Education 1990 - 1994 Ohio State University, Columbus, Ohio, Ph. D. in Organic Chemistry Supervisor: Dr. Anthony W. Czarnik 1983 - 1987 Seoul National University, Korea, B. S. in Industrial Chemistry Professional Experience 2014 - Present Distinguished Professor, Department of Chemistry Nano Science, Ewha Womans University 2009 - Present Professor, Department of Chemistry Nano Science, Ewha Womans University 2002 - 2009 Assistant/Associate Professor, Department of Chemistry Nano Science,Ewha Womans University 1998 - 2002 Assistant Professor of Department of Chemistry, Silla University 1996 - 1998 Post-Doctoral Fellow, Department of Chemistry, The Scripps Research Institute, La Jolla, CA (Professor Kim D. Janda) 1994 - 1996 Post-Doctoral Fellow, Department of Chemistry, UCLA (Professor Doanld J. Cram)

Photodynamic Therapy(PDT) and Theranostics Fluorescent Imaging Probes & Chemosensors Polydiacetylenes (PDAs)

Fluorescent chemosensors facilitate the visualization of plant health and their living environment in the sustainable agriculture Yang-Yang Gao, Jie He, Xiao-Hong Li, Jian-Hong Li, Hong Wu, Ting Wen, Jun Li*, Ge-Fei Hao*, Juyoung Yoon* Chem. Soc. Rev. 2024 Remote Control of Energy Transformation-Based Cancer Imaging and Therapy Hai Xu, Dahee Kim, Yuan-Yuan Zhao, Chowon Kim, Guosheng Song,* Qiongzheng Hu,* Heemin Kang,* Juyoung Yoon*. Adv. Mater. 2024 , 2402806 Development of a Hydrogen Peroxide Fluorescent Probe for the Rapid Discrimination of IDH1 Mutant Gliomas from the Wild-type Mingxiu Wang, Haoran Wang, Heqian Zhao, Guixin Qin, Lixin Ma,* Qingling Xu,* Juyoung Yoon* Sensor Actuat. B-Chem 2024 , 412 , 135850 Insight into mercury ion detection in environmental samples and imaging in living systems by a near-infrared fluorescent probe Shujing Fang, Liangwei Zhang,*, Yang Zhao, Xia Zhang, Li Zhang, Lingxin Chen,*, Juyoung Yoon,*, Shudi Liu* Sensor Actuat. B-Chem. 2024 , 411 , 135768 Screening drug-induced liver injury through two independent parameters of lipid droplets and peroxynitrite with a π-extended coumarin-based NIR fluorescent probe Bo Zhao, Shuo Zheng, Qingqing Liu, Chao Dong, Baoli Dong*, Chunhua Fan*, Zhengliang Lu,* Juyoung Yoon* Sensor Actuat. B-Chem 2024 , 410, 135659 Charge Transfer-promoted Excited State of Heavy-atom-free Photosensitizer for Efficient Application of Mitochondria-targeted Fluorescence Imaging and Hypoxia Photodynamic Therapy Thanh Chung Pham, Moonyeon Cho, Van-Nghia Nguyen, Van Nguyen, Gyoungmi Kim, Seongman Lee, Wim Dehaen, Juyoung Yoon,* Songyi Lee* ACS Appl. Mater. Inter. 2024 , 16(17) , 21699–21708 Supramolecular phthalocyanine assemblies-enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging Yuan-Yuan Zhao, Xiaojun Zhang, Zixuan Chen, Yihui Xu, Heejeong Kim, Hyunsun Jeong, You Rim Lee, Jiah Lee, Xingshu Li,* Juyoung Yoon* Aggregate 2024 , 5 , e514 Preparations of MgO Nanoparticles by Poly(acrylic acid)s Template-Assisted Method and Photovoltaic Performances of Dye-Sensitized Solar Cells based on MgO lnterlayer Mi-Ra Kim, Seongman Lee, Juyoung Yoon,* Songyi Lee* ACS Appl. Mater. Inter. 