2022-present: Asa Griggs Candler Professor of Chemistry, Emory University 2021-2022: University Faculty Scholar and Showalter Faculty Scholar, Purdue University 2020-2022: Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2018-2020: Associate Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2012-2018: Assistant Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2020-2022: Organic Division Head, Department of Chemistry, Purdue University 2020-2022: Program Co-Leader, the Purdue Center for Cancer Research 2020-2022: Equity Advisor, Department of Chemistry, Purdue University 2019-2022: Associate Director, the Purdue Drug Discovery NIH T32 Training Program Education and Training 1998-2002: B.S. Peking University, Advisor: Professors Zhen Yang and Jiahua Chen 2002-2004: Research Assistant, Peking University, Advisor: Professors Zhen Yang and Jiahua Chen 2004-2009: Ph.D. in Chemistry, Columbia University, Advisor: Professor Samuel J. Danishefsky 2009-2012: Postdoctoral Fellow, Advisor: Professor Stuart L. Schreiber, Harvard University and The Broad Institute

Total Synthesis via Catalytic Carbonylation Divergent Total Synthesis via Funtional Group Pairing Strategy Total Synthesis and Biological Study of Polycyclic Diterpenes (Hydroxy)Cyclopropanol Ring-Opening Chemistry Amphoteric Diamination to N- Heterocylces Medicinal Chemistry and Chemical Biology

Liu, C.; Zhang, M.; Zeng, L.; Wan, Y.*; M. Dai* “Ten-Step Total Synthesis of (+/-)-Phaeocaulisin A Enabled by Cyclopropanol Ring-Opening Carbonylation” J. Am. Chem. Soc. 2024, 146, asap. Cancer Immunology Zeng, L.; Zhu, Y.; Cui, X.; Chi, J.; Uddin, A.; Zhou, Z.; Song, X.; Dai, M.; Cristofanilli, M.; Kalinsky, K.; Wan, Y.* “Tuning immune-cold tumor by suppressing USP10/B7-H4 proteolytic axis reinvigorates therapeutic efficacy of ADCs” Advanced Science, 2024, 11, 2400757. Methodology de Andrade Horn, P.;† Collins, M. J. E.;† Fresh, A. A.; Dai, M.* “Divergent Synthesis of delta-Valerolactones and Furanones via Palladium or Copper-Catalyzed alpha-Hydroxycyclopropanol Ring Opening Cyclizations” Chem. Commun. 2024, 60, 10112-10115 Xu, B.†.; Zhang, Z.†.; Tantillo, D. J.;* Dai, M.* "Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement"J. Am. Chem. Soc. 2024, 146, 21250-21256. Ma, D.; Duran, P.; Al-Ahmad, R.; Hestehave, S.; Joa, M.; Alsbiei, O.; Rodríguez-Palma, E. J.; Li, Y.; Wang, S.; Khanna, R.;* Dai, M.* “C–H Functionalization-Enabled 11-Step Semisynthesis of (-)-Veragranine A and Characterization of New Analogs in Osteoarthritis-related Pain Treatment” J. Am. Chem. Soc. 2024, 146, 16698-16705. Rivera, M. E.; Li, L.; Kolisetti, A. (UG); Chi, N. (UG); Dai, M.* “9-Step Synthesis of (–)-Larikaempferic Acid Methyl Ester Enabled by Skeletal Rarrangement" Chem. Commun. 2024, 60, Li, X.; Wang, D.; Yin, X.; Dai, M.; Staiger, C. J.;* Zhang, C.* “A Chemical Genetic Screen with the EXO70 Inhibitor Endosidin2 to Uncover Potential Modulators of Exocytosis in Arabidopsis” Plant Direct, 2024, 8, e592. Imaging Chen, Z.; Chen, F.; Lee, H. J.; Zhang, M.; Yin, X.; Dai, M.; Cheng, J.-X.