Prof. Wei Tao is the Farokhzad Family Distinguished Chair for Innovation (Endowed Chair), Co-Director of Nano Immune-Imaging Core, Principal Investigator in the Center for Nanomedicine, and Faculty Member in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women’s Hospital (BWH), Harvard Medical School (HMS). He is also the first Distinguished Chair professor as an assistant professor in the history of his institution. He has been continuously named a Clarivate’s Global Highly Cited Researcher since 2021, and has published over 160 peer-reviewed, high-impact papers in prestigious journals such as Nature Medicine, Nature Nanotechnology, Science Translational Medicine, Nature Biomedical Engineering, Nature Reviews Materials, Nature Reviews Cancer, Nature Reviews Cardiology, Nature Reviews Methods Primers, PNAS, Nature Protocols, Nature Communications, Science Advances, Chemical Reviews, Chemical Society Reviews, Accounts of Chemical Research, Journal of the American Chemical Society, Angewandte Chemie, Advanced Materials, Materials Today, Matter (Cell Press), Med (Cell Press), etc. He has received multiple awards/grants including the American Heart Association (AHA) Transformational Project Award, American Lung Association (ALA) Courtney Cox Cole Lung Cancer Research Award, AHA Collaborative Sciences Award, ALA Cancer Discovery Award, LEO Foundation Research Grant, Novo Nordisk ValidatioNN Award, American Society of Transplantation (AST) Career Transition Grant (Translational Science), Harvard Catalyst - Cores Facility Program, Harvard/Brigham Health Technology Innovator Award, Distinguished Chair Professorship Foundation, Anaesthesia Department Basic Scientist Grant, Khoury Innovation Award, Center for Nanomedicine Research Fund, Nanotechnology Foundation, Stepping Strong Breakthrough Innovator Award, AHA's Second Century Early Faculty Independence Award, U.S. METAvivor Early Career Investigator Award, MIT Technology Review Top Chinese Innovators Under 35 (2020 TR35), World's Top 2% Scientist (Year-List since 2019; Career-List since 2023), Chemical Society Reviews (IF~40) Emerging Investigator Award, Advanced Materials (IF~27) Rising Star, Materials Today (IF~21) Rising Star Award, Angewandte Chemie (IF~16) Most Outstanding Referees Award, Materials Horizons (IF~12) Top 10 Outstanding Reviewers Award, etc. He is an elected Fellow of the International Association of Advanced Materials (FIAAM).

Biomaterials, RNA Medicine, Drug Delivery, Biomedical Engineering, Nanomedicine. Delivery of Nucleic Acids (mRNA, siRNA, etc.) for Next-Generation Medicine "Living Materials" (Engineered Cells, Microbes, Microalgae, etc.) for Medical Applications Synthetic Materials (Nanoparticles, Nanosheets, Hydrogels, etc.) for Therapy and Detection

