Titorenko, Vladimir 照片

Titorenko, Vladimir

Professor

所属大学: Concordia University

所属学院: Department of Biology

邮箱:
vladimir.titorenko@concordia.ca

个人主页:
https://www.concordia.ca/artsci/biology/faculty.html.html?fpid=vladimir-titorenko

研究领域

Molecular and cellular mechanisms of aging and age-related disorders

近期论文

Gafar, A.A., Draz, H.M., Goldberg, A.A., Bashandy, M.A., Bakry, S.,Khalifa, M.A., AbuShair, W., Titorenko,V.I. and Sanderson, J.T. Lithocholic acid induces endoplasmic reticulumstress, autophagy and mitochondrial dysfunction in human prostate cancer cells.PeerJ (2016) 4:e2445. Kyryakov, P., Gomez-Perez, A., Glebov, A., Asbah, N., Bruno, L.,Meunier, C., Iouk, T. and Titorenko,V.I. Empirical verification of evolutionary theories of aging. Aging (2016) 8:2568-2589. Arlia-Ciommo, A., Dakik, P., Leonov, A.,McAuley, M., Medkour, Y., Mohammad, K., Iouk, T., Simard, É. and Titorenko, V.I. Mechanisms throughwhich chemical compounds produced by mammals or plants delay chronologicalaging in yeast. Austin Biol. (2016)1:1011. Dakik, P. and Titorenko, V.I. Communications between mitochondria, the nucleus,vacuoles, peroxisomes, the endoplasmic reticulum, the plasma membrane, lipiddroplets and the cytosol during yeast chronological aging. Front. Genet. (2016) 7:177. Lutchman,V., Dakik, P., McAuley, M., Cortes, B., Ferraye, G., Gontmacher, L., Graziano,D., Moukhariq, F., Simard, É. and Titorenko,V.I. Six plant extracts delay yeast chronological aging through differentsignaling pathways. Oncotarget (2016)7:50845-50863. Medkour,Y., Svistkova, V. and Titorenko, V.I. Cell-nonautonomousmechanisms underlying cellular and organismal aging. Int. Rev. Cell Mol. Biol. (2016) 321:259-297. Arlia-Ciommo,A., Svistkova, V., Mohtashami, S. and Titorenko,V.I. A novel approach to the discovery of anti-tumor pharmaceuticals:searching for activators of liponecrosis. Oncotarget(2016) 7:5204-5225. Klionsky,D.J. et al. (including Titorenko, V.I.).Guidelines for the use and interpretation of assays for monitoring autophagy (3rdedition). Autophagy (2016) 12:1-222. Medkour,Y. and Titorenko, V.I. Mitochondriaoperate as signaling platforms in yeast aging. Aging (2016) 8:212-213. Lutchman,V., Medkour, Y., Samson, E., Arlia-Ciommo, A., Dakik, P., Cortes, B., Feldman,R., Mohtashami, S., McAuley, M., Chancharoen, M., Rukundo, B., Simard, E. and Titorenko, V.I. Discovery of plantextracts that greatly delay yeast chronological aging and have differenteffects on longevity-defining cellular processes. Oncotarget (2016) 7:16542-16566. Tremblay,M., Zhang, I., Bisht, K., Savage, J., Lecours, C., Parent, M., Titorenko, V.I. and Maysinger, D.Remodeling of lipid bodies by docosahexaenoic acid in activated microglialcells. J. Neuroinflammation (2016)13:116. Piano,A. and Titorenko, V.I. The intricateinterplay between mechanisms underlying aging and cancer. Aging and Disease (2015) 6:56-75. Beach,A., Leonov, A., Arlia-Ciommo, A., Svistkova, V., Lutchman, V. and Titorenko, V.I. Mechanisms by which different functional states of mitochondria define yeast longevity. Int. J. Mol. Sci. (2015) 16:5528-5554. Titorenko, V.I. andRachubinski, R.A. (editors). Origin and spatiotemporal dynamics of theperoxisomal endomembrane system. Frontiers Research Topic E-book. FrontiersMedia SA, Switzerland (2015). Leonov,A., Arlia-Ciommo, A., Piano, A., Svistkova, V., Lutchman, V., Medkour, Y. and Titorenko, V.I.Longevity extension by phytochemicals. Molecules(2015) 20:6544-6572. Beach,A., Richard, V.R., Bourque, S., Boukh-Viner, T., Kyryakov, P., Gomez-Perez,A., Arlia- Ciommo, A., Feldman, R.,Leonov, A., Piano, A., Svistkova, V. and Titorenko,V.I. Lithocholic bile acid accumulated in yeast mitochondria orchestrates adevelopment of an anti-aging cellularpattern by causing age-related changes in cellular proteome. Cell Cycle (2015) 14:1643-1656. Shebani,S., Jones, N., Eid, R., Gharib, N., Arab, N., Titorenko, V.I., Vali, H., Young, P. and Greenwood, M. Inhibitionof stress mediated cell death by human Lactate Dehydrogenase B (LDHB) in yeast.FEMS Yeast Res. (2015) 15:fov032. Sheibani,S., Richard, V.R., Beach, A., Leonov, A., Feldman, R., Khelghatybana, L., Piano, A., Greenwood, M., Vali, H. and Titorenko, V.I. Macromitophagy, neutrallipids synthesis and peroxisomal fattyacid oxidation protect yeast from “liponecrosis”, a previously unknown form of programmed celldeath. Cell Cycle (2014) 13:138-147. Goldberg,A.A., Titorenko, V.I., Beach, A.,Abdelbaqi, K., Safe, S. and Sanderson, J.T. Ring- substituted analogs of 3, 3'-diindolylmethane (DIM) induceapoptosis and necrosis in androgen- dependent and -independent prostate cancercells. Invest. New Drugs (2014)32:25-36. Burstein,M.T. and Titorenko, V.I. Amitochondrially targeted compound delays aging in yeast through a mechanismlinking mitochondrial membrane lipid metabolism to mitochondrial redox biology.Redox Biol. (2014) 2:305-307. Richard,V.R., Bourque, S.D. and Titorenko, V.I.Metabolomic and lipidomic analyses of chronologically aging yeast. In: YeastGenetics. Methods and Protocols. Eds. Smith, J.S. and Burke, D.J. Humana Press,USA, pp. 359-373 (2014). Arlia-Ciommo,A., Leonov, A., Piano, A., Svistkova, V. and Titorenko, V.I. Cell- autonomous mechanisms of chronological agingin the yeast Saccharomyces cerevisiae.Microbial Cell (2014) 1:164-178. Martins,D., Titorenko, V.I. and English,A.M. Cells with impaired mitochondrial H2O2 sensinggenerate less •OH radicals and live longer. Antioxid.Redox. Signal. (2014) 21:1490-1503. Richard,V.R., Bourque, S.D. and Titorenko, V.I.Metabolomic and lipidomic analyses of chronologically aging yeast. Methods Mol. Biol. (2014) 1205:359-373. Arlia-Ciommo,A., Piano, A., Svistkova, V., Mohtashami, S. and Titorenko, V.I. Mechanisms underlying the anti-aging and anti-tumoreffects of lithocholic bile acid. Int. J. Mol. Sci. (2014) 15:16522-16543.