Dr. Larissa Shimoda is an Professor of Medicine in the Pulmonary and Critical Care Medicine Department. She studies pulmonary arterial responses to chronic hypoxia, hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Dr. Shimoda holds a bachelor’s degree, master’s degree and PhD, all in biomedical engineering, from Marquette University. She completed a fellowship at the Johns Hopkins University School of Medicine before joining the faculty. B.S., Marquette University (Wisconsin) (1990) M.S., Marquette University (Wisconsin) (1992) Ph.D., Marquette University (Wisconsin) (1995)

Oxidant-mediated lung injury; Hypoxic pulmonary vasoconstriction; Pulmonary arterial responses to chronic hypoxia

Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. Biochem J. 2014 Mar 1;458(2):203-11. doi: 10.1042/BJ20131350. PMID: 24328859 Shimoda LA, Laurie SS. HIF and pulmonary vascular responses to hypoxia. J Appl Physiol (1985). 2013 Dec 12. [Epub ahead of print] PMID: 24336881 Lai N, Lade J, Leggett K, Yun X, Baksh S, Chau E, Crow MT, Sidhaye V, Wang J, Shimoda LA. The Aquaporin 1 C-terminal Tail is Required for Migration and Growth of Pulmonary Arterial Myocytes. Am J Respir Cell Mol Biol. 2013 Dec 11. [Epub ahead of print] PMID: 24328827 Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. MK2 Mediates Apoptosis During Lung Vascular Permeability by Regulating Movement of Cleaved Caspase 3. Am J Respir Cell Mol Biol. 2013 Dec 4. [Epub ahead of print] PMID: 24304496 Polak J, Shimoda LA, Drager LF, Undem C, McHugh H, Polotsky VY, Punjabi NM. Intermittent hypoxia impairs glucose homeostasis in C57BL6/J mice: partial improvement with cessation of the exposure. Sleep. 2013 Oct 1;36(10):1483-90; 1490A-1490B. doi: 10.5665/sleep.3040. PMID: 24082307 Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L549-61. doi: 10.1152/ajplung.00081.2012. Epub 2013 Feb 15. PMID: 23418090 Shimoda LA, Laurie SS. Vascular remodeling in pulmonary hypertension. J Mol Med (Berl). 2013 Mar;91(3):297-309. doi: 10.1007/s00109-013-0998-0. Epub 2013 Jan 19. Review. PMID: 23334338 Shimoda LA. 55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. J Appl Physiol (1985). 2012 Nov;113(9):1343-52. doi: 10.1152/japplphysiol.00843.2012. Epub 2012 Aug 23. PMID: 22923506 Suson KD, Stec AA, Gearhart JP, Shimoda LA. Transforming growth factor-β1 mediates migration in cultured human control and exstrophy bladder smooth muscle cells. J Urol. 2012 Oct;188(4 Suppl):1528-33. doi: 10.1016/j.juro.2012.02.038. Epub 2012 Aug 19. PMID: 22910259 Suson KD, Stec AA, Shimoda LA, Gearhart JP. Initial characterization of exstrophy bladder smooth muscle cells in culture. J Urol. 2012 Oct;188(4 Suppl):1521-7. doi: 10.1016/j.juro.2012.02.028. Epub 2012 Aug 19. PMID: 22910242