Yaremenko A, Khan M, Zhen X, Tang Y, Tao W*. Clinical advances of mRNA vaccines for cancer immunotherapy. Med (Cell Press) 2024, in press. Zhou Z, Chen W, Cao Y, Abdi R, Tao W*. Nanomedicine-based strategies for the treatment of vein graft disease. Nature Reviews Cardiology 2024, doi: 10.1038/s41569-024-01094-y. He Z, Chen W, Hu K, Luo Y, Zeng W, He X, Li T, Ouyang J, Li Y, Xie L, Zhang Y, Xu Q, Yang S, Guo M, Zou W, Li Y, Huang L, Chen L, Zhang X, Saiding Q, Wang R, Zhang M, Kong N, Xie T, Song X, Tao W*. Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment. Nature Nanotechnology 2024, 19(9): 1386-1398. Xian J, Xiao F, Zou J, Luo W, Han S, Liu Z, Chen Y, Zhu Q, Li M, Yu C, Saiding Q, Tao W*, Kong N, Xie T. Elemene Hydrogel Modulating Tumor Immune Microenvironment for Enhanced Treatment of Postoperative Cancer Recurrence and Metastases. Journal of the American Chemical Society 2024, doi: 10.1021/jacs.4c12531. Li Y, Chen W, Koo S, Liu H, Saiding Q, Xie A, Kong N, Cao Y, Abdi R, Serhan CN, Tao W*. Innate immunity-modulating nanobiomaterials for controlling inflammation. Matter (Cell Press) 2024, 7(11): 3811-3844. Xiao Y, Tang Z, Zhang J, Saiding Q, Li Y, Du J, Tao W*. One-Pot Synthesis of Fe-Norepinephrine Nanoparticles for Synergetic Thermal-Enhanced Chemodynamic Therapy. Nano Letters 2024, 24(43): 13825-13833. Zhen X, Li Y, Yuan W, Zhang T, Li M, Huang J, Kong N, Xie X, Wang S, Tao W*. Biointerface-Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment. Advanced Materials 2024, 36(41): e2401495. Zhang Z, Shi S, Jin K, Huang W, Zhao J, Zhang Y, Wang J, Koo S, Tao W*, Chen T. MoSe2-based magnetic nanosystem for clinical enrichment, retrieval and elimination of circulating tumor cells. Nano Today 2024, 57: 102330. Shi Y, Zhen X, Zhang Y, Li Y, Koo S, Saiding Q, Kong N, Liu G, Chen W, Tao W*. Chemically Modified Platforms for Better RNA Therapeutics. Chemical Reviews 2024, 124(3): 929–1033. (Invited Article; Web of Science Highly Cited Paper) Tao N, Chen S, Mahdinloo S, Zhang Q, Lan T, Saiding Q, Chen S, Xiong Y, Tao W*, Ouyang J. A pH-responsive single-atom nanozyme for photothermal-augmented nanocatalytic tumor therapy. Nano Today 2024, 57, 102371. Zheng B, Li M, Zhang T, Li B, Li Q, Saiding Q, Chen W, Guo M, Koo S, Ji X, Tao W*. Functional modification of gut bacteria for disease diagnosis and treatment. Med (Cell Press) 2024, 5(8): 863-885. Ding Q, Li Y, Xu X, Li B, Saiding Q, Gu M, Tao W*, Tang BZ, Kim JS. Diverse Interactions between AIEgens and Biomolecules/Organisms: Advancing from Strategic Design to Precision Theranostics. Chem (Cell Press) 2024, 10(7): 2031-2073. Zhang Y, Shi Y, Khan M, Xiao F, Chen W, Tao W*, Yao K, Kong N. Ocular RNA nanomedicine: engineered delivery nanoplatforms in treating eye diseases. Trends in Biotechnology (Cell Press) 2024, 42(11): 1439-1452. Deng B, Liu S, Wang Y, Ali B, Kong N, Xie T, Koo S, Ouyang J, Tao W*. Oral Nanomedicine: Challenges and Opportunities. Advanced Materials 2024, 36(6): 2306081. Wu Y, Li X, Fu X, Huang X, Zhang S, Zhao N, Ma X, Saiding Q, Yang M, Tao W*, Zhou X, Huang J. Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases. Advanced Science 2024, 11(32): 2403399. Yang Y, Liang X, Saiding Q, Lin J, Li J, Wang W, Huang P, Huang L, Zeng W, Huang J, Chen H, Tao W*, Zeng X. Light-activated polymeric crosslinked nanocarriers as a checkpoint blockade immunoregulatory platform for synergistic tumor therapy. Materials Today 2024, 80: 1-22. Saiding Q, Qin D, An S, Patel D, Khan M, Kong N, Tao W*. Therapeutic nucleic acids in regenerative medicine and tissue repair. Nano Research 2024, 17: 8942-8976. Li Y, Chen W, Kang Y, Zhen X, Zhou Z, Liu C, Chen S, Huang X, Liu H, Koo S, Kong N, Ji X, Xie T, Tao W*. