BS, Illinois Institute of Technology, 1966 AM, Harvard University, 1967 PhD, Harvard University, 1970

Molecules of Biological Interest, Applications of Stereopopulation Control

Synthetic efforts have included the preparation of stable tryptophan derivatives with tetrahedral geometry at C-3 that are mirror-image inhibitors of tryptophan synthesizing and degrading enzymes and aldose reductase. Our group has devised and is exploiting a regiospecific route to alkylated imidazoles, histamines and histidines, found to possess antimalarial activity. The thrust of the program on stereopopulation control has been to demonstrate the utility of conformational restriction, including the development of a novel method for drug delivery that allows a modulation in the timing of drug release, and creation of a system whereby van der Waals substituent volumes can be determined using spectroscopic methodologies.

A Semiconductive Coordination Network Based on 2,3,6,7,10,11-Hexakis(methylthio)triphenylene and BiCl 3

Synthesis of Novel Ring-Substituted Histidines and Histamines

Regiospecific Alkylation of Histidine and Histamine at C-2

Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6-diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors

Stereopopulation Control. 7. Rate Enhancement in the Lactonization of 3-(o-Hydroxyphenyl)propionic Acids: Dependence on the Size of Aromatic Ring Substituents

Sapphyrins: Novel Aromatic Pentapyrrolic Macrocycles