* “LIPA-Driven Hydrolysis of Cholesteryl Arachidonate Promotes Cancer Metastasis via NF-κB” bioRxiv (DOI: https://doi.org/10.1101/2022.03.11.484042). Product Drug Discovery Liang, W.; Krabill, A. D.; Gallagher, K. S.; Muli, C.; Qu, Z.; Trader, D.; Zhang, Z.-Y.;* Dai, M.* “Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase” Tetrahedron, 2024, 156, 133918. Fang, W.; Luo, Z.-W.; Wang, Y.-C.; Zhou, W.; Li, L.; Chen, Y.; Zhang, X.; Dai, M.;* Dai, J.-J.* “An SN2 reaction at amide nitrogen enables hydrazide synthesis”. Angew. Chem. Int. Ed. 2024, 63, e202317570. Jin, Y.; Hok, S.; Bacsa, J.; Dai, M.* “Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C-H Functionalizations” J. Am. Chem. Soc. 2024, 146, asap article. Jiang, B.; Dai, M.* "Concise Total Syntheses of the 6-7-5 Hamigeran Natural Products". J. Am. Chem. Soc. 2023, 145, doi: 10.1021/jacs.3c06031. Cui, C.; Dai, M.* "Total Synthesis of UCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction". Chin. J. Chem. 2023, doi: 10.1002/cjoc.202300331. Martin, B. S.†; Ma, D.†; Saito, T.; Gallagher, K. S.; Dai, M.* "Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing". Synthesis, 2023, accepted (DOI: 10.1055/a-2107-5159). Cai, X.;† Li, L.;† Wang, Y.-C.; Zhou, J.; Dai, M.* "Total Syntheses of Phleghenrines A and C". Org. Lett. 2023, 25, 5258-5261. Dai, J.-J;† Yin, X.;† Li, L.;† Rivera, M. E.; Wang, Y.-C.;* Dai, M.* " Modular and practical diamination of Allenes". Nature Communications, 2023, 14, 1774. Sims, H. S.; Dai, M.* "Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments". J. Org. Chem. 2023, DOI: https://doi.org/10.1021/acs.joc.2c02746. Sims, H. S.*; Dai, M.* "Taming PRMT5-adaptor protein interactions" Trends Pharmacol. Sci. 2023, DOI: https://doi.org/10.1016/j.tips.2023.01.002. Li, L.; Liang, W.; Rivera, M. E.; Wang, Y.-C.; Dai, M. "Concise Synthesis of (-)-GA18 Methyl Ester" J. Am. Chem. Soc. 2023, 145, 53-57. Xu, B.;† Liu, C.;† Dai, M.;* “Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A” J. Am. Chem. Soc. 2022, 144, 19700-19703. (†contributed equally) Asberry, A. M.†; Cai, X.†; Deng, X.†; Santiago, U.†; Liu, S.; Sims, H. S.; Liang, W.; Xu, X.; Wan, J.; Jiang, W.; Camacho, C.;* Dai, M.;* Hu, C.-D.* “Discovery and biological characterization of PRMT5:MEP50 protein-protein interaction inhibitors” J. Med. Chem. 2022, 65, 13793-13812. (†contributed equally) Clark, M. G.; Gonzalez, G.; Luo, Y.; Aldana-Mendoza, J.; Carlsen, M. S.; Eakins, G.; Dai, M. Zhang, C.* "Real-Time Precision Opto-Control of Chemical Processes in Live Cells" Nature Communications, 2022, 13, 4343. de Andrade Horn, P.; Sims, H. S. Dai, M.* "Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes" J. Org. Chem. 2022, 87, 8796-8801. Peery, R.; Cui, Q.; Kyei-Baffour, K.; Josephraj, S.; Huang, C.; Dong, Z.; Dai, M.;* Zhang, J.-T.* Liu, J.-Y.;* “A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells” Bioorg. Med. Chem. 2022, 65, 116761. Luo, Y.; Li, L.; Dai, M.* “Complex Natural Products Total Syntheses Facilitated by Palladium-Catalyzed Carbonylative Cyclizations” in “The Chemical Transformations of C1 Compounds”, Volume 2, Chapter 18, 793-826, Book Editors: Kuling Ding, Xiao-Feng Wu, Buxing Han, Zhongmin Liu, Wiley. Sims, H. S.; de Andrade Horn, P.; Isshiki, R.; Lim, M. (UG); Xu, Y.; Grubbs, R. H.; Dai, M* "Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester" Angew. Chem. Int. Ed., 2022, 61, e202115633. Jiang, B.; Dai, M.