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nature Communications 2023, 14: 6973. Tang Z, You X, Xiao Y, Chen W, Li Y, Huang X, Liu H, Xiao F, Liu C, Koo S, Kong N, Tao W*. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. Proceedings of the National Academy of Sciences USA 2023, 120(44): e2304966120 . Saiding Q, Zhang Z, Chen S, Xiao F, Chen Y, Li Y, Zhen X, Khan M, Chen W, Koo S, Kong N, Tao W*. Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery. Advanced Drug Delivery Reviews 2023, 203: 115116. Chen S, Huang X, Xue Y, Álvarez-Benedi E, Shi Y, Chen W, Koo S, Siegwart D, Dong Y, Tao W*. Nanotechnology-based mRNA vaccines. Nature Reviews Methods Primers 2023, 3: 63. Liu C, Shi Q, Huang X, Koo S, Kong N, Tao W*. mRNA-based cancer therapeutics. Nature Reviews Cancer 2023, 23(8): 526-543. Zhang X, Wang T, Zhang Z, Liu H, Li L, Wang A, Ouyang J, Xie T, Zhang L, Xue J, Tao W*. Electrical Stimulation System Based on Electroactive Biomaterials for Bone Tissue Engineering. Materials Today 2023, 68: 177-203. Ouyang J, Deng B, Zou B, Li Y, Bu Q, Tian Y, Chen M, Chen W, Kong N, Chen T, Tao W*. Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota. Journal of the American Chemical Society 2023, 145(22): 12193–12205. Huang X, Li L, Chen Z, Yu H, You X, Kong N, Tao W*, Zhou X, Huang J. Nanomedicine for the Detection and Treatment of Ocular Bacterial Infections. Advanced Materials 2023, 35(46): 2302431. Yu L, Yu M, Chen W, Sun S, Huang W, Wang T, Peng Z, Luo Z, Fang Y, Li Y, Deng Y, Wu M, Tao W*. In situ separable nanovaccines with stealthy bioadhesive capability for durable cancer immunotherapy. Journal of the American Chemical Society 2023, 145(15): 8375–8388. Ma S, Kim J, Chen W, Li L, Lee J, Xue J, Liu Y, Chen G, Tang B, Tao W*, Kim J. Cancer CellSpecific Fluorescent Prodrug Delivery Platforms. Advanced Science 2023, 10(16): 2207768. Liu H, Chen W, Wu G, Zhou J, Liu C, Tang Z, Huang X, Gao J, Xiao Y, Kong N, Joshi N, Cao Y, Abdi R, Tao W*. Glutathione-scavenging nanoparticle-mediated PROTACs delivery for targeted protein degradation and amplified antitumor effects. Advanced Science 2023, 10(16): 2207439. Zhang X, Li Q, Li L, Ouyang J, Wang T, Chen J, Hu X, Ao Y, Qin D, Zhang L, Xue J, Cheng J, Tao W*. Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration. ACS Nano 2023, 17(7): 6466–6479. Mao Z, Rha H, Kim J, You X, Zhang F, Tao W*, Kim J. THQ–Xanthene: An Emerging Strategy to Create NextGeneration NIRI/II Fluorophores. Advanced Science 2023, 10(18): 2301177. Ouyang J, Zhang Z, Deng B, Liu J, Wang L, Liu H, Koo S, Chen S, Li Y, Yaremenko AV , Huang X, Chen W, Lee Y, Tao W*. Oral drug delivery platforms for biomedical applications. Materials Today 2023, 62: 296-326. Zhang F, Kang Y, Feng L, Xi G, Chen W, Kong N, Tao W*, Luan T, Koo S, Ji X. Infected wound repair with an ultrasound-enhanced nanozyme hydrogel scaffold. Materials Horizons 2023, 10(12): 5474-5483. (Invited Article; Front Cover Paper; Materials Horizons 10th Anniversary Collection) Zhang P, Xiao Y, Sun X, Lin X, Koo S, Yaremenko AV, Qin D, Kong N, Farokhzad OC, Tao W*. Cancer Nanomedicine Towards Clinical Translation: Obstacles, Opportunities, and Future Prospects. Med (Cell Press) 2023, 4(3): 147-167. Nie Y, Chen W, Kang Y, Yuan X, Li Y, Zhou J, Tao W*, Ji X. Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy. Biomaterials 2023, 295:122031. Chen Y, Qin D, Zou J, Li X, Guo X, Tang Y, Liu C, Chen W, Kong N, Zhang C, Tao W*. Living Leukocyte-Based Drug Delivery Systems. Advanced Materials 2023, 35(17): 2207787. Chen W, Li Y, Liu C, Kang Y, Qin D, Chen S, Zhou J, Liu H, Ferdows BE, Patel DN, Huang X, Koo S, Kong N, Ji X, Cao Y, Tao W*, Xie T. In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy. Angewandte Chemie International Edition 2023, 62(41): e202308413. Yi Y, Feng C, Yu M, Mei L, Wu M, Tao W*. Peptide-based siRNA delivery system for tumor vascular normalization and gene silencing in 4T1 cells. STAR Protocols (Cell Press) 2023, 4(1): 102138. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W*. The landscape of mRNA nanomedicine. Nature Medicine 2022, 28(11): 2273–2287. Huang X, Kon E, Han X, Zhang X, Kong N, Mitchell M, Peer D, Tao W*. Nanotechnology-based strategies against SARS-CoV-2 variants. Nature Nanotechnology 2022, 17(10): 1027–1037. Wang D, Feng C, Xiao Z, Huang C, Chen Z, Fang W, Ma X, Wang X, Luo L, Hu K, Tao W*. Therapeutic hydrogel for enhanced immunotherapy: A powerful combination of MnO2 nanosheets and vascular disruption. Nano Today 2022, 47: 101673. Kang Y, Zhang H, Chen L, Dong J, Yao B, Yuan X, Qin D, Yaremenko A, Liu C, Feng C, Ji X, Tao W*. The marriage of Xenes and Hydrogels: Fundamentals, Applications, and Outlook. The Innovation (Cell Press) 2022, 3(6): 100327. Ouyang J, Chen W, Tao W*. Design of application-optimized hydrogels based on a swollen polymer network model. Matter (Cell Press) 2022, 5(8): 2471-2473. Yi Y, Yu M, Feng C, Hao H, Zeng W, Lin C, Chen H, Lv F, Zhu D, Ji X, Mei L, Wu M, Tao W*. Transforming "Cold" Tumors into "Hot" Ones via Tumor Microenvironment-Responsive siRNA Micelleplexes for Enhanced Immunotherapy. Matter (Cell Press) 2022, 5(7): 2285-2305. Ouyang J, Xie A, Zhou J, Liu R, Wang L, Liu H, Kong N, Tao W*. Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Chemical Society Reviews 2022, 51(12): 4996–5041. Xiao Y, Tang Z, Huang X, Chen W, Zhou J, Liu H, Liu C, Kong N, Tao W*. Emerging mRNA technologies: Delivery strategies and biomedical applications. Chemical Society Reviews 2022, 51(10): 3828-3845. Kong N, Zhang R, Wu G, Sui X, Wang J, Kim NY, Blake S, De D, Xie T, Cao Y, Tao W*. Intravesical Delivery of KDM6A-mRNA via Mucoadhesive Nanoparticles Inhibits the Metastasis of Bladder Cancer. Proceedings of the National Academy of Sciences USA 2022, 119(7): e2112696119 Tao W*, Peppas NA. Robotic pills for gastrointestinal-tract-targeted oral mRNA delivery. Matter (Cell Press) 2022, 5(3): 775-777. Zhang Z, Zhou J, Liu C, Zhang J, Shibata Y, Kong N, Corbo C, Harris MB, Tao W*. Emerging Biomimetic Nanotechnology in Orthopedic Diseases: Progress, Challenges, and Opportunities. Trends in Chemistry (Cell Press) 2022, 4(5): 420-436. Chen W, Tao W*. Precise Control of the Structure of Synthetic Hydrogel Networks for Precision Medicine Applications. Matter (Cell Press) 2022, 5(1): 18-19. Huang X, Liu C, Kong N, Xiao Y, Yurdagul A, Tabas I, Tao W*. