My research focuses on the cellular and network mechanisms operating in the thalamus and cortex during sleep and absence epilepsy. Recently, we also developed an interest in the mechanisms involved in astrocyte-neuron signalling. My multi-disciplinary group uses a combination of electrophysiological, morphological, immunocytochemical and confocal imaging techniques both in normal and transgenic in vivo and in vitro animal models, as well as a computational approach for simulations of neuronal and astrocytic network activities.

Guo, J.et al. 2016. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 15(13), pp. 1336-1345. (10.1016/S1474-4422(16)30295-2) Venzi, M.et al. 2016. Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology 108, pp. 292-304. (10.1016/j.neuropharm.2016.04.016) pdf Connelly, W., Crunelli, V. and Errington, A. 2016. Passive synaptic normalization and input synchrony-dependent amplification of cortical feedback in thalamocortical neuron dendrites. Journal of Neuroscience 36(13), pp. 3735-3754. (10.1523/JNEUROSCI.3836-15.2016) pdf David, F.et al. 2016. Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons. Frontiers in Neural Circuits 10, pp. 1-11., article number: 10. (10.3389/fncir.2016.00010) pdf Lidster, K.et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, pp. 2-25. (10.1016/j.jneumeth.2015.09.007) pdf Avoli, M., Crunelli, V. and Jefferys, J. 2016. Preface for methods and models in epilepsy research. Journal of Neuroscience Methods 260, pp. 1. (10.1016/j.jneumeth.2015.11.016) Lidster, K.et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, pp. 2-25. (10.1016/j.jneumeth.2015.09.007) pdf Connelly, W.et al. 2016. The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. Frontiers in Neural Circuits 9, article number: 89. (10.3389/fncir.2015.00089) pdf Crunelli, V. and Di Giovanni, G. 2015. Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [Letter]. CNS Neuroscience & Therapeutics 21(12), pp. 967-970. (10.1111/cns.12480) pdf Connelly, W. M., Crunelli, V. and Errington, A. C. 2015. The global spike: conserved dendritic properties enable unique Ca2+ spike generation in low-threshold spiking neurons. Journal of Neuroscience 35(47), pp. 15505-15522. (10.1523/JNEUROSCI.2740-15.2015) pdf