Prof. Joshua Edel received his PhD on the development of single molecule detection within microfluidic systems at Imperial College London in 2003. He then performed postdoctoral research in nanobiotechnology at Cornell University within the School of Applied and Engineering Physics. In 2005 he was awarded a research fellowship in single molecule biophysics at the Rowland Institute at Harvard University. In July 2006 he joined Imperial College London within the Department of Chemistry and Institute of Biomedical Engineering as a lecturer. Joshua is currently a Professor in the Department of Chemistry and in 2011 he was awarded a prestigious ERC Starting Grant on “Nanoporous Membranes for High Throughput Rare Event Bioanalysis” and in 2016 he was awarded an ERC Consolidator Grant related to the development of selective single molecule biosensors.

Analytical Sensors plays a crucial role in today’s highly demanding exploration and development of new detection strategies. Whether it be medicine, biochemistry, bioengineering, or analytical chemistry the goals are essentially the same: 1) improve selectivity & sensitivity, 2) maximize throughput, 3) and reduce the instrumental footprint. In order to address these key challenges, the analytical community has borrowed technologies and design philosophies which has been used by the semiconductor industry over the past 20 years. By doing so, key technological advances have been made which include the miniaturization of sensors and signal processing components which allows for the efficient detection of nanoscale object. One can imagine that by decreasing the dimensions of a sensor to a scale similar to that of a nanoscale object, the ultimate in sensitivity can potentially be achieved - the detection of single molecules. Current research activities taking place in the group include: Single molecule biological screening using electrical and optical methods Early stage diagnostics including cancer and neurodegenerative disorders Single cell screening Development of novel DNA sequencing and nanopore platforms Electrovariable plasmonics

Kwan Z, Paulose Nadappuram B, Leung MM, Mohagaonkar S, Li A, Amaradasa KS, Chen J, Rothery S, Kibreab I, Fu J, Sanchez-Alonso JL, Mansfield CA, Subramanian H, Kondrashov A, Wright PT, Swiatlowska P, Nikolaev VO, Wojciak-Stothard B, Ivanov AP, Edel JB, Gorelik Jclose, 2023, Microtubule-Mediated Regulation of β2AR Translation and Function in Failing Hearts., Circ Res, Vol: 133, Pages: 944-958 Liu Y, Wang X, Campolo G, Teng X, Ying L, Edel JB, Ivanov APclose, 2023, Single-Molecule Detection of α-Synuclein Oligomers in Parkinson's Disease Patients Using Nanopores., ACS Nano Jiang T, Yi L, Liu X, Ivanov AP, Edel JB, Tang Lclose, 2023, Fabrication of electron tunneling probes for measuring single-protein conductance, Nature Protocols, Vol: 18, Pages: 2579-2599, ISSN: 1750-2799 Edel J, Ma Y, Kornyshev A, 2023, Electrochemical photonics: a pathway towards electrovariable optical metamaterials, Nanophotonics, Vol: 12, Pages: 2717-2744, ISSN: 2192-8606 Sahota A, Monteza Cabrejos A, Kwan Z, Paulose Nadappuram B, Ivanov AP, Edel JBclose, 2023, Recent advances in single-cell subcellular sampling., Chemical Communications, Vol: 