December 2003 Doctor of Philosophy, Chemistry, University of Chicago, Chicago, IL August 1998 Master of Science, Chemistry, University of Chicago, Chicago, IL May 1997 Bachelor of Arts, Chemistry and Music (cum laude), Augustana College, Sioux Falls, SD

Hamm, M.L.; Schwans, J.P.; Piccirilli, J.A. “The hammerhead ribozyme catalyzes the deglycosylation of 2’-mercaptocytidine” J. Am. Chem. Soc. (2000) 122, 4223-4224. Schwans, J.P.; Cortez, C.N.; Olvera, J.A.; Piccirilli, J.A. “2’-Mercaptonucleotide interference reveals regions of close packing within folded RNA molecules” J. Am. Chem. Soc. (2003) 125, 10012-10018. Gordon, P.M.; Fong, R.; Deb, S.K.; Li, N.S.; Schwans, J.P.; Ye, J.D.; Piccirilli, J.A. “New strategies for exploring RNA’s 2’-OH expose the importance of solvent during group II intron catalysis” Chem. Biol. (2004) 11, 237-246. Schwans, J.P.; Li, N.S.; Piccirilli, J.A. “A packing density metric for exploring the interior of folded RNA molecules” Angew. Chem. Intl. Ed. (2004) 43, 3033-3037. Das, R.; Kudaravalli, M.; Jonikas, M.; Laederach, A.; Fong, R.; Schwans, J.P.; Baker, D.; Piccirilli, J.A.; Altman, R.B.; Herschlag, D. “Structural inference of native and partially folded RNA by high-throughput contact mapping” Proc. Natl. Acad. Sci. U.S.A. (2008) 105, 4144- 4149. Schwans, J.P.*; Kraut, D.A.*; Herschlag, D. “Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A. (2009) 106, 14271-14275. Forconi, M.*; Schwans, J.P.*; Porecha, R.; Sengupta, R.; Piccirilli, J.A.; Herschlag, D. “2’-Fluoro substituents can mimic native 2’-hydroxyls within structured RNA” Chem. Biol. (2011) 18, 949-954. Schwans, J.P.; Sunden, F.; Gonzalez, A.; Tsai, Y.; Herschlag, D. “Evaluating the catalytic contribution from the oxyanion hole in ketosteroid isomerase” J. Am. Chem. Soc. (2011) 133, 20052-20055. Fafarman, A.T.*; Sigala, P.A.*; Schwans, J.P.; Fenn, T.; Herschlag, D.; Boxer, S. “Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A. (2012) 109, E299-308. Ruben, E.A.*; Schwans, J.P.*; Sonnett, M.; Natarajan, A.; Gonzalez, A.; Tsai, Y.; Herschlag, D. "Ground state destabilization from a positioned general base in the ketosteroid isomerase active site" Biochemistry (2013) 52, 1074-1081. Sigala, P.A.*; Fafarman, A.T.*; Schwans, J.P.*; Fried, S.D.; Fenn, T.D.; Caaveiro, J.M.; Pybus, B.; Ringe, D.; Petsko, G.A.; Boxer, S.G.; Herschlag, D. "Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site" Proc. Natl. Acad. Sci. U.S.A. (2013) 110, E2552-2561. Schwans, J.P.; Sunden, F.; Lassila, J.K.; Gonzalez, A.; Tsai, Y.; Herschlag, D. "Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site" Proc. Natl. Acad. Sci. U.S.A. (2013) 110, 11308-11313. Schwans, J.P.; Sunden, F.; Gonzalez, A.; Tsai, Y.; Herschlag, D. "Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase" Biochemistry (2013) 52, 7840-7855. Schwans, J.P.; Hanoian, P.; Lengerich B.J.; Sunden, F.; Gonzalez, A.; Tsai, Y.; Hammes-Schiffer, S.; Herschlag, D. "Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site" Biochemistry (2014) 53, 2541-2555. Natarajan, A.; Schwans, J.P.; Herschlag, D. "Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site. J. Am. Chem. Soc. (2014) 136, 7643-7654. Natarajan, A.; Yabikarski F.; Lamba V.; Schwans, J.P.; Sunden, F.; Herschlag, D. Biophysics. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase" Science (2015) 349, 936. Gonzalez, J.; Ramirez, J.; Schwans J.P. "Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase" Amino Acids (2016) Epub ahead of print.