Degrees PhD (Chemistry), University of Florida (1999) MSc (Biotechnology), University of Teesside, UK (1995) BSc (Chemistry), Zurich University of Applied Sciences, Switzerland (1992) Postdoctoral Fellowship Postdoc at Penn State University, 1999-2002

Biophysical/Bioorganic

Courses CHEM 301: Biochemistry I CHEM 573: Biotechnology in Chemistry (grad)

Orru, R., Lutz S. (2015) EXPLORING MECHANISTIC CHANGES IN OLD YELLOW ENZYME BIOCATALYSIS UPON CIRCULAR PERMUTATION. submitted. Daugherty, A.B., Horton, J.R., Cheng, X., Lutz S. (2015) ACS Catalysis ASAP; CONSEQUENCES OF CIRCULAR PERMUTATION ON THE STRUCTURE AND ACTIVITY OF OLD YELLOW ENZYME. (DOI) Quertinmont, L.T., Orru, R., Lutz, S. (2015) Chem. Commun. 51: 122-124; RAPID PARALLEL PROTEIN EVALUATOR (RAPPER), FROM GENE TO ENZYME FUNCTION IN ONE DAY. (DOI) Muthu, P., Chen, H., Lutz S. (2014) ACS Chem. Biol. 9(10): 2326-2333; REDESIGNING HUMAN 2’-DEOXYCYTIDINE KINASE ENANTIOSELECTIVITY FOR L-NUCLEOSIDE ANALOGS AS REPORTERS IN POSITRON EMISSION TOMOGRAPHY. (DOI) Fischereder, E., Pressnitz, D., Kroutil, W., Lutz S. (2014) Bioorg. Med. Chem. 22: 5633-5637; ENGINEERING STRICTOSIDINE SYNTHASE: RATIONAL DESIGN OF A SMALL, FOCUSED CIRCULAR PERMUTATION LIBRARY OF THE β-PROPELLER FOLD ENZYME. (DOI) Lutz S., Daugherty, A.B., Yu, Y., Qian, Z. Generating random circular permutation libraries in Directed Evolution Library Creation, Methods of Molecular Biology, Humana Press, (2014). (DOI) Iamurri, S.A., Daugherty, A.B., Edmondson, D., Lutz S. (2013) Prot. Eng. Design & Selection 26: 791-795; truncated FAD synthetase for direct biocatalytic conversion of riboflavins and analogs to flavin mononucleotides. (DOI) Daugherty A.B.,Govindarajan, S., Lutz S. (2013) J. Am. Chem. Soc. 135(38) 14425-14432; Improved biocatalysts from a synthetic circular permutation library of the flavin-dependent oxidoreductase old yellow enzyme. (DOI) Hollfelder, F., Lutz, S. (2013) Curr. Opin. Struct. Biol. 23(4) 569-570; JUST (PROTEIN) ENGINEERING? (DOI) Daugherty A.B., Muthu, P., Lutz S. (2012) Biochemistry 51(41) 8247-8255; NOVEL PROTEASE INHIBITORS VIA COMPUTATIONAL REdesign of SUBTILISIN BPN’ propeptide. (DOI) Bornscheuer, U.T., Huisman, G., Kazlauskas, R.J., Lutz S., Moore, J., Robins, K. (2012) Nature 485:185-194; ENGINEERING THE THIRD WAVE OF BIOCATALYSIS. (DOI) Burai, T.N., Panay, A.J., Zhu, H., Lian, T., Lutz S. (2012) ACS Catalysis 2: 667-670; light driven, quantum dot-mediated regeneration of fmn to drive reduction of ketoisophorone by old yellow enzyme. (DOI) Laszlo, J.A., Yu Y., Lutz S. Compton, D.L. (2011) J. Mol. Catal. Enzym. B. 72(3-4) 175-180; GLYCEROL ACYL TRANSFER KINETICS OF A circular permutATED CANDIDA ANTARCTICA LIPASE B. (DOI) Yu Y., Lutz S. (2011) Trends Biotech. 29(1) 18-25; CIRCULAR PERMUTATION: A DIFFERENT WAY TO ENGINEER ENZYME STRUCTURE AND FUNCTION. (DOI) Liu L., Murphy P., Baker D., Lutz S. (2010) Chem. Commun. (Cambridge) 46 8803-8805; COMPUTATIONAL DESIGN OF AN ORTHOGONAL NUCLEOSIDE ANALOG KINASE. (DOI) Lutz S. (2010) Curr. Opin. Biotech. 21(6) 734-743; beyond directed evolution - semi-rational protein engineering and design. (DOI) Lutz S. (2010) Science 329(5989) 285-287; SCIENCE PERSPECTIVE: REengineering enzymes. (DOI / FullText / Reprints) Reitinger S., Yu Y., Wicki J., Ludwiczek M., D’Angelo I., Baturin S., Okon M., Strynadka N.C.J., Lutz S., Withers S.G., McIntosh L.P. (2010) Biochemistry 49(11) 2464-2474; Circular permutation of bacillus circulans xylanase: a kinetic and structural study. (DOI) Li Y., Soni P., Liu L., Zhang X., Liotta D., Lutz S. (2010) Bioorg. Med. Chem. Lett. 20(3) 841-843; SYNTHESIS OF FLUORESCENT NUCLEOSIDE ANALOGS AS PROBES FOR 2’-DEOXYRIBONUCLEOSIDE KINASES. (DOI) Yu Y., Lutz S. (2010) Biotech. Bioeng. 105(1) 44-50; improved triglyceride transesterification by circular permutated candida antarctica lipase b. (DOI)