59, Pages: 5312-5328, ISSN: 1359-7345 Wang X, Thomas T-M, Ren R, Zhou Y, Zhang P, Li J, Cai S, Liu K, Ivanov AP, Herrmann A, Edel JBclose, 2023, Nanopore detection using supercharged polypeptide molecular carriers, Journal of the American Chemical Society, Vol: 145, Pages: 6371-6382, ISSN: 0002-7863 Wojciak-Stothard B, Ainscough AJ, Smith TJ, Haensel M, Rhodes CJ, Fellows A, Whitwell HJ, Vasilaki E, Grey K, Freeman A, Howard LS, Wharton J, Dunmore B, Upton PD, Wilkins MR, Edel Jclose, 2022, An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis, Communications Biology, Vol: 5, Pages: 1-15, ISSN: 2399-3642 Fried JP, Swett JL, Nadappuram BP, Fedosyuk A, Gee A, Dyck OE, Yates JR, Ivanov AP, Edel JB, Mol JAclose, 2022, Localised solid-state nanopore fabrication via controlled breakdown using on-chip electrodes, Nano Research, Vol: 15, Pages: 9881-9889, ISSN: 1998-0124 Tang L, Yi L, Jiang T, Ren R, Paulose Nadappuram B, Zhang B, Wu J, Liu X, Lindsay S, Ivanov A, Edel Jclose, 2022, Measuring conductance switching in single proteins using quantum tunneling, Science Advances, Vol: 8, Pages: 1-8, ISSN: 2375-2548 Upton RL, Fedosyuk A, Edel JB, Crick CRclose, 2021, Carbon Nanofiber/SiO2 Nanoparticle/HDPE Composites as Physically Resilient and Submersible Water-Repellent Coatings on HDPE Substrates, ACS APPLIED NANO MATERIALS, Vol: 4, Pages: 10090-10102 Ren R, Sun M, Goel P, Cai S, Kotov NA, Kuang H, Xu C, Ivanov A, Edel JBclose, 2021, Single-molecule binding assay using nanopores and dimeric NP conjugates, Advanced Materials, Vol: 33, ISSN: 0935-9648 Fried JP, Swett JL, Nadappuram BP, Fedosyuk A, Sousa PM, Briggs DP, Ivanov AP, Edel JB, Mol JA, Yates JRclose, 2021, Understanding electrical conduction and nanopore formation during controlled breakdown, Small, Vol: 17, Pages: 1-9, ISSN: 1613-6810 Oh S-H, Altug H, Jin X, Low T, Koester SJ, Ivanov AP, Edel JB, Avouris P, Strano MSclose, 2021, Nanophotonic biosensors harnessing van der Waals materials, NATURE COMMUNICATIONS, Vol: 12, ISSN: 2041-1723 Al Sulaiman D, Gatehouse A, Ivanov AP, Edel JB, Ladame Sclose, 2021, Length-Dependent, Single-Molecule Analysis of Short Double-Stranded DNA Fragments through Hydrogel-Filled Nanopores: A Potential Tool for Size Profiling Cell-Free DNA, ACS APPLIED MATERIALS & INTERFACES, Vol: 13, Pages: 26673-26681, ISSN: 1944-8244 Cai S, Pataillot-Meakin T, Shibakawa A, Ren R, Bevan C, Ladame S, Ivanov A, Edel Jclose, 2021, Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum, Nature Communications, Vol: 12, ISSN: 2041-1723 Wojciak-Stothard B, Ainscough A, Smith T, Rhodes C, Fellows A, Howard L, Wharton J, Wilkins M, Edel Jclose, 2021, A MICROFLUIDIC CHIP FOR PULMONARY ARTERIAL HYPERTENSION Fried JP, Swett JL, Nadappuram BP, Mol JA, Edel JB, Ivanov AP, Yates JRclose, 2021, In situ solid-state nanopore fabrication., Chemical Society Reviews, ISSN: 0306-0012 Tang L, Paulose Nadappuram B, Cadinu P, Zhao Z, Xue L, Yi L, Ren R, Wang J, Ivanov A, Edel Jclose, 2021, Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations, Nature Communications, Vol: 12, Pages: 1-8, ISSN: 2041-1723 Zhao M, Yu J, Zhang X, Li Z, Ding Y, Edel JB, Ma Y, Li Hclose, 2021, Tuning interfacial energy barriers in heterojunctions for anti‐interference