BS, Microbiology and Biology, University of Michigan PhD, Microbiology, Michigan State University

biochemistry of RNA virus infection and innate immunity

Rao A. L. N., and C. Kao. 2015. The Brome mosaic virus 3’ untranslated sequence regulates RNA replication, recombination and virion assembly. Virus Res. 206, 46-52. Wen Y, X. Lin, B. Fan, C.T. Ranjith-Kumar, and C. Kao. 2015. The juxtamembrane sequence of the hepatitis C virus polymerase regulates RNA synthesis and affects sensitivity to active site allosteric inhibitors.? Virus Genes 51: 1-11. ? Kitayama M., H. Hoover, S. Middleton, and C. C. Kao. 2015. Brome mosaic virus infection of rice results in decreased accumulation of RNA1. Mol. Plant-Micro. Interact. 28: 626-632. Saha S., D. Singh, E. Raymond, R. Ganesan, G. Caviness, C. Grimaldi, J. Woska, D. Mennerich, S.-E. Brown, M. L. Mbow, and C. C. Kao. 2015. Signal transduction and intracellular trafficking by the interleukin 36 receptor. J. Biol. Chem. 290:23997-24006. Fan B., F. X. Reymond, K. Y. G.D. Syu, S. Middleton, G. Yi, K.Y. Lu, C. S. Chen, and C. C. Kao. 2015. Heterogeneous ribonucleoprotein K (hnRNP K) binds miR-122, a mature liver-specific microRNA required for Hepatitis C virus replication. Molec. Cell. Proteom. 14: 2878-2886. Jin Z., K. Tucker, X. Lin, C. Cheng Kao, K. Shaw, H. Tan, J. Symons, V. K.? Rajwanshi, N. Dyatkina, G. Wang, L. Beigelman, J. Deval. 2015. Biochemical evaluation of the inhibition properties of Favipiravir (T-705) and 2’-C-methyl-cytidine triphosphates against human and mouse norovirus RNA polymerases. Antimicr. Agents and Chemo. 59: 7504-7516. Tsvetkova I. B., G. Yi, Y. Yi, C. C. Kao, and B. G. Dragnea. 2015. Segmented GFP-like aptamer probes for functional imaging of viral genome trafficking. Virus Res. 210:291-297. Hu Z., X. Hu, S. He, H. J. Yim, J. Xiao, M. Swaroop, C. Tanega, Y. Zhang, G. Yi, C. Cheng Kao, J. Marugan, M. Ferrer, W. Zhang, N. Southall, and T. J. Liang. 2015. Identification of novel anti-HCV agents by a quantitative high throughput screen in a cell-based infection assay. Antiviral Res. 124:20-29.? Yi G., Wen Y., C. Shu, Q. Han, K. V. Konan, P. Li, and C. C. Kao. 2016. Genotype-specific inhibition of hepatitis C virus replication by cyclic GMP-AMP that activates STING-mediated immune responses. J. Virol. Oct 14. pii: JVI.01720-15. Rolfsson O, S. Middleton S. Manfield I, B. Fan B., R. Vaughan, S. J. White, K, Toropova, N. A. Ranson, E. Dykeman, R. Twarock, J. Ford, C. C. Kao, and P.G. Stockley. 2016. Direct evidence for packaging signal-mediated assembly of bacteriophage MS2. J. Mol. Biol. (in press).