* “11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C-H Functionalizations" J. Am. Chem. Soc. 2021, 143, 20084-20089. Ma, D.†; Martin, B. S.†; Gallagher S. K. (UG); Saito, T. (UG); Dai, M.* “One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine” J. Am. Chem. Soc. 2021, 143, 16383-16387. (†contributed equally) Wang, Y.-C.†; Cui, C.†; Dai, M.* "Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A" Angew. Chem. Int. Ed. 2021, 60, 24828-24832. (†contributed equally) Negi, V.; Yang, J.; Speyer, G.; Pulgarin, A.; Handen, A.; Zhao, J.; Tai, Y. Y.; Tang, Y.; Culley, M. K.; Yu, Q.; Forsythe, P.; Gorelova, A.; Watson, A. M.; Aaraj, Y. A.; Satoh, T.; Sharifi-Sanjani, M.; Rajaratnam, A.; Sembrat, J.; Provencher, S.; Yin, X.; Vargas, S. O.; Rojas, M.; Bonnet, S.; Torrino, S.; Wagner, B. K.; Schreiber, S. L.; Dai, M.; Bertero, T.; Ghouleh, I. A.; Kim, S.; Chan, S. Y.* “Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension” Science Advances, 2021, 7:eabh3794. Pal, R.; Dai, M.; Seleem, M. N.* “High-throughput screening identifies a novel natural product-inspired molecule inhibiting Clostridioides difficile in vitro and in vivo” Sci. Rep. 2021, 11, 10913. Cui, C.†; Dwyer, B. G.†; Liu, C.; Abegg, D.; Cai, Z.; Hoch, D.; Yin, X.; Qiu, N.; Liu, J.; Adibekian, A.;* Dai, M.* "Total Synthesis and Target Identification of the Curcusone Diterpenes " J. Am. Chem. Soc. 2021, 143, 4379-4386. (†contributed equally.) Raffa, N.; Won, T. H.; Sukowaty A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.; Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* "Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity" Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118. Liang, W.; Cai, X.; Dai, M.* "Cu-Catalyzed Hydroxycyclopropanol Ring-Opening Cyclization to Tetrahydrofurans and Tetrahydropyrans: Short Total Syntheses of Hyperiones" Chem. Sci. 2021, 12, 1311. Cai, X.; Liang, W.; Liu, M. (UG); Li, X. (UG); Dai, M.* "Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones" J. Am. Chem. Soc. 2020, 142, 13677-13682. Kyei-Baffour, K.; Davis, D. C.; Boskovic, Z.; Kato, N.;* Dai, M.* "Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug resistant parasites" Bioorg. Med. Chem. 2020, 28, article 115678. Total Synthesis Yin, X.; Ma, K.; Dong, Y. (UG); Dai, M.* "Pyrrole Strategy to the γ-Lactam-Containing Stemona Alkaloids: (±)-Stemoamide, (±)-Tuberostemoamide, and (±)-Sessilifoliamide A" Org. Lett. 2020, 22, 5001-5004. Peery, R.; Kyei-Baffour, K.; Dong, Z.; de Andrade Horn, P.; Dai, M.;* Liu, J.;* Zhang, J.* “Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation” J. Med. Chem. 2020, 63, 7243-7251. Total Synthesis Jiang, B.; Dai, M.* “Synthetic Studies towards the Hamigerans with a 6-7-5 Tricyclic Core” Org. Lett. 2020, 22, 4176-4179. ChemBio Huang, L.; Li, X.; Zhang, W.; Ung, N.; Liu, N.; Yin, X.; Li, Y.; Mcewan, R. E.; Dilkes, B.; Dai, M.; Hicks, G. R.; Raikhel, N. V.; Staiger, C. J. Zhang, C.* “Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibitor Cellulose Biosynthesis” Plant Cell, 2020, 32, 2141-2157.