B.S. (2000) University of Pittsburgh - Biological Sciences Ph.D. (2005) University of Pittsburgh - Biochemistry and Enzymology Postdoctoral Fellowship (2011) Dartmouth College - Structural Biology and Biophysical Chemistry

development of a metal switch for controlling the activity of P-loop NTPases; kinetic and thermodynamic investigations of unconventional kinesin-microtubule systems; high resolution structural and mechanistic studies of tubulin-protein interactions

Cochran JC, Thompson M, and Kull FJ (2013) “Metal Switch Controlled Myosin II from Dictyostelium discoideum Supports Closure of Switch 1 During ATP Binding is Coupled to Myosin Detachment from Actin Filaments” J Biol Chem In Review Cochran JC and Kull FJ (2013) "A Molecular Motor Finds Its Track" Nat Struct Mol Biol "News and Views" In Press Audu CO, Cochran JC, Pellegrini M, and Mierke DF (2013) “Recombinant production of TEV cleavable human parathyroid hormone” J Pep Sci 19: 504-510 Waitzman JS, Larson AG, Cochran JC, Naber N, Cooke R, Kull FJ, Pate E, and Rice SE (2011) “The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5” Biophys J 101: 2760-2769 Cochran JC, Zhao YC, Wilcox DE, and Kull FJ (2011) “A Metal Switch for Controlling the Activity of Molecular Motor Proteins” Nat Struct Mol Biol 19: 122-127 Zhao YC, Kull FJ, and Cochran JC (2010) “Modulation of the Kinesin ATPase Cycle by Neck Linker Docking and Microtubule Binding” J Biol Chem 285: 25213-25220 Cochran JC, Sindelar CV, Mulko NK, Collins KA, Kong SE, Hawley RS, and Kull FJ (2009) “ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement” Cell 136: 110-122 Cochran JC and Kull FJ (2008) “Kinesin motors: no strain, no gain” Cell 134: 918-919 Cochran JC, Krzysiak TC, and Gilbert SP (2006) “Pathway of ATP hydrolysis by monomeric kinesin Eg5” Biochemistry 45: 12334-12344 Cochran JC and Gilbert SP (2005) “ATPase mechanism of Eg5 in the absence of microtubules: Insight into microtubule activation and allosteric inhibition by monastrol” Biochemistry 44: 16633-16648 Cochran JC, Gatial JE III, Kapoor TM, and Gilbert SP (2005) “Monastrol inhibition of the mitotic kinesin Eg5” J Biol Chem 280: 12658-12667 Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, and Gilbert SP (2004) “Mechanistic analysis of the mitotic kinesin Eg5” J Biol Chem 279: 38861-38870 Skiniotis G, Cochran JC, Muller J, Mandelkow E, Gilbert SP, and Hoenger A (2004) “Modulation of kinesin binding by the C-termini of tubulin” EMBO J 23: 989-999 Coughlan CM, Walker JL, Cochran JC, Wittrup KD, and Brodsky JL (2004) “Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggest post-endoplasmic reticulum protein quality control” J Biol Chem 279: 15289-15297