James Bull graduated from the University of Cambridge in 2001 with a First Class Honours MSci degree in Natural Sciences, Chemistry and the Raphael Prize for Organic Chemistry. He then spent a year working at GlaxoSmithKline Stevenage as a Research Scientist in the Medicinal Chemistry Department. He returned to Cambridge in 2003 to undertake PhD research with Professor Steven V Ley. He completed the total synthesis of bisoxazole antifungal natural product bengazole A and analogues. In 2007 he joined the group of Professor André B. Charette as a Postdoctoral Fellow at Université de Montréal, Canada. Here he developed an intramolecular Simmons-Smith cyclopropanation reaction. In 2009 he began independent research at Imperial College London as a Ramsay Memorial Research Fellow (2009-2011), working in the laboratories of Professor Alan Armstrong. From 2011 to 2015 Dr Bull held an EPSRC Career Acceleration Fellowship on "Novel strategies to access chiral heterocycles as potential lead compounds in drug discovery". In January 2016 Dr Bull started a Royal Society University Research Fellowship

Small ring synthesis Fragments and lead-like compounds Catalysis C–H Functionalisation Carbenoid reagents Target Synthesis

Piticari A-S, Antermite D, Higham J, Moore H, Webster M, Bull Jclose, 2022, Stereoselective Palladium-Catalyzed C(sp3)–H Mono-Arylation of Piperidines and Tetrahydropyrans with a C(4) Directing Group, Advanced Synthesis and Catalysis, ISSN: 1615-4150 Rojas J, Croft R, Sterling A, Briggs E, Antermite D, Schmitt D, Blagojevic L, Haycock P, White A, Duarte F, Choi C, Mousseau J, Bull Jclose, 2022, Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides, Nature Chemistry, Vol: 14, Pages: 160-169, ISSN: 1755-4330 Andresini M, Tota A, Degennaro L, Bull JA, Luisi Rclose, 2021, Synthesis and Transformations of NH‐Sulfoximines, Chemistry – A European Journal, Vol: 27, Pages: 17293-17321, ISSN: 0947-6539 Dubois M, Croft R, Ding Y, Choi C, Owen D, Bull J, Mousseau Jclose, 2021, Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis, RSC Medicinal Chemistry, Vol: 12, Pages: 2045-2052, ISSN: 2632-8682 Rojas J, Bull J, 2021, Oxetanes and Oxetenes—Monocyclic, Comprehensive Heterocyclic Chemistry PCraven GB, Briggs EL, Zammit CM, McDermott A, Greed S, Affron DP, Leinfellner C, Cudmore HR, Tweedy RR, Luisi R, Bull JA, Armstrong Aclose, 2021, Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides, The Journal of Organic Chemistry, Vol: 86, Pages: 7403-7424, ISSN: 0022-3263 Boddy A, Bull J, 2021, Stereoselective synthesis and applications of spirocyclic oxindoles, Organic Chemistry Frontiers, Vol: 8, Pages: 1026-1084, ISSN: 2052-4110 Tota A, Colella M, Carlucci C, Aramini A, Clarkson G, Degennaro L, Bull JA, Luisi Rclose, 2021, N−N Bond Formation Using an Iodonitrene as an Umpolung of Ammonia: Straightforward and Chemoselective Synthesis of Hydrazinium Salts, Advanced Synthesis and Catalysis, Vol: 363, Pages: 194-199, ISSN: 1615-4150 Greed S, Briggs E, Idiris F, White A, Lücking U, Bull Jclose, 2020, Synthesis of highly enantioenriched sulfonimidoyl fluorides and sulfonimidamides by stereospecific SuFEx reaction, Chemistry: A European Journal, Vol: 26, Pages: 12533-12538, ISSN: 0947-6539 Higham J, Bull JA, 2020, Transient imine directing groups for the C–H functionalisation of aldehydes, ketones and amines: an update 2018-2020, Organic and Biomolecular Chemistry, Vol: 18, Pages: 7291-7315, ISSN: 1477-0520 Green SP, Wheelhouse KM, Payne AD, Hallett JP, Miller PW, Bull JAclose, 2020, On the Use of Differential Scanning Calorimetry for Thermal Hazard Assessment of New Chemistry: Avoiding Explosive Mistakes, Angewandte Chemie International Edition, Vol: 59, Pages: 15798-15802, ISSN: 1433-7851 Dubois MAJ, Smith MA, White AJP, Lee Wei Jie A, Mousseau JJ, Choi C, Bull JAclose, 2020, Short Synthesis of Oxetane and Azetidine 3-Aryl-3-carboxylic Acid