I am interested in cell signalling and metabolism during animal fertilization and early embryo development. I use live cell imaging methods including those based on fluorescence and chemiluminescence.

Bradley, J.et al. 2016. Quantitative imaging of lipids in live mouse oocytes and early embryos using CARS microscopy. Development 143, pp. 2238-2247. (10.1242/dev.129908) pdf Swann, K. and Lai, F. A. 2016. The sperm phospholipase C- and Ca2+ signalling at fertilization in mammals. Biochemical Society Transactions 44(1), pp. 267-272. (10.1042/BST20150221) Haverfield, J.et al. 2016. Ca2+ dynamics in oocytes from naturally-aged mice. Scientific Reports 6, article number: 19357. (10.1038/srep19357) pdf Swann, K. and Lai, F. A. 2016. Egg activation at fertilization by a soluble sperm protein. Physiological Reviews 96(1), pp. 127-149. (10.1152/physrev.00012.2015) Nomikos, M.et al. 2015. Essential role of the EF-hand domain in targeting sperm phospholipase Cζ to membrane phosphatidylinositol 4,5-bisphosphate (PIP2). Journal of Biological Chemistry 290(49), pp. 29519-29530. (10.1074/jbc.M115.658443) pdf Sanusi, R.et al. 2015. Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ. Molecular Human Reproduction 21(10), pp. 783-791. (10.1093/molehr/gav042) pdf Nomikos, M.et al. 2015. Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation. Molecular Human Reproduction 21(9), pp. 702-710. (10.1093/molehr/gav034) Kashir, J.et al. 2015. PLC or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. Molecular Human Reproduction 21(5), pp. 383-388. (10.1093/molehr/gav009) Nomikos, M., Swann, K. and Lai, F. A. 2015. Is PAWP the 'real' sperm factor?. Asian Journal of Andrology 17(3), pp. 444-446. (10.4103/1008-682X.142145)