My research is in the area of biological mass spectrometry, with emphasis on the development of innovative technologies for improved characterization of complex protein mixtures. Our technologies lead to improved understanding of disease and enable the drug discovery process.

“Implications of partial tryptic digestion in organic-aqueous solvent systems for bottom-up proteome analysis.” M. J. Wall, G. H. Carey, G. A. Simms, F. Liu, and Alan. A. Doucette* (Anal. Chim. Acta., 2011. 703, 194-203). “Top-Down and Bottom-Up Proteomics of SDS-Containing Solutions Following Mass-Based Separation.” D. Botelho, M. J. Wall, D. B. Vieira, S. Fitzsimmons, F. Liu, and Alan. A. Doucette* (J. Proteome Res., 2010, 9, 2863–2870). “Multiplexed size separation of intact proteins in solution phase for mass spectrometry.” J. C. Tran and Alan. A. Doucette* (Anal. Chem., 2009, 81, 6201 – 6209). “Rapid & effective focusing in a carrier ampholyte solution isoelectric focusing system: A proteome prefractionation tool.” J. C. Tran and Alan. A. Doucette* (J. Proteome Res., 2008, 7, 1761-1766). “Gel-eluted liquid fraction entrapment electrophoresis: An electrophoretic method for broad molecular weight range proteome separation.” J. C. Tran and Alan. A. Doucette* (Anal. Chem., 2008, 80, 1568-1573).