The Senescence, Aging, Infection and Immunity (SAIL) laboratory studies immune responses in chronic and persistent viral infections (HIV, CMV, HCV); the role of chronic viral infection in chronologic and immunologic aging; interactions between innate and adaptive immunity in chronic viral infection and the modulation of the immune response to generate therapeutic and prophylactic vaccines in persistent viral infections. Clinically Dr. Barrett is also interested in treating viral infections in underserved and incarcerated populations.

Barrett L, SN Stapleton, ME Gallant, NJ Fudge and MD Grant. 2014. Immune resilence in human immunodeficiency virus-infected individuals seronegative for cytomegalovirus. AIDS 28(14): 2045. Zipperlen K, M Gallant, S Stapleton, L Barrett, and M Grant. 2014. Protective genotypes in HIV infection reflect superior function of KIR3DS1+ over KIR3DL1+ CD8+ T cells. Immunology and Cell Biology doi: 10.1038/icb.2014.68 Barrett L, N Trehanpati, S Poonia, L Daigh, SK Sarin, H Masur, S Kottilil. 2014. Hepatic compartmentalization of exhausted regulatory cells in HIV/HCV coinfected patients. Journal of Viral Hepatitis doi: 10.1111/jvh.12 Barrett L, M Gallant, C Howley, MI Bowmer, G Hirsch, K Peltekian, M Grant. 2011. Stronger hepatitis C virus-specific CD8+ T cell responses in HIV coinfection. Journal of Viral Hepatitis 18(3):170-180.