The Fawcett Lab is interested in developmental neurobiology with an emphasis on intracellular signaling complexes underlying neuronal polarity. We utilize molecular and cellular approaches, combined with mass spectrometry based screens to characterize protein complexes involved in establishing neuronal polarity and synapse development.

Richier, L., Williton, K., Clattenburg, L., Colwill, K., O'Brien, M., Tsang, C., Kolar, A., Zinck, N., Metalnikov, P., Trimble, W.S., Krueger, S., Pawson, T.*, Fawcett, J.P.,* (2010) NOS1AP associates with Scribble and regulates dendritic spine development. J. Neurosci. 30:4796-4805. Fawcett, J.P., Georgiou, J., Ruston, J., Bladt, F., Sherman, A., Warner, N., Saab, B.J., Scott, R., Roder, J.C. Pawson, T. (2007) "Nck adaptor proteins control the organization of neuronal circuits important for walking". PNAS 104:20973-20978. Wells C*, Fawcett, J.P.*, Traweger A., Yamanaka, Y., Goudreault, M., Elder, K., Kulkarni, S., Gish, G., Virag, C., Lim C., Colwill C., Starostine, A., Metalnikov, P., Pawson, T. (2006) "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells". Cell 125:535-548.