2024 , 16(16) , 19957-19967 An ER-targeted, Viscosity-sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway Shuang Zeng, Yang Wang, Chen Chen, Heejeong Kim, Xiaosheng Liu, Maojun Jiang, Yichu Yu, Yves S. Kafuti, Qixian Chen, Jingyun Wang*, Xiaojun Peng, Haidong Li*, Juyoung Yoon* Angew. Chem. Int. Ed. 2024 , 63(9) , e202316487 Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy Jing-Jing Hu, Lizhen Yuan, Yunfan Zhang, Jing Kuang, Wen Song, Xiaoding Lou,* Fan Xia, Juyoung Yoon* Angew. Chem. Int. Ed. 2024 , 63(9) , e202317578 Recent advances and challenges in monitoring chromium ions using fluorescent probes Shudi Liu, Liangwei Zhang*, Heejeong Kim, Jinyu Sun, Juyoung Yoon* Coord. Chem. Rev. 2024 , 501 , 215575 Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy Yuan-Yuan Zhao, Heejeong Kim, Van-Nghia Nguyen, Sunbok Jang*, Won Jun Jang*, Juyoung Yoon* Coord. Chem. Rev. 2024 , 501 , 215560 Activatable Near-infrared Versatile Fluorescent and Chemiluminescent Dyes based on Dicyanomethylene-4H-pyran Scaffold: From Design to Imaging and Theranostics Haidong Li, Jingyun Wang, Heejeong Kim, Xiaojun Peng,* Juyoung Yoon* Angew. Chem. Int. Ed. 2024 , 63(6) , e202311764 A class of the activatable NIR-II photoacoustic dyes Jiangfeng Li, Jiangyan Wang, Lizhen Xu, Hanwen Chi, Xing Liang, Juyoung Yoon* Angew. Chem. Int. Ed. 2024 , 63(2) , e202312632 Recent advances in enzyme-activated NIR fluorescent probes for biological applications Hyunsun Jeong, Xiaofeng Wu,*, Jun-Seok Lee,* Juyoung Yoon,* Trends in Analytical Chemistry 2023 , 168 , 117335 Regulating 1 O2 generation from heavy-atom-free triplet photosensitizers based on thiophene-fused BODIPY Thanh Chung Pham, Moonyeon Cho, Van-Nghia Nguyen, Thuy Kieu Van Nguyen, Gyoungmi Kim, Suhong Min, Mi-Ra Kim, Juyoung Yoon, Songyi Lee* Dyes Pigm. 2023 , 219 , 111617 Self-Assembly Induced Photosensitization of Long-Tailed Heavy-Atom-Free BODIPY Derivatives for Photodynamic Therapy Jigai li, Xianfa Du, Xin Zhou,* Juyoung Yoon*. Adv. Healthc. Mater. 2023 , 12 Activatable nano-photosensitizers for precise photodynamic cancer therapy Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou*, Hong-Bo Cheng*, Juyoung Yoon* Coord. Chem. Rev. 2023 , 493 , 215324 Janus-Type ESIPT Chromophores with Distinctive Intramolecular Hydrogen-bonding Selectivity Yahui Chen, Sheng Lu, Syed Ali Abbas Abedi, Minseok Jeong, Haidong Li, Myung Hwa Kim, Sungnam Park,* Xiaogang Liu,* Juyoung Yoon,* Xiaoqiang Chen* Angew. Chem. Int. Ed. 2023 , 62(40) , e202311543 Fluorescent Dyes Based on Rhodamine Derivatives for Bioimaging and Therapeutics: Recent Progresses, Challenges, and Prospects Shuang Zeng, Xiaosheng Liu, Yves S. Kafuti, Heejeong Kim, Jingyun Wang,* Xiaojun Peng,* Haidong Li,* Juyoung Yoon* Chem. Soc. Rev. 2023 , 52 , 5607-5651 Recent progress of two- photon/NIR fluorescent probes for metal ions Yahui Chen, Shiyue Zheng, Myung Hwa Kim, Xiaoqiang Chen,* Juyoung Yoon* Curr. Opin. Chem. Biol. 2023 , 75 , 102321 An Efficient Green Approach to Constructing Adenine Sulfate-derived Multicolor Sulfur, Nitrogen Co-doped Carbon Dots and their Bioimaging Applications Dinh Khoi Dang, Van-Nghia Nguyen, Zeeshan Tahir, Hyunsun Jeong, Sungdo Kim, Hong Nhan Tran, Shinuk Cho, Yun Chang Park, Jong-Seong Bae, Chinh Tam Le*, Juyoung Yoon*, Yong Soo Kim,* ACS Appl. Mater. Inter. 