sensing, Advanced Functional Materials, Vol: 31, ISSN: 1616-301X Vilar Compte R, Summers P, Lewis B, Gonzalez-Garcia J, Porreca RM, Lim A, Cadinu P, Martin-Pintado N, Mann D, Edel J, Vannier JB, Kuimova M, Vilar Compte Rclose, 2021, Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy, Nature Communications, Vol: 12, ISSN: 2041-1723 Ren R, Wang X, Cai S, Korchev Y, Ivanov A, Edel Jclose, 2020, Selective sensing of proteins using aptamer functionalised nanopore extended field-effect transistors, Small Methods, Vol: 4, Pages: 1-8, ISSN: 2366-9608 Ma Y, Sikdar D, He Q, Kho D, Kucernak AR, Kornyshev AA, Edel JBclose, 2020, Self-assembling two-dimensional nanophotonic arrays for reflectivity-based sensing, Chemical Science, Vol: 11, Pages: 9563-9570, ISSN: 2041-6520 Xue L, Yamazaki H, Ren R, Wanunu M, Ivanov AP, Edel JBclose, 2020, Solid-state nanopore sensors, Nature Reviews Materials, Vol: 5, Pages: 931-951, ISSN: 2058-8437 Wang X, Wilkinson MD, Lin X, Ren R, Willison KR, Ivanov AP, Baum J, Edel JBclose, 2020, Correction: Single-molecule nanopore sensing of actin dynamics and drug binding, Chemical Science, Vol: 11, Pages: 8036-8038, ISSN: 2041-6520 Clark R, Nawawi MA, Dobre A, Pugh D, Liu Q, Ivanov AP, White AJP, Edel JB, Kuimova MK, McIntosh AJS, Welton Tclose, 2020, The effect of structural heterogeneity upon the microviscosity of ionic liquids, Chemical Science, Vol: 11, Pages: 6121-6133, ISSN: 2041-6520 Cadinu P, Kang M, Paulose Nadappuram B, Ivanov A, Edel JBclose, 2020, Individually addressable multi-nanopores for single-molecule targeted operations, Nano Letters, Vol: 20, Pages: 2012-2019, ISSN: 1530-6984 Ma Y, Sikdar D, Fedosyuk A, Velleman L, Klemme DJ, Oh S-H, Kucernak ARJ, Kornyshev AA, Edel JBclose, 2020, Electrotunable nanoplasmonics for amplified surface enhanced Raman spectroscopy, ACS Nano, Vol: 14, Pages: 328-336, ISSN: 1936-0851 Wang X, Wilkinson MD, Lin X, Ren R, Willison KR, Ivanov A, Baum J, Edel Jclose, 2020, Single-molecule nanopore sensing of actin dynamics and drug binding, Chemical Science, Vol: 11, Pages: 970-979, ISSN: 2041-6520 Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff P, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Gorelkin P, Majouga A, Weiss D, Edwards C, Ivanov A, Klenerman D, Sviderskaya E, Edel J, Korchev Yclose, 2019, High-resolution label-free 3D mapping of extracellular pH of single living cells, Nature Communications, Vol: 10, Pages: 1-9, ISSN: 2041-1723 Ma Y, Sikdar D, Fedosyuk A, Velleman L, Zhao M, Tang L, Kornyshev AA, Edel JBclose, 2019, An auxetic thermo-responsive nanoplasmonic optical switch., ACS Applied Materials and Interfaces, ISSN: 1944-8244 Kubánková M, Lin X, Albrecht T, Edel JB, Kuimova MKclose, 2019, Rapid fragmentation during seeded lysozyme aggregation revealed at the single molecule level, Analytical Chemistry, Vol: 91, Pages: 6880-6886, ISSN: 0003-2700 Cai S, Sze YYJ, Ivanov A, Edel Jclose, 2019, Small molecule electro-optical binding assay using nanopores, Nature Communications, Vol: 10, Pages: 1-9, ISSN: 2041-1723 Paulose Nadappuram B, Cadinu P, Barik A, Ainscough A, Devine M, Kang M, Gonzalez-Garcia J, Kittler J, Willison K, Vilar Compte R, Actis P, Wojciak-Stothard B, Oh S-H, Ivanov A, Edel JBclose, 