Post-Doctoral Research: Emory University (Professor Dennis Liotta) Ph.D. in Medicinal Chemistry: State University of New York at Buffalo (Professor Michael Detty) B.S. in Biochemistry: State University of New York at Fredonia (Professor Michael Milligan) A.S. in Liberal Arts: State University of New York Erie Community College

My research interest is in synthetic organic medicinal chemistry, specifically the design and synthesis of small molecule α-helix mimetics for targeting the E6 oncoprotein in high risk strains of human papillomavirus (HPV). Computational docking experiments aid in our design of novel classes of α-helix mimetic drugs. We use organic synthetic chemistry to make target compounds that will be tested for their potency against HPV-16 E6 in collaboration with biochemical research groups. We can also append photosensitizing moieties to compounds showing activity in an effort to make drugs useful for photodynamic inactivation (PDI) of the virus.

Sabatini, R. P., Eckenhoff, W. T., Orchard, A., Liwosz, K. R., Detty, M. R., Watson, D. F., McCamant, D.W., & Eisenberg, R. From Seconds to Femtoseconds: Solar Hydrogen Production and Transient Absorption of Chalcogenorhodamine Dyes. Journal of the American Chemical Society, 2014, 136 (21), 7740 - 7750 Orchard, A., Schamerhorn, G. A., Calitree, B. D., Sawada, G. A., Loo, T. W., Claire Bartlett, M., Clarke, D.M., & Detty, M. R. Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1). Bioorganic & Medicinal Chemistry, 2012, 20 (14), 4290-4302. Orchard, A., Mulhern, K. R., Watson, D. F., Detty, M. R. Influence of Surface -attachment Functionality on the Aggregation, Persistence, and Electron- Transfer Reactivity of Chalcogenorhodamine Dyes on TiO2. Langmuir, 2012, 28 (17), 7071-7082. McCormick, T. M., Calitree, B. D., Orchard, A., Kraut, N. D., Bright, F. V., Detty, M. R., & Eisenberg, R. Reductive side of water splitting in artificial photosynthesis: New homogeneous photosystems of great activity and mechanistic insight. Journal of the American Chemical Society, 2010, 132(44), 15480-15483.