Structural Biology and Protein structure-function Structure-based rational Drug Design Protein X-ray Crystallography and Molecular Modelling Biochemistry and structure of Carbohydrate Recognising Proteins Glycovirology, Glycoscience

BUM-ERDENE, K; LEFFLER, H; NILSSON, UJ; BLANCHARD, H* (2016) Structural characterisation of human galectin-4 N-terminal carbohydrate-recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose. Scientific Reports doi:10.1038/srep20289 http://www.nature.com/articles/srep20289 BOHLMANN, L; TREDWELL, GD; YU, X; CHANG, C-W; HASELHORST, H; WINGER, M; DYASON, JC; THOMSON, RJ; TIRALONGO, J; BEACHAM, IR*, BLANCHARD, H* & VON ITZSTEIN, M* (2015). Functional and structural characterisation of a heparanase. Nature Chemical Biology Dec; 11(12):955-7 YU, X; MISHRA, R; HOLLOWAY, G; VON ITZSTEIN, M; COULSON, BS AND BLANCHARD, H* (2015) Substantial receptor-induced structural rearrangement of rotavirus VP8*: potential implications for cross-species infection. ChemBioChem Oct; 16(15):2176-81 BUM-ERDENE, K; LEFFLER, H; NILSSON, UJ AND BLANCHARD, H*. (2015) Structural characterisation of human galectin-4 C-terminal domain –elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens. FEBS Journal Sep;282(17):3348-67 COLLINS, PM; BUM-ERDENE, K; YU, X and BLANCHARD, H* (2014) Galectin-3 interactions with glycosphingolipids. Journal of Molecular Biology Apr 3; 426(7) , p1439-1451 BUM-ERDENE, K; GAGARINOV, IA; COLLINS, PM; WINGER, M; PEARSON, AG; WILSON, JC; LEFFLER, H; NILSSON, UJ; GRICE, ID; AND BLANCHARD, H.* (2013) Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3 specific inhibitors. ChemBioChem (2013) 14, 1331-1342 YU, X; DANG, VT; FLEMING, FE; VON ITZSTEIN, M; COULSON, BS AND BLANCHARD H* (2012). Structural basis of rotavirus strain preference towards N-acetyl or N-glycolylneuraminic Acid-containing receptors. J. Virol. (2012) Dec 86(24):13456-66.