Education: PhD - University of Toronto MS - University of Toronto BS - University of Guelph, Ontario, Canada

Synthesis/Physical/Organic

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Wilfong, E. M.; Locklear, U.; Toone, E. J. Bioorg Med Chem Lett 2010, 20, 280. Shestopalov, A. A.; Clark, R. L.; Toone, E. J. Nano Lett 2010, 10, 43. Shestopalov, A. A.; Clark, R. L.; Toone, E. J. Langmuir 2010, 26, 1449. Gao, W. P.; Liu, W. G.; Mackay, J. A.; Zalutsky, M. R.; Toone, E. J.; Chilkoti, A. Proceedings of the National Academy of Sciences of the United States of America 2009, 106, 15231. Chakrapani, H.; Bartberger, M. D.; Toone, E. J. Journal of Organic Chemistry 2009, 74, 1450. Arnold, J. J.; Choksi, Y.; Chen, X.; Shimazaki, A.; Hatten, J.; Toone, E. J.; Epstein, D. L.; Challa, P. Journal of Ocular Pharmacology and Therapeutics 2009, 25, 179. Wilfong, E. M.; Du, Y.; Schmitt, A.; Toone, E. J. Abstracts of Papers of the American Chemical Society 2008, 236. Walters, M. J.; Srikannathasan, V.; McEwan, A. R.; Naismith, J. H.; Fierke, C. A.; Toone, E. J. Bioorganic & Medicinal Chemistry 2008, 16, 710. Walters, M. J.; Toone, E. J. Nature Protocols 2007, 2, 1825. Snyder, P. W.; Lee, G.; Marszalek, P. E.; Clark, R. L.; Toone, E. J. Proceedings of the National Academy of Sciences of the United States of America 2007, 104, 2579. Snyder, P. W.; Johannes, M. S.; Vogen, B. N.; Clark, R. L.; Toone, E. J. Journal of Organic Chemistry 2007, 72, 7459. Shestopalov, A. A.; Clark, R. L.; Toone, E. J. Journal of the American Chemical Society 2007, 129, 13818. Matsuoka, K.; Goshu, Y.; Takezawa, Y.; Mori, T.; Sakamoto, J. I.; Yamada, A.; Onaga, T.; Koyama, T.; Hatano, K.; Snyder, P. W.; Toone, E. J.; Terunuma, D. Carbohydrate Polymers 2007, 69, 326. Cheriyan, M.; Toone, E. J.; Fierke, C. A. Protein Science 2007, 16, 2368. Toone, E. J. Abstracts of Papers of the American Chemical Society 2006, 231, 24. Perry, J. L.; Goldsmith, M. R.; Williams, T. R.; Radack, K. P.; Christensen, T.; Gorham, J.; Pasquinelli, M. A.; Toone, E. J.; Beratan, D. N.; Simon, J. D. Photochemistry and Photobiology 2006, 82, 1365. Fullerton, S. W. B.; Griffiths, J. S.; Merkel, A. B.; Cheriyan, M.; Wymer, N. J.; Hutchins, M. J.; Fierke, C. A.; Toone, E. J.; Naismith, J. H. Bioorganic & Medicinal Chemistry 2006, 14, 3002. Zhao, Y. L.; McCarren, P. R.; Houk, K. N.; Choi, B. Y.; Toone, E. J. Journal of the American Chemical Society 2005, 127, 10917. Winter-Vann, A. M.; Baron, R. A.; Wong, W. H.; dela Cruz, J.; York, J. D.; Gooden, D. M.; Bergo, M. O.; Young, S. G.; Toone, E. J.; Casey, P. J. Proceedings of the National Academy of Sciences of the United States of America 2005, 102, 4336.

Mori, T.; Hatano, K.; Matsuoka, K.; Esumi, Y.; Toone, E. J.; Terunuma, D. Tetrahedron 2005, 61, 2751.