Qualifications:

BA Hons Cantab, MBBS, MD (Lond), FRCP, FRCpath

My research interests focus on blood clotting. This includes studies into the diagnosis and treatment of inherited and acquired bleeding and laboratory studies into understanding of mechanisms of how blood clots.

Aldrovandi, M.et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001) pdf Heurich-Sevcenco, M.et al. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017) pdf Collins, P.et al. 2016. Patterns of bruising in preschool children with inherited bleeding disorders: a longitudinal study. Archives of Disease in Childhood (10.1136/ archdischild-2015-310196) pdf Hinz, C.et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291(26), pp. 13448-13464. (10.1074/jbc.M115.700609) pdf Obaji, S.et al. 2016. Unclassified bleeding disorders: outcome of haemostatic challenges following tranexamic acid and/or desmopressin. Haemophilia 22(2), pp. 285-291. (10.1111/hae.12811) Bruynseels, D.et al. 2015. Commentary on reconstituting fibrinogen concentrate to maintain blinding in a double-blind, randomized trial in an emergency Setting. Journal of Emergency Medicine 28(1), pp. 104-107.e.1. (10.1016/j.jemermed.2015.09.017) Agbani, E.et al. 2015. Coordinated membrane ballooning and procoagulant spreading in human platelets. Circulation 132(15), pp. 1414-1424. (10.1161/CIRCULATIONAHA.114.015036) Fletcher, S.et al. 2015. SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects. The Journal of Clinical Investigation 125(9), pp. 3600-3605. (10.1172/JCI80347)