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols 2022, 17(3): 748–780. Chen W, Schilperoort M, Cao Y, Shi J, Tabas I, Tao W*. Macrophage-Targeted Nanomedicine for Diagnosis and Treatment of Atherosclerosis. Nature Reviews Cardiology 2022, 19(4): 228–249. Zhao M, Mi D, Ferdows BE, Li Y, Wang R, Li J, Patel D, Kong N, Shi S, Tao W*. State-of-the-art nanotechnologies for the detection, recovery, analysis and elimination of liquid biopsy components in cancer. Nano Today 2022, 42: 101361. Ji X, Tang Z, Liu H, Kang Y, Chen L, Dong J, Chen W, Kong N, Tao W*, Xie T. Nanoheterojunction-mediated thermoelectric strategy for cancer surgical adjuvant treatment and β-elemene combination therapy. Advanced Materials 2023, 35(8): 2207391. Ouyang J, Rao S, Liu R, Wang L, Chen W, Tao W*, Kong N. 2D Materials-based Nanomedicine: From Discovery to Applications. Advanced Drug Delivery Reviews 2022, 185: 114268. Zhang D, Zhong D, Ouyang J, He J, Qi Y, Chen W, Zhang X, Tao W*, Zhou M. Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy. Nature Communications 2022, 13: 1413. Jangili P, Kong N, Kim JH, Zhou J, Liu H, Zhang X, Tao W*, Kim JS. DNA-Damage-Response-Targeting Mitochondria-Activated Multifunctional Prodrug Strategy for Self-defensive Tumor Therapy. Angewandte Chemie International Edition 2022, 61(16): e202117075. Huang X, Wu G, Liu C, Hua X, Tang Z, Xiao Y, Chen W, Zhou J, Kong N, Huang P, Shi J, Tao W*. Intercalation-driven Formation of siRNA Nanogels for Cancer Therapy. Nano Letters 2021, 21(22): 9706-9714. Zhong D, Zhang D, Chen W, He J, Ren C, Zhang X, Kong N, Tao W*, Zhou M. Orally Deliverable Strategy Based on Microalgal Biomass for Intestinal Diseases Treatment. Science Advances 2021, 7(48): eabi9265. (Front Cover Paper; Web of Science Highly Cited Paper) Highlighted: Nature Medicine 2022, 28(6): 1100-1102. Zhao H, Xu J, Feng C, Ren J, Bao L, Zhao Y, Tao W*, Zhao Y, Yang X. Tailoring Aggregation Extent of Photosensitizer to Boost Phototherapy Potency for Eliciting Systemic Antitumor Immunity. Advanced Materials 2022, 34(8): e2106390. Singh N, Son S, An J, Kim I, Choi M, Kong N, Tao W*, Kim JS. Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics. Chemical Society Reviews 2021, 50(23): 12883-12896. Zhou J, Zhang Z, Joseph J, Zhang X, Ferdows BE, Patel DN, Chen W, Banfi G, Molinaro R, Cosco D, Kong N, Joshi N, Farokhzad OC, Corbo C, Tao W*. Biomaterials and Nanomedicine for Bone Regeneration: Progress and Future Prospects. Exploration 2021, 1(2): 20210011. Li S, Wang L, Gu Y, Lin L, Zhang M, Jin M, Mao C, Zhou J, Zhang W, Huang X, Corbo C, Tao W*, Lu E, Liu J. Biomimetic immunomodulation by crosstalk with nanoparticulate