My research interests are in the broadly defined fields of chemical biology and medicinal chemistry. My research team uses rational synthetic and combinatorial chemistry approaches to synthesize and elucidate structure-activity relationship of novel cyclic peptides as biological probes or lead compounds for drug discovery. Our research has implications for treatment of multi-drug resistant bacterial infections and treatment of central nervous system diseases.

Bionda N, Fleeman RM, de la Fuente-Núñez C, Rodriguez MC, Reffuveille F, Shaw LN, Pastar I, Davis SC, Hancock RE, Cudic P. Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities. Eur. J. Med. Chem. 108 (2016) 3543-63. PubMed PMID: 26703794. Cudic P, Joshi N, Sagher D, Williams BT, Stawikowski MJ, Weissbach H. Identification of activators of methionine sulfoxide reductases A and B. Biochem. Biophys. Res. Commun. 469 (2016) 863-786. PubMed PMID: 26718410. Jakas A, Perc M, Suc J, Rodriguez MC, Cudic M, Cudic P. Synthesis of anthrose lipidic derivative as mimic of B. anthracis BclA glycoprotein for use in ELISA-like binding assays. J. Carbohydr. Chem. 35 (2016) 69-85. http://dx.doi.org/10.1080/07328303.2016.1139124 Bionda N, Pastar I, Davis SC, Cudic P. In vitro and in vivo activities of novel cyclic lipopeptides against staphylococcal biofilms. Protein Pept. Lett. 21 (2014) 52-56. PubMed PMID: 24164269. Bionda N, Stawikowski M, Stawikowska R, Cudic M, López-Vallejo F, Treitl D, Medina-Franco J, Cudic P. Effects of cyclic lipodepsipeptide structural modulation on stability, antibacterial activity, and human cell toxicity. ChemMedChem. 7 (2012) 871-882. PubMed PMID: 22392790.