Chemical Biology Drug discovery and synthesis Antimicrobial drugs Silicon based protease inhibitors Use of heavy labels in drugs

Sellars, Jonathan D., Skipsey, Mark, Shaheed, Sadr-ul, Gravell, Sebastian, Abumansour, Hamza, Kashtl, Ghasaq, Irfan, Jawaria, Khot, Mohamed, Pors, Klaus, Patterson, Laurence H. & Sutton, Chris W. (2016). Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450. ChemMedChem 11(11): 1122-1128. Czyzewski, M., Sellars, J.D., Guliashvili, T., Tibbelin, J., Johnstone, L., Bower, J., Matthew, B., Davies, R.M.D., Henrik Ottosson, H. & Steel, P.G. (2014). The First Intramolecular Silene Diels-Alder Reactions. Chemical Communications 50(22): 2919 - 2921. Straker, Hannah E., Coxon, Christopher R., Sabbadin, Federico, Wortley, David, Hughes, David, Pohl, Ehmke, Cummins, Ian, Sellars, Jonathan D., Steel, Patrick G. & Edwards, Robert (2013). Chemical tools for investigating multiple herbicide resistance (MHR) in black grass (Alopecurus myosuroides). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245. Coxon, C.R, Straker, H.E, Wortley, D.J, Sabbadin, F, Sellars, J.D, Cummins, I, Hughes, D, Steel, P.G & Edwards, Robert (2012). Chemical tools for investigation of multiple herbicide resistance (MHR) in black grass (Alopecurus myosuroides). Abstract of the Papers of the American Chemical Society 244. Kenwright, Alan M. & Sellars, Jonathan D. (2012). Preparation and complete 1 H and 13C assignment of some pentacyclo [5.4.0.02,6.03,10.05,9]undecane-8,11-dione (PCUD) derivatives. Magnetic Resonance in Chemistry 50(12): 803-808. Dixon, D.P, Sellars, J.D, Kenwright, A.M & Steel, P.G. (2012). The maize benzoxazinone DIMBOA reacts with glutathione and other thiols to form spirocyclic adducts. Phytochemistry 77: 171-178. Dixon, D. P. , Sellars, J. D. & Edwards, R. (2011). The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands. Biochemical Journal 438(1): 63-70. Sellars, J.D & Steel, P.G (2011). Transition metal-catalysed cross-coupling reactions of P-activated enols. Chemical Society Reviews 40(10): 5170-5180. Sellars, J. D., Landrum, M., Congreve, A., Dixon, D. P., Mosely, J. A. , Beeby, A. , Edwards, R. & Steel, P. G. (2010). Fluorescence quenched quinone methide based activity probes - a cautionary tale. Organic and Biomolecular Chemistry 8: 1610-1618. Sellars, J.D & Steel, P.G (2009). Application of silacyclic allylsilanes to the synthesis of beta-hydroxy-delta-lactones: synthesis of Prelactone B. Tetrahedron 65(28): 5588-5595. Sellars, J.D & Steel, P.G (2007). Advances in the synthesis of aryltetralin lignan Lactones. European Journal of Organic Chemistry (23): 3815-3828. N.J. Hughes, R.D.C. Pullin, M.J. Sanganee, J.D. Sellars, P.G. Steel & M.J. Turner (2007). Hosomi-Sakurai Reactions of Silacyclohexenes. Organic & Biomolecular Chemistry 5(17): 2841-2848. Pullin, R.D.C, Sellars, J.D & Steel, P.G (2007). Silenes in organic synthesis: a concise synthesis of (+/-)-epi-picropodophyllin. Organic & Biomolecular Chemistry 5(19): 3201-3206. J. D. Sellars, P. G. Steel & M. J. Turner (2006). Hosomi-Sakurai reactions of silacyclic allyl silanes. Chemical Communications 22: 2385-2387. Sellars, J.D & Steel, P.G (2006). Silenes in organic synthesis: a short synthesis of prelactone B. Organic & Biomolecular Chemistry 4(17): 3223-3224.