2023 , 15(27) , 32783–32791 Photodynamic and photothermal therapies for bacterial infection treatment Heejeong Kim, You Rim Lee, Hyunsun Jeong, Jiah Lee, Xiaofeng Wu, Haidong Li, Juyoung Yoon* Smart Molecules 2023 , 1(1) , e20220010 Cancer Immunotherapy Elicited by Immunogenic Cell Death Based on Smart Nanomaterials Mengyao Yang, Cheng Zhang, Rui Wang, Xiaofeng Wu, Haidong Li*, Juyoung Yoon* Small Methods 2023 , 7(5) , 2201381 BODIPY as multifunctional theranostic reagent in biomedicine: Self-Assembly, properties and applications Hong-Bo Cheng,* Xiaoqiao Cao, Shuchun Zhang, Keyue Zhang, Yang Cheng, Jiaqi Wang, Jing Zhao, Liming Zhou, Xing-Jie Liang,* Juyoung Yoon*. Adv. Mater. 2023 , 35 ESIPT-Inspired Dual-Mode Photoswitches with Fast Molecular Isomerization in the Solid State Yahui Chen, You Rim Lee, Wenjing Wang, Yu Fang, Sheng Lu, Jingjing Han, Xiaoqiang Chen,* Myung Hwa Kim,* Juyoung Yoon* Angew. Chem. Int. Ed. 2023 , 62(15) , e202301765 Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway Xingshu Li, Jae Sang Oh, Yoonji Lee, Eun Chae Lee, Mengyao Yang, Nahyun Kwon, Tae Won Ha, Dong-Yong Hong, Yena Song, Hyun Kyu Kim, Byung Hoo Song, Sun Choi,*, Man Ryul Lee,* Juyoung Yoon,* Biomater. Res. 2023 , 27(23) , 236-255 Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy Van-Nghia Nguyen, Thuy Nguyen Thi Dao, Moonyeon Cho, Hyunsun Jeong, Minh-Tri Nguyen-Le, Yong Shin,* Juyoung Yoon,* Coord. Chem. Rev. 2023 , 479 , 215006 Recent progress on photodynamic therapy and photothermal therapy Heejeong Kim, Mengyao Yang, Nahyun Kwon, Moonyeon Cho, Jingjing Han, Rui Wang, Sujie Qi, Haidong Li, Van-Nghia Nguyen, Xingshu Li, Hong-Bo Cheng, Juyoung Yoon* Bull. Korean Chem. Soc. 2023 , 44(3) , 236-255 Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe Yves S. Kafuti, Shuang Zeng, Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon,* Haidong Li Chem. Commun. 2023 , 59(17) , 11438-11441 A Biocompatible Probe for the Detection of Neutrophil Elastase Free from the Interference of Structural Changes and Its Application to Ratiometric Photoacoustic Imaging In Vivo Ling Huang, Wanting Su, Lin Zhu, Jiangfeng Li, Wei Quan, Juyoung Yoon*, Weiying Lin* Angew. Chem. Int. Ed. 2023 , 62(9) , e202217508 Noncancerous disease-targeting AIEgens 30. Yanhong Duo,* Guanghong Luo,* Wentao Zhang, Renzhi Wang, Gary Guishan Xiao, Zihuang Li, Xianming Li, Meili Chen, Juyoung Yoon,* Ben Zhong Tang* Chem. Soc. Rev. 2023 , 52(3) , 1024-1067 Prospects of Coupled Iron-based Nanostructures in Preclinical Antibacterial Therapy Jingjing Han, Shuang Zeng, Yahui Chen, Haidong Li,* Juyoung Yoon*. Adv. Drug Del. Rev. 2023 , 193 , 114672 Recent Advances in the Optical Detection of Chemical Warfare Agents: A Legacy of the 21th Century Vinod Kumar,* Heejeong Kim, Bipin Pandey, Tony D. James,* Juyoung Yoon,* Eric V. Anslyn* Chem. Soc. Rev. 2023 , 52(2) , 663-704 Fluorescent probes for the detection of chemical warfare agents Wen-Qi Meng,* Adam C. Sedgwick, Nahyun Kwon, Mingxue Sun, Kai Xiao,* Xiao-Peng He,* Eric V. Anslyn,* Tony D James,* Juyoung Yoon* Chem. Soc. Rev. 2023 Controlled Supramolecular Self-Assembly Pathways by Intramolecular Rotation of D-A Molecular System Toward the Signal Differentiation