Research Appointments 2017-date Satellite Group Leader, The Francis Crick Institute 2014-date Professor of Chemical Biology, Imperial College London Prior positions: 2012-2014 Reader in Chemical Biology, Imperial College London; 2010-2012 Senior Lecturer in Chemical Biology, Imperial College London; 2006-2011 BBSRC David Phillips Research Fellow, Imperial College London; 2004-2006 Research Associate, Department of Chemistry, Imperial College London; 2002-2003 Howard Trust Research Fellow, Pasteur Institute, Paris, France; 2000-2002 Royal Exhibition of 1851 Research Fellow, Ecole Polytechnique, Paris, France. Degrees Held: 2000 Ph.D. Organic Chemistry, University of Cambridge, in the group of Prof Steven V. Ley; 1996 B.Sc. Chemistry, 1st Class Honours, University of Durham

Our research lies at the interface between organic chemistry, the life sciences and medicine, in the fields of chemical biology and chemical proteomics. The unifying theme of our work is the design and application of chemical approaches to understand and manipulate living systems, with an emphasis on processes important to disease. Related to this theme, our group also undertakes research in medicinal chemistry and chemical synthesis/modification of proteins and peptides.

Beard R, Stucki A, Schmitt M, Py G, Grundschober C, Gee AD, Tate EWclose, 2018, Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs., Bioorg Med Chem Craven GB, Affron DP, Allen CE, Matthies S, Greener JG, Morgan RML, Tate EW, Armstrong A, Mann DJclose, 2018, High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 57, Pages: 5257-5261, ISSN: 1433-7851 Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadayizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJclose, 2018, Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum, ACS INFECTIOUS DISEASES, Vol: 4, Pages: 523-530, ISSN: 2373-8227 Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Perez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedan A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EWclose, 2018, Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus, NATURE CHEMISTRY, Vol: 10, Pages: 599-606, ISSN: 1755-4330 Pollard DJ, Berger CN, So EC, Yu L, Hadavizadeh K, Jennings P, Tate EW, Choudhary JS, Frankel Gclose, 2018, Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ, MBIO, Vol: 9, ISSN: 2150-7511 Ritzefeld M, Wright MH, Tate EW, 2018, New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness, PARASITOLOGY, Vol: 145, Pages: 157-174, ISSN: 0031-1820 Schlott AC, Holder AA, Tate EW, 2018, N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action, ACS INFECTIOUS DISEASES, Vol: 4, Pages: 449-457, ISSN: 2373-8227 Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EWclose, 2017, Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane, CHEMICAL COMMUNICATIONS, Vol: 53, Pages: 5182-5185, ISSN: 1359-7345 Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PPclose, 2017, Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology, JOURNAL OF CELL SCIENCE, Vol: 130, Pages: 903-915, ISSN: 0021-9533 Gorlitz F, Kelly DJ, Warren SC, Alibhai D, West L, Kumar S, Alexandrov Y, Munro I, Garcia E, McGinty J, Talbot C, Serwa RA, Thinon E, da Paola V, Murray EJ, Stuhmeier F, Neil MAA, Tate EW, Dunsby C, French PMWclose, 2017, Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X