PhD, University of Nevada School of Medicine PharmD, Idaho State University College of Pharmacy BS, Idaho State University

Ion channels regulate the function and activity of excitable tissues such as nerve and muscle. Research in the lab involves the study of ion channels in arterial smooth muscle and their impact on arterial function. Changes in ion channel behavior during pathophysiological conditions such as hypertension are of particular interest.

Amberg GC, Earley S, Glapa SA. 2010. Local regulation of arterial L-type calcium channels by reactive oxygen species. Circ Res 107(8):1002-1010. Crnich R, Amberg GC, Leo MD, Gonzales AL, Tamkun MM, Jaggar JH, Earley S. 2010. Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. Am J Physiol Cell Physiol 299(3):C682-694. Gonzales AL, Amberg GC, Earley S. 2010. Ca2+ release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells. Am J Physiol Cell Physiol 299(2):C279-288. Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF. 2008. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proc Natl Acad Sci USA 7;105(40):15623-8. Amberg GC, Navedo MF, Nieves-Cintrón M, Molkentin JD, Santana LF. 2007. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. J Physiol 579:187-201.