Derivatives by Selective Furan Oxidative Cleavage, Organic Letters, Vol: 22, Pages: 5279-5283, ISSN: 1523-7060 Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux Eclose, 2020, Chemical and structural investigation of the paroxetine-human serotonin transporter complex, eLife, Vol: 9, ISSN: 2050-084X Tota A, Carlucci C, Pisano L, Cutolo G, Clarkson GJ, Romanazzi G, Degennaro L, Bull JA, Rollin P, Luisi Rclose, 2020, Synthesis of glycosyl sulfoximines by a highly chemo- and stereoselective NH- and O-transfer to thioglycosides, Organic & Biomolecular Chemistry, Vol: 18, Pages: 3893-3897, ISSN: 1477-0520 Higham J, Bull JA, 2020, Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(IV) oxide, Chemical Communications, Vol: 56, Pages: 4587-4590, ISSN: 1359-7345 St John-Campbell S, White AJP, Bull JA, 2020, Methylene C(sp3)–H β,β′-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand, Organic Letters, Vol: 22, Pages: 1807-1812, ISSN: 1523-7060 Green S, Wheelhouse K, Payne A, Hallett J, Miller P, Bull Jclose, 2020, Thermal stability and explosive hazard assessment of diazo compounds and diazo transfer reagents, Organic Process Research and Development, Vol: 24, Pages: 67-84, ISSN: 1083-6160 Brown P, Tan A-C, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T, Sorzano CO, Yeung AWK, Engel MS, Chandrasekaran AR, Muth T, Staege MS, Daulatabad SV, Widera D, Zhang J, Meule A, Honjo K, Pourret O, Yin C-C, Zhang Z, Cascella M, Flegel WA, Goodyear CS, van Raaij MJ, Bukowy-Bieryllo Z, Campana LG, Kurniawan NA, Lalaouna D, Huttner FJ, Ammerman BA, Ehret F, Cobine PA, Tan E-C, Han H, Xia W, McCrum C, Dings RPM, Marinello F, Nilsson H, Nixon B, Voskarides K, Yang L, Costa VD, Bengtsson-Palme J, Bradshaw W, Grimm DG, Kumar N, Martis E, Prieto D, Sabnis SC, Amer SEDR, Liew AWC, Perco P, Rahimi F, Riva G, Zhang C, Devkota HP, Ogami K, Basharat Z, Fierz W, Siebers R, Tan K-H, Boehme KA, Brenneisen P, Brown JAL, Dalrymple BP, Harvey DJ, Ng G, Werten S, Bleackley M, Dai Z, Dhariwal R, Gelfer Y, Hartmann MD, Miotla P, Tamaian R, Govender P, Gurney-Champion OJ, Kauppila JH, Zhang X, Echeverria N, Subhash S, Sallmon H, Tofani M, Bae T, Bosch O, Cuiv PO, Danchin A, Diouf B, Eerola T, Evangelou E, Filipp FV, Klump H, Kurgan L, Smith SS, Terrier O, Tuttle N, Ascher DB, Janga SC, Schulte LN, Becker D, Browngardt C, Bush SJ, Gaullier G, Ide K, Meseko C, Werner GDA, Zaucha J, Al-Farha AA, Greenwald NF, Popoola SI, Rahman MS, Xu J, Yang SY, Hiroi N, Alper OM, Baker CI, Bitzer M, Chacko G, Debrabant B, Dixon R, Forano E, Gilliham M, Kelly S, Klempnauer K-H, Lidbury BA, Lin MZ, Lynch I, Ma W, Maibach EW, Mather DE, Nandakumar KS, Ohgami RS, Parchi P, Tressoldi P, Xue Y, Armitage C, Barraud P, Chatzitheochari S, Coelho LP, Diao J, Doxey AC, Gobet A, Hu P, Kaiser S, Mitchell KM, Salama MF, Shabalin IG, Song H, Stevanovic D, Yadollahpour A, Zeng E, Zinke K, Alimba CG, Beyene TJ, Cao Z, Chan SS, Gatchell M, Kleppe A, Piotrowski M, Torga G, Woldesemayat AA, Cosacak MI, Haston S, Ross SA, Williams R, Wong A, Abramowitz MK, Effiong A, Lee S, Abid MB, Agarabi C, Alaux C, Albrecht DR, Atkins GJ, Beck CR, Bonvin AMJJ, Bourke E, Brand T, Braun RJ, Bull JA, Cardoso P, Carter Dclose, 2019, Large expert-curated database for benchmarking document similarity detection in biomedical literature search, Database: the journal of biological databases and curation, Vol: 2019, Pages: 1-66, ISSN: 1758-0463 Croft RA, Dubois MAJ, Boddy AJ, Denis C, Lazaridou A, Voisin-Chiret AS, Bureau R, Choi C, Mousseau JJ, Bull JAclose, 2019, Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2 Coupling of Medicinally Relevant Fragments, European Journal of Organic Chemistry, Vol: 2019, Pages: 5385-5395, ISSN: 1434-193X Antermite D, Bull JA, 2019, Transition Metal-Catalyzed Directed C(sp(3))-H Functionalization of Saturated Heterocycles, SYNTHESIS-STUTTGART, Vol: 51, Pages: 3171-3204, ISSN: 0039-7881