A.; Park, J. H.; Choi, I.S.*; Lee, H.-S.*, Tetrahedron, (SI: Chemistry of Foldamers, invited article), 68, 4368-4373 (IF 2.817) (2012). Self-Assembled Peptide Architecture with a Tooth Shape: Folding into Shape, Kwon, S.; Shin, H. S.; Gong, J.; Eom, J. H.; Jeon, A.; Yoo, S. H.; Chung, I. S.; Cho, S.J.*; Lee, H.-S.*, J. Am. Chem. Soc., 133, 17618-17621 (IF 11.444) (2011). A 93 kDa Twin Domain Serpin Has a Regulatory Function on the Beetle Toll Proteolytic Signaling Cascade, Jiang, R.; Zhang, B.; Kurokawa, K.; So, Y.-I.; Kim, E.-H.; Hwang, H.O.; Lee, J.-H.; Shiratsuchi, A.; Zhang, J.; Nakanishi, Y.; Lee, H.-S.*; Lee, B.L.*, J. Biol. Chem., 286(40), 35087-35095 (IF 4.6) (2011). A Nonpeptidic Reverse-Turn Scaffold Stabilized by Urea-Based Dual Intramolecular Hydrogen Bonding , Medda, A. K.; Park, C. M.; Jeon, A.; Kim, H.; Sohn, J.-H.;* Lee, H. -S.*, Org. Lett., 13(13), 3486-3489 (IF 6.324) (2011). Structure Modulation of Silica Microspheres in Bio-Inspired Silicification: Effects of TEOS Concentration, Park, J. H.; Choi, J. Y.; Park, T.; Yang, S. H.; Kwon, S. B.; Lee, H.-S.*; Choi, I. S.*, Chem. Asian J., 6, 1939-1942 (IF 3.935) (2011). Base-pair Opening Kinetics Study of the aegPNA:DNA Hydrid Duplex Containing a Site-specific GNA-like Chiral PNA Monomer, Seo, Y.-J.; Lim, J.; Lee, E.-H.; Ok, T.; Yoon, J.; Lee, J.-H.*; Lee, H.-S.*, Nucl. Acids Res., 39(16), 7329-7335 (IF 8.808) (2011). Unique X-ray Sheet Structure of 1,8-Bis(imidazolium) Anthracene and Its Application to Fluorescent Probe for DNA and DNase, Kim, H.N.; Lim, J.; Lee, H.N.; Ryu, J.-W.; Kim, M.J.; Lee, J.; Lee. D.-U.; Kim, Y.; Kim, S.-J.; Lee, K.D.*; Lee, H.-S.*; Yoon, J.*, Org. Lett. , 13, 1314-1317 (IF 6.324) (2011). γ3PNA: Peptide Analogue of Glycol Nucleic Acid, Ok, T.; Lee, J.; Lee, H.-S.*, Bull. Korean Chem. Soc., 32, 2863-2864 (IF 0.835) (2011).

GNA/aegPNA Chimera Loaded with RNA Binding Preference, Ok, T.; Lee, J.; Jung, C.; Lim, J.; Park, C.M.; Lee, J.-H.; Park, H. G.; Lee, H.-S.*, Chem. Asian. J. , 6, 1996-1999 (IF 3.935) (2011).