University of Toronto, Postdoctoral Researcher Ph.D. University of Colorado, Boulder, CO B.Sc. Georgia Southern University, Statesboro, GA

My background in organic reaction development and current work in medicinal chemistry has steered my own research interests towards the development of innovative synthetic methods and their utilization in building small molecules that inhibit protein-protein interactions of therapeutic relevance. More information can be found on my website.

“Designed Metabolic Optimization of Potent Stat3 Protein Inhibitors as Pancreatic Cancer Therapeutics”. Arpin, C. C.; Page, B. D. G.; Haftchenary, S.; Fishel, M. L.; Gunning, P. T. Journal of Medicinal Chemistry 2013, in preparation. “Application of Small Molecule Stat3 Protein-Membrane Anchors in Human Cancers”. Arpin, C. C.; Avadisian, M. A.; Yue, P.; Gunning, P. T. Chemical Communications 2013, in preparation. “Combined STAT3 and BCR-ABL1 Inhibition Restores Response in Therapy-Resistant Chronic Myeloid Leukemia”. Eiring, A. M.; Page, B. D. G.; Kraft, I. L.; Mason, C. C.; Zhang, T. Y.; Vellore, N. A.; Khorashad, J. S.; Engar, A. J.; Reynolds, K. R.; Zabriskie, M. S.; Anderson, D. J.; Senina, A.; Pomicter, A. D.; Arpin, C. C.; Ahmad, S.; Heaton, W. L.; Tantravahi, S.; Moriggl, R.; Baron, R.; O’Hare, T.; Gunning, P.T.; Deininger, M. W. Nature Chemical Biology 2013, submitted. “BP-4-018, a Novel Small-Molecule Inhibitor of STAT3, Demonstrates Significant Anti-tumor Activity Against Multiple Myeloma”. Croucher, D.C.; Page, B. D. G.; Li, Z. H.; Aman, A.; Arpin, C. C.; Gunning, P. T.; Trudel, S. Cancer Research 2013, submitted. “Progress towards the development of SH2 domain inhibitors”. Arpin, C. C.; Kraskouskya, D.; Duodu, E.; Gunning, P. T.Chemical Society Reviews 2013, 42, 3337-3370. “The Total Synthesis of Dermostatin A”. Zhang, Y.; Arpin, C. C.; Cullen, A. J.; Mitton-Fry, M. J.; Sammakia, T. Journal of Organic Chemistry 2011, 76 (19), 7641-7653. “New Inhibitors of Colony Spreading in Bacillus subtilis and Bacillus anthracis”. Hao, X.; Nguyen, T.; Kearns, D. B.; Arpin, C. C.; Fall, R.; Sammakia, T. Bioorganic and Medicinal Chemistry Letters 2011, 21 (18), 5583-5588.