Detection of Toxic Vapors Yongxian Guo, Yanjun Gong, Mei Zhao, Jiantao Ping, Juyoung Yoon*, Qiongzheng Hu* Small 2023 , 19(1) , 2205044 A Tyrosinase-activated Pt(II) Complex for Melanoma Photodynamic Therapy and Fluorescence Imaging Yifan Liu, Han Zhao, Li Li, Baoyin Yang, Yongli Yue, Meng Li, Xiaowei Shi, Bo Zhang, Lei Wang, Chaochao Qi, Yibing Liu, Shuguang Ren, Kai Zhang,* Juyoung Yoon* Sensor Actuat. B-Chem. 2023 , 374 , 132836 Mitochondria-Targeted Smart AIEgens: Imaging and Therapeutics Haidong Li,* Heejeong Kim, Cheng Zhang, Shuang Zeng, Qixian Chen, Lingyun Jia, Jingyun Wang,* Xiaojun Peng, Juyoung Yoon* Coord. Chem. Rev. 2022 , 473 , 214818 A J-aggregated Nanoporphyrin Overcoming Phototoxic Side Effects in Superior Phototherapy with Two-Pronged Effects Mengyao Yang, Xingshu Li,* Gyoungmi Kim, Rui Wang, Seong-Jin Hong Chang-Hee Lee,* Juyoung Yoon* Chem. Sci. 2022 , 13(43) , 12738-12746 Hexa-BODIPY-Cyclotriphosphazene Based Nanoparticle for NIR Fluorescence/Photoacoustic Dual-Modal Imaging and Photothermal Cancer Therapy Nahyun Kwon, Kwang H. Kim, Sinyoung Park, Yejin Cho, Eun-Yeong Park, Junha Lim, Seda Çetindere, Süreyya Oğuz Tümay, Won Jong Kim, Xingshu Li*, Ki Taek Nam*, Chulhong Kim*, Serkan Yeşilot,* Juyoung Yoon* Biosens. Bioelectron. 2022 , 216 , 114612 Polymetallic Hybrid Nanoplatform with Hyperthermia-Amplified Dual Enzyme-Like Activities for Efficient Speeded-Up Bacterially Infected Wound Healing Xiaojun He, Zaian Deng, Ji-Ting Hou, Xiaoshuai Sun, Danfeng Jiang, Nahyun Kwon, Lisong Ye, Enoch Obeng, Rongdang Hu, Yi Wang, Xingjie Zan,* Juyoung Yoon*, Jianliang Shen*. Adv. Mater. Interfaces 2022 , 2201422 Monitoring mitochondrial nitroreductase activity in tumors and hind limb ischemic mice model using a novel activatable NIR fluorescent probe Xiaosheng Liu, Shuang Zeng, Ming Zhang, Maojun Jiang, Yves S. Kafuti, Pingping Shangguan, Yichu Yu, Qixian Chen, Jingyun Wang,* Xiaojun Peng, Juyoung Yoon,* Haidong Li* Chem. Commun. 2022 , 58(81) , 11438-11441 Tumor Selective Metabolic Reprogramming as a Prospective PD-L1 Depression 2 Strategy to Reactivate Immunotherapy Yu Liu, Zaigang Zhou,* Jiting Hou, Wei Xiong, Heejeong Kim, Jiashe Chen, Chunjuan Zheng, Xin Jiang, Juyoung Yoon,*. Adv. Mater. 2022 , 34(41) , 2206121 Construction of Rhodamine-based AIE Photosensitizer Hydrogel with Clinical Potential for Selective Ablation of Drug-Resistant Gram-Positive Bacteria In Vivo Shuang Zeng, Zuokai Wang, Chen Chen, Xiaosheng Liu, Yu Wang, Qixian Chen, Jingyun Wang*, Haidong Li*, Xiaojun Peng, Juyoung Yoon*. Adv. Healthc. Mater. 2022 , 11(17) , 2200837 Rhodamine-thiourea linked naphthalimide derivative to image ATP in mitochondria using two channels You Rim Lee, Nahyun Kwon,* K.M. K. Swamy, Gyoungmi Kim, Juyoung Yoon* Chem.-Asian J. 2022 , 17(15) , e202200413 Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm Mengyao Yang, Zulal Özdemir, Heejeong Kim, Sanghee Nah, Erik Andris, Xingshu Li,* Zdeněk Wimmer,* Juyoung Yoon,*. Adv. Healthc. Mater. 