regulatory T cells. Matter (Cell Press) 2021, 4(11): 3621-3645. Tao W*, Farokhzad OC. Theranostic Nanomedicine in the NIR-II Window: Classification, Fabrication, and Biomedical Applications. Chemical Reviews 2022, 122(6): 5405-5407. Xiao Y, Tang Z, Huang X, Joseph J, Chen W, Liu C, Zhou J, Kong N, Joshi N, Du J, Tao W*. Glucose-responsive oral insulin delivery platform for one-treatment-a-day in diabetes. Matter (Cell Press) 2021, 4(10): 3269–3285. Highlighted: Matter, 2021, 4(12): 3790-3791. Kong N, Zhang H, Feng C, Liu C, Xiao Y, Zhang X, Mei L, Kim JS, Tao W*, Ji X. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nature Communications 2021, 12: 4777. Zhang X, Li L, Ouyang J, Zhang L, Xue J, Zhang H, Tao W*. Electroactive electrospun nanofibers for tissue engineering. Nano Today 2021, 39: 101196. Zhang X, Koo S, Kim JH, Huang X, Kong N, Zhang L, Zhou J, Xue J, Harris MB, Tao W*, Kim JS. Nanoscale Materials-Based Platforms for the Treatment of Bone-Related Diseases. Matter (Cell Press) 2021, 4(9): 2727-2764. Liu C, Sun S, Feng Q, Wu G, Wu Y, Kong N, Yu Z, Yao J, Zhang X, Chen W, Tang Z, Xiao Y, Huang X, Lv A, Yao C, Cheng H, Wu A, Xie T, Tao W*. Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy. Advanced Materials 2021, 33(37): 2102054. Ouyang J, Feng C, Zhang X, Kong N, Tao W*. Black Phosphorus in Biomedical Applications: Evolutionary Journey from Monoelemental Materials to Composite Materials. Accounts of Materials Research 2021, 2(7): 489–500. (ACS Editors' Choice Featured; Front Cover Paper) Farokhzad N, Tao W*. Materials Chemistry-Enabled Platforms in Detecting Sexually Transmitted Infections: Progress towards Point-of-Care Tests. Trends in Chemistry (Cell Press) 2021, 3(7): 589-602. Zhang X, Duan X, Hu Y, Tang Z, Miao C, Tao W*, Wu J. One-step and facile synthesis of peptide-like poly(melphalan) nanodrug for cancer therapy. Nano Today 2021, 37:101098. Ji X, Ge L, Liu C, Tang Z, Xiao Y, Chen W, Lei Z, Gao W, Blake S, De D, Shi B, Zeng X, Kong N, Zhang X, Tao W*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics. Nature Communications 2021, 12: 1124. Liu C, Shin J, Son S, Choe Y, Farokhzad N, Tang Z, Xiao Y, Kong N, Xie T, Kim JS, Tao W*. Pnictogens in Medicinal Chemistry: Evolution from Erstwhile Drugs to Emerging Layered Photonic Nanomedicine. Chemical Society Reviews 2021, 50(4): 2260-2279. Chen W, Liu C, Ji X, Joseph J, Tang Z, Ouyang J, Xiao Y, Kong N, Joshi N, Farokhzad OC, Tao W*, Xie T. Stanene-Based Nanosheets for ß-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy. Angewandte Chemie International Edition 2021, 60(13): 7155-7164. Yang J, Zhang X, Liu C, Wang Z, Deng L, Feng C, Tao W*, Xu X, Cui W. Biologically Modified Nanoparticles as Theranostic Bionanomaterials. Progress in Materials Science 2021, 118: 100768. Tang Z, Zhang X, Shu Y, Guo M, Zhang H, Tao W*. Insights from nanotechnology in COVID-19 treatment. Nano Today 2021, 36:101019. Liu Y, Wang J, Xiong Q, Hornburg D, Tao W*, Farokhzad OC. Nano-Bio Interactions in Cancer: from Therapeutics Delivery to Early Detection. Accounts of Chemical Research 2021, 54(2): 291–301.