Our work focuses on the identification of molecular pathways and neuronal networks involved in the development of social skills, and their breakdown in pathological conditions. We use a combination of genetic, behavioural, molecular and imaging methods in wild type and genetic mouse models carrying mutations associated with different pathological conditions, in particular autism or schizophrenia.

Baudouin, S. J. 2014. Heterogeneity and convergence: the synaptic pathophysiology of autism. European Journal of Neuroscience 39(7), pp. 1107-1113. (10.1111/ejn.12498) Louveau, A.et al. 2013. Impaired spatial memory in mice lacking CD3ζ is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. The Journal of Neuroscience 33(47), pp. 18672-18685. (10.1523/JNEUROSCI.3028-13.2013) pdf Baudouin, S. J. 2013. Apport des modèles murins dans l'autisme syndromique et non syndromique. médecine/sciences 29(2), pp. 121-123. (10.1051/medsci/2013292002) pdf Budreck, E.et al. 2013. Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. Proceedings of the National Academy of Sciences of the United States of America 110(2), pp. 725-730. (10.1073/pnas.1214718110) Baudouin, S.et al. 2012. Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism. Science 338(6103), pp. 128-132. (10.1126/science.1224159) Angibaud, J.et al. 2011. The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis. Journal of Neurochemistry 119(4), pp. 708-722. (10.1111/j.1471-4159.2011.07469.x) Angibaud, J.et al. 2011. Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification. Journal of Molecular Neuroscience 46(2), pp. 431-441. (10.1007/s12031-011-9607-2) Baudouin, S.et al. 2008. The signaling adaptor protein CD3ζ is a negative regulator of dendrite development in young neurons. Molecular Biology of the Cell 19(6), pp. 2444-2456. (10.1091/mbc.E07-09-0947) pdf Baudouin, S.et al. 2006. Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation. Molecular and Cellular Neuroscience 33(2), pp. 160-169. (10.1016/j.mcn.2006.07.007)