2022 , 11(14) , 2200529 Rational Molecular Design of Efficient Heavy-Atom-Free Photosensitizers for Cancer Photodynamic Therapy Van-Nghia Nguyen, Jeongsun Ha, Hyunsun Jeong, Moonyeon Cho, Gyongmi Kim, Juyoung Yoon,* ChemPlusChem 2022 , 87(7) , e202200086 Albumin-mediated “Unlocking” of Supramolecular Prodrug-like Nanozymes Toward Selective Imaging-guided Phototherapy Jingjing Han, Haidong Li, Luyang Zhao, Gyoungmi Kim, Yahiu Chen, Xuehai Yan,* Juyoung Yoon* Chem. Sci. 2022 , 13(26) , 7814-7820 Structure-oriented design strategy to construct NIR AIEgens to selectively combat gram (+) multidrug-resistant bacteria in vivo Haidong Li, Mengyao Yang, Jiseon Kim, Jeongsun Ha, Jingjing Han, Heejeong Kim, Yejin Cho, Jingyun Wang, Ki Taek Nam,* Juyoung Yoon,* Biomaterials 2022 , 286 , 121580 Polydopamine, Harness of the Antibacterial Potentials-A Review Xiaojun He, Enoch Obeng, Xiaoshuai Sun, Nahyun Kwon, Jianliang Shen,* Juyoung Yoon* Materials Today Bio 2022 , 15 , 100329 Simultaneous Detection of Hypochlorite and Singlet Oxygen by a Thiocoumarin-Based Ratiometric Fluorescent Probe Moonyeon Cho, Van-Nghia Nguyen*, Juyoung Yoon,* ACS Measurement Science Au 2022 , 2(3) , 219-223 Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission Xiaoxie Ma, Yurou Huang, Syed Ali Abbas Abedi, Heejeong Kim, Tan Teck Boon Davin, Xiaogang Liu, Wen-Chao Yang, Yao Sun, Sheng Hua Liu, Jun Yin*, Juyoung Yoon,* Guang-Fu Yang,* CCS Chemistry 2022 , 4(6) , 1961-1976 Organic photosensitizers for antimicrobial phototherapy Van-Nghia Nguyen, Zheng Zhao, Ben Zhong Tang,* Juyoung Yoon* Chem. Soc. Rev. 2022 , 51(9) , 3324-3340 Future-Oriented Advanced Diarylethene Photoswitches: From Molecular Design to Spontaneous Assembly Systems Hong-Bo Cheng,* Shuchun Zhang, Enying Bai, Xiaoqiao Cao, Jiaqi Wang, Ji Qi, Jun Liu, Jing Zhao,* Liqun Zhang,* Juyoung Yoon,*. Adv. Mater. 2022 , 34(16) , 2108289 Fluorescent probes for the detection of disease-associated biomarkers Wei-Tao Dou, Hai-Hao Han, Adam C. Sedgwick, Guo-Biao Zhu, Yi Zang, Xin-Rong Yang*, Juyoung Yoon*, Tony D. James*, Jia Li*, Xiao-Peng He* Sci. Bull 2022 , 67(8) , 853-878 Reactivity Differences Enable ROS for Selective Ablation of Bacteria Xiaofeng Wu, Mengyao Yang, Ji Seon Kim, Rui Wang, Gyoungmi Kim, Jeongsun Ha, Heejeong Kim, Yejin Cho, Ki Taek Nam,* Juyoung Yoon* Angew. Chem. Int. Ed. 2022 , 61(17) , e202200808 Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment Jingjing Han, Haidong Li, Juyoung Yoon* Nano Today 2022 , 43 , 101392 Recent Progress on Small Molecule-based Fluorescent Imaging Probes for Hypochlorous Acid (HOCl)/Hypochlorite (OCl-) Nahyun Kwon, Yahui Chen, Xiaoqiang Chen,* Myung Hwa Kim,* Juyoung Yoon* Dyes Pigments 2022 , 200 , 110132 A coumarin-based reversible two-photon fluorescence probe for imaging glutathione near N-methyl-d-aspartate (NMDA) receptors Nahyun Kwon, Chang Su Lim, Dayoung Lee, Gyeongju Ko, Jeongsun Ha, Moonyeon Cho, K. M. K. Swamy, Eun-Young Lee, Dong Joon Lee, SangJip Nam, Xin Zhou,* Hwan Myung Kim,* Juyoung Yoon* Chem. Commun. 2022 , 58(22) , 3633-3636 A facile, protein-derived supramolecular theranostic strategy for multimodal-imaging-guided photodynamic and photothermal immunotherapy in vivo Hong-Bo Cheng,* Hao Dai, Xiaoqiong Tan, Hao Li, Huihui Liang, Chenyan Hu, Mingwei Huang, Jin Yong Lee, Jing Zhao,* Liming Zhou,* Yuguang Wang,* Liqun Zhang, Juyoung Yoon*. Adv. Mater. 2022 , 34(11) , 2109111