Education: PhD - University of Texas at Austin BS - Trinity University

Synthesis/Biomolecular Structure and Function/Biological/Organic

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable ??wild

Nickols, N. G.; Szablowski, J. O.; Hargrove, A. E.; Li, B. C.; Raskatov, J. A.; Dervan, P. B. "Activity of a Py-Im polyamide targeted to the estrogen response element." Molecular Cancer Therapeutics, 2013, 12, 675-684. Jevgenij A. Raskatov, Nickolas G. Nickols, Amanda E. Hargrove, Georgi Marinov, Barbara Wold and Peter B. Dervan. Gene Expression Changes in a Tumor Xenograft by a Py-Im Polyamide. Proceedings of the National Academy of Sciences. 2012, 109, 16041-16045. Hargrove, Amanda E.; Raskatov, Jevgenij A.; Meier, Jordan L.; Montgomery, David C.; Dervan, Peter B. Characterization and solubilization of pyrrole-imidazole polyamide aggregates. Journal of Medicinal Chemistry. 2012, 55, 5425-5432. Raskatov, Jevgenij A.; Hargrove, Amanda E.; So, Alex Y.; Dervan, Peter B. Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear. Journal of the American Chemical Society. 2012, 134(18), 7995-7999. Hargrove, Amanda E.; Nieto, Sonia; Zhang, Tianzhi; Sessler, Jonathan L.; Anslyn, Eric V. Artificial receptors for the recognition of phosphorylated molecules. Chemical Reviews. 2011, 111(11), 6603-6782. Hargrove, Amanda E.; Ellington, Andrew D.; Anslyn, Eric V.; Sessler, Jonathan L. Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides. Bioconjugate Chemistry. 2011, 22, 388-396. Hargrove, Amanda E.; Reyes, Ryan N.; Riddington, Ian; Anslyn, Eric V.; Sessler, Jonathan L. ??Boronic acid porphyrin receptor for ginsenoside sensing.?? Organic Letters. 2010, 12(21), 4804-4807. Hargrove, Amanda E.; Zhong, Zhenlin; Shabbir, Shagufta H.; Sessler, Jonathan L., Anslyn, Eric V. ??Algorithms for the determination of binding constants and enantiomeric excess in complex host:guest equilibria using optical measurements.?? New Journal of Chemistry. 2010, 34, 348-354

Collins, Byron E.; Sorey, Steven; Hargrove, Amanda E.; Shabbir, Shagufta H.; Lynch, Vincent M.; Anslyn, Eric V. ??Probing intramolecular B-N interactions in protic m