Application of instrumental techniques to low level detection principally concerning threats to health, eg patients, workers or the general public Neonatal patient care based on dry blood spot analysis Investigation / detection of counterfeit pharmaceutical products Security applications of selected detection systems Safety of plastic packaging in food and pharmaceutical applications Forensic investigations of historical paintings particularly post Byzantine icons Work extended to include applications to the history and conservation of works of art Dried blood spot (analysis) LC-HRMS Therapeutic drug monitoring Food additive exposure assessment Medicine adherence assessment Contaminant migration into food Paediatric biomarkers Paediatric pharmacokinetics Counterfeit products medicines, drugs and food