Ph.D., Massachutsetts Institute of Technology

Research interests currently focus on the study of significant problems in the general area of biological chemistry, particularly those concerning the biosynthesis of natural products, multiple drug-resistant bacterial infectious diseases and cancer. These studies demand the intimate interplay of synthetic organic chemistry, physical organic chemistry, microbiology, and molecular biology. The study of medically significant natural products and mechanism-based synthetic substances is a key element of the approach utilized. New synthetic organic methodology is frequently developed in our group as a result of the needs to synthesize biomechanistically intriguing natural products, analogs of natural products, and mechanistically inspired probe molecules.