Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R., (2016), Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894, Netherlands, DOI: 10.3233/JAD-150948. Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-? accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, DOI: 10.1016/j.neubiorev.2016.01.004. Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R., (2016), The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068, Westchester, USA, DOI: 10.5665/sleep.5756. Gardener, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Martins, R., (2016), Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672, Netherlands, DOI: 10.3233/JAD-151084. Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R., (2016), Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. British Journal of Nutrition, 115(2), 2106-2113, DOI: 10.1017/S0007114516001203. Muenchhoff, J., Poljak, A., Thalamuthu, A., Gupta, V., Chatterjee, P., Raffery, M., Masters, C., Morris, J., Bateman, J., Fagan, A., Martins, R., Sachdev, P., (2016), Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease. Science Reports, 6(2016), Article no. 29078, DOI: 10.1038/srep29078. Burnham, S., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R., Masters, C., Rowe, C., Villemagne, V., (2016), Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurology, Article in press(Article in press), Article in press, London, UK, DOI: 10.1016/S1474-4422(16)30125-9. Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R., (2016), Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26, DOI: 10.1016/j.dadm.2015.12.001. O'Bryant, S., Lista, S., Rissman, R., Edwards, M., Zhang, F., Hall, J., Zetterberg, H., Lovestone, S., Gupta, V., Graff-Radford, N., Martins, R., Jeromin, A., Waring, S., Oh, E., Kling, M., Baker, L., Hampel, H., (2016), Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 27-34, DOI: 10.1016/j.dadm.2015.12.003. Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G., (2016), The Effects of Latrepirdine on Amyloid-? Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905, Netherlands, DOI: 10.3233/JAD-150790. Gupta, V., Gupta, V., Chitranshi, N., Gangoda, S., Vander Wall, R., Abbasi, M., Golzan, M., Dheer, Y., Shah, T., Avolio, A., Chung, R., Martins, R., Graham, S., (2016), One protein, multiple pathologies: multifaceted involvement of amyloid ? in neurodegenerative disorders of the brain and retina. Cellular and Molecular Life Sciences, Article in press(Article in press), 19p., DOI: 10.1007/s00018-016-2295-x. Lim, Y., Laws, S., Villemagne, V., Pietrzak, R., Porter, T., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Martins, R., Salvado, O., Bourgeat, P., Rowe, C., Masters, C., Maruff, P., (2016), A?-related memory decline in APOE ?4 non-carriers: Implications for Alzheimer?s disease. Neurology, 86(17), 1635-1642, DOI: 10.1212/WNL.0000000000002604. Laske, C., Sohrabi, H., Jasielec, MS., Muller, S., Koehler, N., Graber, S., Forster, S., Drzezga, A., Mueller-Sarnowski, F., Danek, A., Jucker, M., Bateman, R., Buckles, V., Saykin, A., Martins, R., Morris, J., (2015), Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer?s Disease: Results of the DIAN Study. BioMed Research International, 2015(2015), Article no. 828120, New York, USA, DOI: 10.1155/2015/828120. Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA., (2015), Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48, DOI: 10.1016/j.nbd.2015.06.016. Burnham, SC., Raghavan, N., Wilson, W., Baker, D., Ropacki, MT., Novak, G., Ames, D., Ellis, K., Martins, R., Maruff, P., Masters, CL., Romano, G., Rowe, CC., Savage, G., Macaulay, SL., Narayan, V., (2015), Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer's Disease Trials: An AIBL Study. Journal of Alzheimer's Disease, 46(4), 1079-1089, Netherlands, DOI: 10.3233/JAD-143015. Leifert, WR., Nguyen, T., Rembach, A., Martins, R., Rainey-Smith, S., Masters, CL., Ames, D., Rowe, CC., Macaulay, SL., Francois, M., Fenech, MF., (2015), Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk. Journal of Alzheimer's Disease, 48(2), 443-452, Netherlands, DOI: 10.3233/JAD-150330. Pietrzak, RH., Lim, YY., Ames, D., Harrington, K., Restrepo, C., Martins, R., Rembach, A., Laws, S., Masters, CL., Villemagne, VL., Rowe, CC., Maruff, P., (2015), Trajectories of memory decline in preclinical Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Neurobiology of Aging, 36(3), 1231-1238, United States, DOI: 10.1016/j.neurobiolaging.2014.12.015. Buckley, R., Saling, M., Ellis, K., Rowe, C., Maruff, P., Macaulay, LS., Martins, R., Masters, C., Savage, G., Rainey-Smith, S., Rembach, A., Ames, D., (2015), Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment. Age and Ageing, 44(6), 1012-1019, DOI: 10.1093/ageing/afv136. Narlawar, R., Werry, EL., Scarf, AM., Hanani, R., Chua, SW., King, VA., Barron, ML., Martins, R., Ittner, LM., Rendina, LM., Kassiou, M., (2015), First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO). Journal of Medicinal Chemistry, 58(21), 8743-8749, DOI: 10.1021/acs.jmedchem.5b01288. Albrecht, MA., Szoeke, C., Maruff, P., Savage, G., Lautenschlager, NT., Ellis, KA., Taddei, K., Martins, R., Masters, CL., Ames, D., Foster, JK., (2015), Longitudinal cognitive decline in the AIBL cohort: The role of APOE e4 status. Neuropsychologia, 75(2015), 411-419, DOI: 10.1016/j.neuropsychologia.2015.06.008.