Dr. Darvesh is a behavioural neurologist and trained organic chemist with interest in medicinal chemistry. His research has been instrumental in determining the importance and expression of butyrylcholinesterase in the human brain. His research focus is the development of therapeutic and diagnostic agents for Alzheimer’s disease, with butyrylcholinesterase as the target.

Macdonald IR, Maxwell SP, Reid GA, Cash MK, DeBay DR, Darvesh S. 2017. Quantification of butyrylcholinesterase activity as a sensitive and specific biomarker of Alzheimer's disease. Journal of Alzheimer`s Disease. 58(2):491-505. PMID: 28453492 DeBay DR, Reid GA, Pottie I, Martin E, Bowen CV, Darvesh S. 2017. Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 3(2): 166-176. DOI: http://dx.doi.org/10.1016/j.trci.2017.01.005 Darvesh S. 2016. Butyrylcholinesterase as a diagnostic and therapeutic target for Alzheimer’s disease. Current Alzheimer Research. 13(10): 1173-1177. PMID: 27040140 Macdonald IR, Reid GA, Pottie IR, Martin E, Darvesh S. 2016. Synthesis and preliminary evaluation of phenyl 4-123I-iodophenylcarbamate for visualization of cholinesterases associated with alzheimer's disease pathology. Journal of Nuclear Medicine. 57: 297-302. PMID: 26541777 Darvesh S, Hopkins DA, Geula C. 2003. Neurobiology of butyrylcholinesterase. Nature Reviews Neuroscience. 4(2): 131-138. PMID: 12563284