Gumbleton, Mark 照片

Gumbleton, Mark

Professor

所属大学: Cardiff University

所属学院: School of Pharmacy and Pharmaceutical Sciences

邮箱:
gumbleton@cardiff.ac.uk

个人主页:
http://www.cardiff.ac.uk/people/view/90839-gumbleton-mark

个人简介

Currently Executive Editor for Advanced Drug Delivery Reviews, a journal publishing high quality thematic reviews on a wide range of Advanced Drug Delivery topics.

Also on the editorial board of the Journal of Drug Targeting and International Journal of Nanomedicine.

I have published over:

90 full-length peer reviewed research publications 20 journal series, authored textbook chapters or edited books 116 conference abstracts or editorials. I have supervised 25 successful PhD students and 24 postdoctoral/visiting scientists.

I have served on a number of pan-European scientific steering committees in drug delivery and as organiser/ scientific programme organiser for International scientific meetings. I also serve as a consultant to pharmaceutical industry in USA and UK and is Director of Research at the School of Pharmacy and Pharmaceutical Sciences, Cardiff University.

研究领域

Hypothesis-driven science surrounding issues at the interface between the nature of biological barriers and experimental therapeutics.

The laboratory maintains a wide range of techniques ranging from cell and molecular biology through to ex-vivo and in-vivo models to address the scientific issues.

There are two principle areas within the laboratory's research strategy: blood-brain-barrier and in the developing area of brain tumour research.

近期论文

Paul, G. R., Gumbleton, M. and Somers,, G. I. 2017. Effect of conditioning on rat lung function measurements and implications for exposure and dose estimation of inhaled drugs. Inhalation Campbell, L.et al. 2016. Phospho-4e-BP1 and eIF4E overexpression synergistically drives disease progression in clinically confined clear cell renal cell carcinoma. American Journal of Cancer Research 5(9), pp. 2838-2848. pdf Williams, N.et al. 2016. Evidence of nonuniformity in urothelium barrier function between the upper urinary tract and the bladder. The Journal of Urology 195(3), pp. 763-770. (10.1016/j.juro.2015.10.066) pdf Ulaeto, D.et al. 2016. Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets. Antimicrobial Agents and Chemotherapy , article number: AAC.02146-15. (10.1128/AAC.02146-15) pdf Rohrer, J.et al. 2016. Mucus permeating thiolated self-emulsifying drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics 98, pp. 90-97. (10.1016/j.ejpb.2015.11.004) pdf Aljayyoussi, G.et al. 2015. Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters. International Journal of Pharmaceutics 496(2), pp. 834-841. (10.1016/j.ijpharm.2015.10.036) pdf Albaldawi, M.et al. 2015. Nanoparticle diffusion within intestinal mucus: Three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles. European Journal of Pharmaceutics and Biopharmaceutics 97(Part A), pp. 230-238. (10.1016/j.ejpb.2015.01.023) pdf Grießinger, J.et al. 2015. Methods to determine the interactions of micro- and nanoparticles with mucus. European Journal of Pharmaceutics and Biopharmaceutics 96, pp. 464-476. (10.1016/j.ejpb.2015.01.005) pdf