2019, Nanoscale tweezers for single-cell biopsies, Nature Nanotechnology, Vol: 14, Pages: 80-88, ISSN: 1748-3387 Ma Y, Zagar C, Klemme DJ, Sikdar D, Velleman L, Montelongo Y, Oh SH, Kucernak AR, Edel JB, Kornyshev AAclose, 2018, A tunable nanoplasmonic mirror at an electrochemical interface, ACS Photonics, Vol: 5, Pages: 4604-4616, ISSN: 2330-4022 Xue L, Cadinu P, Paulose Nadappuram B, Kang M, Ma Y, Korchev Y, Ivanov A, Edel Jclose, 2018, Gated single-molecule transport in double-barreled nanopores, ACS Applied Materials and Interfaces, Vol: 10, Pages: 38621-38629, ISSN: 1944-8244 Al Sulaiman D, Cadinu P, Ivanov AP, Edel JB, Ladame Sclose, 2018, Chemically modified hydrogel-filled nanopores: a tunable platform for single-molecule sensing, Nano Letters: a journal dedicated to nanoscience and nanotechnology, Vol: 18, Pages: 6084-6093, ISSN: 1530-6984 Ivanov AP, Edel JB, 2018, Scissoring genes with light, NATURE CHEMISTRY, Vol: 10, Pages: 800-801, ISSN: 1755-4330 Rakers V, Cadinu P, Edel JB, Vilar Rclose, 2018, Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays, Chemical Science, Vol: 9, Pages: 3459-3469, ISSN: 2041-6520 Cadinu P, Campolo G, Pud S, Yang W, Edel J, Dekker C, Ivanov Aclose, 2018, Double barrel nanopores as a new tool for controlling single-molecule transport, Nano Letters, Vol: 18, Pages: 2738-2745, ISSN: 1530-6984 Kornyshev AA, Sikdar D, Edel JB, Weir Hclose, 2018, Towards Electrotuneable Nanoplasmonic Fabry–Perot Interferometer, Scientific Reports, Vol: 8, ISSN: 2045-2322 Peveler WJ, Noimark S, Al-Azawi H, Hwang GB, Crick CR, Allan E, Edel JB, Ivanov AP, MacRobert AJ, Parkin IPclose, 2018, Covalently attached antimicrobial surfaces using BODIPY: improving efficiency and effectiveness, ACS Applied Materials and Interfaces, Vol: 10, Pages: 98-104, ISSN: 1944-8244 Aizpurua J, Arnolds H, Baumberg J, Bruzas I, Chikkaraddy R, Chisanga M, Dawson P, Deckert V, Delfino I, de Nijs B, Di Martino G, Edel J, Fleming H, Gawinkowski S, Giorgis F, Goodacre R, Graham D, Hardy M, Heck C, Heeg S, Hewitt K, Jamieson L, Keeler A, Krolikowska A, Kuttner C, Lidgi-Guigui N, Lightner C, Lombardi J, Mahajan S, Sabanes NM, Masson J-F, Mueller NS, Muhamadali H, Murakoshi K, Popp J, Porter M, Reich S, Schatz G, Tian Z-Q, Tripathi A, Van Duyne R, Wang X, Wark A, Willets KK, Willner Mclose, 2017, Ultrasensitive and towards single molecule SERS: general discussion, FARADAY DISCUSSIONS, Vol: 205, Pages: 291-330, ISSN: 1359-6640 Barik A, Zhang Y, Grassi R, Paulose Nadappuram B, Edel JB, Low T, Koester SJ, Oh SHclose, 2017, Graphene-edge dielectrophoretic tweezers for trapping of biomolecules, Nature Communications, Vol: 8, Pages: 1-9, ISSN: 2041-1723 Sze JYY, Ivanov AP, Cass AEG, Edel JBclose, 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, Nature Communications, Vol: 8, Pages: 1-10, ISSN: 2041-1723 Montelongo Y, Sikdar D, Ma Y, McIntosh AJS, Velleman L, Kucernak AR, Edel JB, Kornyshev AAclose, 2017, Electrotunable nanoplasmonic liquid mirror., Nature materials, Vol: 16, Pages: 1127-1135, ISSN: 1476-1122 Crick CR, Albella P, Kim H-J, Ivanov AP, Kim K-B, Maier SA, Edel JBclose, 2017, Low-Noise Plasmonic Nanopore Biosensors for Single Molecule Detection at Elevated Temperatures, ACS Photonics, Vol: 