Education: PhD - University of California, Berkeley MS - University of California, Berkeley A.B. - Chemistry and Physics, summa cum laude - Harvard University

Physical/Biomolecular Structure and Function

Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

K. Claytor, T. Theis, Y. Feng, J. Yu, D. Gooden, and W. S. Warren, ??Accessing long-lived disconnected spin-? eigenstates through spins > ???, J. Am. Chem. Soc. (Accepted), doi: 10.1021/ja505792j | J.W. Wilson, S. Degan, C.S. Gainey, T. Mitropoulos, M.J. Simpson, J.Y. Zhang, and W.S. Warren, "mparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions", J. Biomed. Opt., 20, 051012, doi: 10.1117/1.JBO.20.5.051012 | PMID: 25415567 F.E. Robles, M.C. Fischer, and W.S. Warren, "Femtosecond pulse shaping enables detection of optical Kerr-effect (OKE) dynamics for molecular imaging", Optics Letters, 39, 4788-4791, doi: 10.1364/OL.39.004788 | PMID: 25121875 R.M. Davis and W.S. Warren, "Intermolecular zero quantum coherences enable accurate temperature imaging in red bone marrow", Magn Reson Med, doi: 10.1002/mrm.25372 | PMID: 25043195 T. Theis, M. Truong, A. Coffey, E. Chekmenev, and W. S. Warren, ??LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization??, J. Magn. Reson., 248, 23-26 doi: 10.1016/j.jmr.2014.09.005 | PMID: 25299767 Y. Feng, T. Theis, T. Wu, K. Claytor, and W. S. Warren, ??Long Lived Polarization Protected by Symmetry: LOLIPOPS??, J. Chem. Phys, 141, 134307 doi: 10.1063/1.4896895 | PMID: 25296806 T. Theis, Y. Feng, T. Wu, and W.S. Warren, ??Composite and shaped pulses for efficient and robust pumping of disconnected eigenstates in magnetic resonance??, J. Chem. Phys., 140, 014201 doi: 10.1063/1.4851337 | PMID: 24410222 T.E. Villafana, W.P. Brown, J.K. Delaney, M. Palmer, W.S. Warren, and M.C. Fischer, "econd pump-probe microscopy generates virtual cross-sections in historic artwork", PNAS, 111, 1708-13 doi: 10.1073/pnas.1317230111 | PMID: 2449855 M.J. Simpson, J.W. Wilson, F. Robles, C. Dall, K. Glass, J. Simon, and W.S. Warren, "Near-infrared excited state dynamics of melanins: the effects of iron content, photo-damage, chemical oxidation, and aggregate size", J Phys Chem A, 118, 993-1003 doi: 10.1021/jp4107475 | PMID: 24446774 K.E. Claytor, T. Theis, Y. Feng, and W.S. Warren, "Measuring Long-Lived 13C-Singlet State Lifetimes at Natural Abundance", J Magn Reson, 239, 81-86 doi: 10.1016/j.jmr.2013.12.009 | PMID: 24457544 F.E. Robles, J.W. Wilson, and W.S. Warren, "Quantifying melanin spatial distribution using pump-probe microscopy and a two-dimensional morphological autocorrelation transformation for melanoma diagnosis", J Biomed Opt, 18, 120502 doi: 10.1117/1.JBO.18.12.120502 | PMID: 24296994 J.W. Wilson, L. Vajzovic, F.E. Robles, T.J. Cummings, P. Mruthyunjaya, and W.S. Warren, "Imaging microscopic pigment chemistry in conjunctival lesions using pump-probe laser microscopy", Invest Ophthalmol Vis Sci, 54, 6867-76 doi: 10.1167/iovs.13-12432 | PMID: 24065811 R.T. Branca, L. Zhang, W.S. Warren, E. Auerbach, A. Khanna, S. Degan, K. Ugurbil, and R. Maronpot, ??In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI??, PLoS ONE, 8, e74206 doi: 10.1371/journal.pone.0074206 | PMID: 24040203 F.E. Robles, P. Samineni, J.W. Wilson, and W.S. Warren, "mp-probe nonlinear phase dispersion spectroscopy", Optics Express, 21, 9353-9364 doi: 10.1364/OE.21.009353 | PMID: 23609646 Y. Feng, T. Theis, X. Liang, Q. Wang, P. Zhou, and W.S. Warren, "Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging", Journal of the American Chemical Society, 135, 9632-9635 doi: 10.1021/ja404936p | PMID: 23781874 M.J. Simpson, K.E. Glass, J.W. Wilson, P.R. Wilby, J.D. Simon, and W.S. Warren, "Pump?Cprobe microscopic imaging of Jurassic-aged eumelanin" J. Phys. Chem. Lett., 4, 1924?C1927 doi: 10.1021/jz4008036 | PMID: 23847720

M.J. Simpson, J.W. Wilson, M.T. Phipps, F.E. Robles, M.A. Selim, and W.S. Warren, "onlinear microscopy of eumelanin and pheomelanin with sub-cellular resolution", J Invest Dermatol, 133, 1822-1826 doi: 10.1038/jid.2013.37 | PMID: 23353985ffor enhance