4, Pages: 2835-2842, ISSN: 2330-4022 Cadinu P, Cadinu P, Paulose Nadappuram B, Lee DJ, Sze JYY, Campolo G, Zhang Y, Shevchuk A, Ladame S, Albrecht T, Korchev Y, Ivanov AP, Edel JBclose, 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge., Nano letters, Vol: 17, Pages: 6376-6384, ISSN: 1530-6984 Ren R, Zhang Y, Paulose Nadappuram B, Akpinar B, Klenerman D, Ivanov AP, Edel JB, Korchev Yclose, 2017, Nanopore extended field effect transistor for selective single molecule biosensing, Nature Communications, Vol: 8, Pages: 1-9, ISSN: 2041-1723 lauri A, Velleman L, Xiao X, Cortes E, Edel JB, Giannini V, Rakovich A, Maier SAclose, 2017, 3D Confocal Raman Tomography to Probe Field Enhancements inside Supercluster Metamaterials, ACS Photonics, Vol: 4, Pages: 2070-2077, ISSN: 2330-4022 Velleman L, Scarabelli L, Sikdar D, Kornyshev AA, Liz-Marzan LM, Edel JBclose, 2017, Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation, Faraday Discussions, Vol: 205, Pages: 67-83, ISSN: 1364-5498 Lin X, Ivanov AP, Edel JB, 2017, Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles, Chemical Science, Vol: 8, Pages: 3905-3912, ISSN: 2041-6539 Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvonen M, Edel JB, Kaminski CF, Hollfelder Fclose, 2017, Quantitative affinity determination by fluorescence anisotropy measurements of individual nanoliter droplets, Analytical Chemistry, Vol: 89, Pages: 1092-1101, ISSN: 0003-2700 Kim M, Ivanov A, Edel J, 2017, Nanofluidics Preface, NANOFLUIDICS, 2ND EDITION, Editors: Edel, Ivanov, Kim, Publisher: ROYAL SOC CHEMISTRY, Pages: VII-IX, ISBN: 978-1-84973-404-2 Velleman L, Sikdar D, Turek V, Kucernak A, Roser SJ, Kornyshev AA, Edel JBclose, 2016, Tuneable 2D self-assembly of plasmonic nanoparticles at liquid | liquid interfaces, Nanoscale, Vol: 8, Pages: 19229-19241, ISSN: 2040-3372 Panich S, Sleiman MH, Steer I, Ladame S, Edel JBclose, 2016, Real-Time Monitoring of Ligand Binding to G-Quadruplex and Duplex DNA by Whispering Gallery Mode Sensing, ACS Sensors, Vol: 1, Pages: 1097-1102, ISSN: 2379-3694 Crick CR, Noimark S, Peveler WJ, Bear JC, Ivanov AP, Edel JB, Parkin IPclose, 2016, Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging, Jove-Journal of Visualized Experiments, Vol: 113, ISSN: 1940-087X Sikdar D, Hasan SB, Urbakh M, Edel JB, Kornyshev AAclose, 2016, Unravelling the optical responses of nanoplasmonic mirror-on-mirror metamaterials., Physical Chemistry Chemical Physics, Vol: 18, Pages: 20486-20498, ISSN: 1463-9084 Freedman KJ, Crick CR, Albella P, Barik A, Ivanov AP, Maier SA, Oh SH, Edel JBclose, 2016, On-Demand Surface and Tip Enhanced Raman Spectroscopy Using Dielectrophoretic Trapping and Nanopore Sensing, ACS Photonics, Vol: 3, Pages: 1036-1044, ISSN: 2330-4022 Elani Y, Solvas XC, Edel JB, Law RV, Ces Oclose, 2016, Microfluidic generation of encapsulated droplet interface bilayer networks (multisomes) and their use as cell-like reactors., Chemical Communications, Vol: 52, Pages: 5961-5964, ISSN: 1364-548X Bougot-Robin K, Paget J, Atkins SC, Edel JBclose, 2016, Optimization and Design of an Absorbance Spectrometer Controlled Using a Raspberry Pi To Improve Analytical Skills, Journal of Chemical Education, Vol: 93, Pages: 1232-1240, ISSN: 0021-9584